Product image of Insuman Comb 30 (Insulin Human) supplied by GNH India

Insuman Comb 30

Active Ingredient:
Insulin Human
Origin:
EU

Insuman Comb 30 (Insulin Human)

Insulin human, the active ingredient in Insuman Comb 30, is a insulin presented as a premixed injectable formulation for subcutaneous use. It is used to lower blood glucose in patients with diabetes mellitus, both type 1 and type 2.
GNH India supplies Insuman Comb 30 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sanofi-Aventis Deutschland Gmbh

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Indications & Clinical Uses

Insuman Comb 30 is an insulin preparation that acts on the glucose regulation pathway in diabetes mellitus.

  • Type 1 diabetes mellitus: provides basal and prandial glucose control in insulin‑deficient patients.
  • Type 2 diabetes mellitus: improves glycaemic control when oral agents are insufficient.
  • Gestational diabetes mellitus: offers safe insulin therapy to maintain maternal and fetal glucose levels.

How It Works

  • Insulin human binds to insulin receptors on muscle, adipose and hepatic cells, activating the receptor’s tyrosine kinase activity. This triggers intracellular signaling that promotes glucose uptake, glycogen synthesis, and lipogenesis while suppressing hepatic gluconeogenesis, thereby reducing circulating blood glucose levels.

Side Effects

Common Side Effects

  • Hypoglycaemia: low blood sugar episodes, especially if meals are missed or dosing is excessive.
  • Injection site reactions: redness, swelling, or itching at the injection site.
  • Weight gain: increased caloric storage due to improved glucose utilization.
  • Edema: mild fluid retention, particularly in the lower extremities.
  • Lipodystrophy: localized changes in fat tissue with repeated injections.

Serious or Rare Side Effects

  • Severe hypoglycaemia: neuroglycopenic symptoms requiring immediate assistance.
  • Allergic reactions: urticaria, angioedema, or anaphylaxis.
  • Insulin antibodies: may alter insulin effectiveness and cause resistance.
  • Hypokalemia: low potassium levels secondary to intracellular shift.
  • Acute pancreatitis: rare inflammatory response of the pancreas.

Precautions & Warnings

Insuman Comb 30 requires careful monitoring and patient education.

  • Dose adjustment: individualize based on blood glucose monitoring and dietary intake.
  • Hypoglycaemia risk: advise patients to recognize early signs and have rapid‑acting carbohydrate available.
  • Concomitant illnesses: infections or stress may increase insulin requirements.
  • Pregnancy and lactation: use only if benefits outweigh potential risks and under medical supervision.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake the vial.

Avoid Interactions

Insuman Comb 30 may interact with several drug classes.

Major Interactions (Avoid)

  • Beta‑blockers: can mask hypoglycaemia symptoms, requiring closer glucose monitoring.
  • Sulfonylureas or meglitinides: additive risk of severe hypoglycaemia.
  • Alcohol: potentiates insulin’s glucose‑lowering effect, increasing hypoglycaemia risk.

Moderate Interactions (Monitor Closely)

  • Corticosteroids: may raise blood glucose, necessitating dose adjustments.
  • Thiazide diuretics: can impair glucose tolerance, requiring closer monitoring.
  • Thyroid hormones: alterations in metabolic rate may affect insulin needs.

Frequently Asked Questions

Insuman Comb 30 is a premixed insulin formulation containing insulin human. It is prescribed to manage blood glucose levels in patients with type 1 diabetes, type 2 diabetes, and gestational diabetes when insulin therapy is required.

Insulin human mimics the natural hormone insulin. It binds to insulin receptors on muscle, fat, and liver cells, activating pathways that increase glucose uptake, promote glycogen storage, and suppress glucose production, thereby lowering circulating blood sugar.

The dose of Insuman Comb 30 is individualized. A qualified prescriber determines the amount based on the patient’s blood glucose readings, diet, activity level, and overall treatment goals. Patients should follow the dosing instructions provided by their healthcare professional.

Insulin human is classified as a pregnancy‑category drug only when the benefits outweigh potential risks. It is generally considered safe for use in pregnancy and lactation under medical supervision, but the prescriber should evaluate each case.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Insuman Comb 30 is a premixed insulin containing a fixed ratio of rapid‑acting and intermediate‑acting insulin human. Compared with basal‑only insulins, it offers both basal and prandial coverage in a single injection, which can simplify regimens but provides less flexibility than basal‑bolus therapy.

Store Insuman Comb 30 at 2‑8 °C (refrigerated). Keep the vial in its original packaging, protect it from light, and avoid freezing. If needed, it may be kept at controlled room temperature for up to 28 days, but any unused portion should be discarded after that period.

Insuman Comb 30 is administered by subcutaneous injection, typically into the abdomen, thigh, or upper arm. The injection site should be rotated to reduce the risk of lipodystrophy. Patients must be trained on proper injection technique and needle disposal.

The most serious risks include severe hypoglycaemia, which can cause loss of consciousness or seizures, and allergic reactions ranging from rash to anaphylaxis. Patients should be educated to recognize early signs and seek immediate medical attention if serious symptoms occur.

Insuman Comb 30 should be avoided in individuals with known hypersensitivity to insulin human or any excipients in the formulation. It is also contraindicated in patients with severe hypoglycaemia unresponsive to treatment until the underlying cause is resolved.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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