Product image of Insuman Comb 30 (Insulin Human) supplied by GNH India

Insuman Comb 30

Active Ingredient:
Insulin Human
Origin:
EU

Insuman Comb 30 (Insulin Human)

Insulin human, the active ingredient in Insuman Comb 30, is an insulin presented as a premixed formulation for subcutaneous use. It treats hyperglycemia in type 1 and type 2 diabetes mellitus by providing both basal and prandial insulin coverage.

GNH India supplies Insuman Comb 30 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sanofi-Aventis Deutschland Gmbh

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Indications & Clinical Uses

Insuman Comb 30 is an insulin product used to manage blood glucose in diabetes mellitus and related insulin‑deficiency conditions.

  • Type 1 diabetes mellitus: provides basal and mealtime insulin to achieve glycemic control.
  • Type 2 diabetes mellitus: adds exogenous insulin when oral agents are insufficient.
  • Insulin‑deficiency states: replaces missing endogenous insulin to maintain normal glucose metabolism.

How It Works

  • Insulin human binds to insulin receptors on muscle, adipose and hepatic cells, activating the receptor’s intrinsic tyrosine kinase activity. This triggers intracellular signaling pathways that promote glucose uptake, glycogen synthesis and lipogenesis while inhibiting hepatic gluconeogenesis, thereby lowering circulating blood glucose levels.

Side Effects

Insuman Comb 30 may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Hypoglycemia: low blood glucose episodes, especially if meals are missed.
  • Injection‑site reactions: redness, swelling or bruising at the injection site.
  • Weight gain: increased caloric storage associated with improved glucose utilization.
  • Lipodystrophy: localized changes in subcutaneous fat.
  • Edema: mild fluid retention.
  • Nausea: occasional gastrointestinal discomfort.

Serious or Rare Side Effects

  • Severe hypoglycemia: neurological impairment requiring immediate treatment.
  • Allergic reactions: urticaria, angioedema or anaphylaxis.
  • Insulin antibodies: may alter insulin action or cause resistance.
  • Hypokalemia: low potassium levels in rare cases.
  • Lipoatrophy: loss of subcutaneous fat at injection sites.

Precautions & Warnings

When using Insuman Comb 30, clinicians and patients should observe several safety measures.

  • Dose individualization: adjust based on blood‑glucose monitoring and clinical response.
  • Hypoglycemia risk: avoid dosing when fasting or if meals are delayed.
  • Illness management: monitor more frequently during infection or stress.
  • Renal/hepatic impairment: consider reduced clearance and adjust dose accordingly.
  • Pregnancy and lactation: safety data are limited; use only if benefits outweigh risks.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Insuman Comb 30 can interact with several drug classes, influencing glucose control.

Major Interactions (Avoid)

  • Sulfonylureas: combined use markedly increases risk of severe hypoglycemia.
  • Potent β‑adrenergic blockers: may mask typical hypoglycemia symptoms such as tachycardia.

Moderate Interactions (Monitor Closely)

  • Thiazide diuretics: can raise blood glucose, requiring dose adjustment.
  • Systemic corticosteroids: may increase insulin requirements.
  • ACE inhibitors: may potentiate hypoglycemic episodes, especially in the elderly.

Frequently Asked Questions

Insuman Comb 30 is a premixed insulin formulation used to lower blood glucose in patients with type 1 or type 2 diabetes mellitus. It provides both basal and prandial insulin action, helping achieve target glycemic levels when oral therapies are insufficient.

Insulin human mimics the natural hormone insulin. It binds to insulin receptors on muscle, fat and liver cells, activating signaling pathways that increase glucose uptake, promote glycogen storage, and suppress hepatic glucose production, thereby reducing circulating blood sugar.

The dose of Insuman Comb 30 is individualized by the prescribing clinician based on the patient’s blood‑glucose readings, body weight, diet, activity level and overall treatment goals. No fixed regimen is provided; the prescriber determines the appropriate amount.

Safety data for insulin human in pregnancy and lactation are limited. It may be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and only under close medical supervision.

To request Insuman Comb 30, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where needed) and import documentation.

Insuman Comb 30 is a premixed 30% protamine‑crystallized and 70% soluble insulin human formulation, offering both basal and rapid‑acting coverage in a single injection. Compared with basal‑only insulins, it reduces injection frequency but provides less flexibility for precise basal‑prandial adjustments than separate basal and rapid‑acting products.

Store Insuman Comb 30 at 2‑8 °C (refrigerated) in its original container, protected from light. Do not freeze or shake the vial. Once in use, it may be kept at room temperature for up to 28 days, but any unused portion should be discarded after that period.

Insuman Comb 30 is administered by subcutaneous injection, typically into the abdomen, thigh or upper arm. The injection should be given at the same time each day, and the dose is adjusted according to blood‑glucose monitoring and the prescriber’s instructions.

The most serious risks include severe hypoglycemia, which can cause loss of consciousness or seizures, and allergic reactions ranging from rash to anaphylaxis. Patients should be educated to recognize early signs of hypoglycemia and seek immediate medical attention for any suspected allergic response.

Insuman Comb 30 should be avoided in individuals with a known hypersensitivity to insulin human or any excipients in the formulation. It is also contraindicated in patients experiencing hypoglycemia until the condition is corrected, and caution is advised in those with severe renal or hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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