Product image of Insuman Comb 30 (Insulin Human) supplied by GNH India

Insuman Comb 30

Active Ingredient:
Insulin Human
Origin:
EU

Insuman Comb 30 (Insulin Human)

Insulin Human, the active ingredient in Insuman Comb 30, is an insulin presented as a premixed insulin injection for subcutaneous use. It treats type 1 and type 2 diabetes mellitus in adults and children as appropriate.

GNH India supplies Insuman Comb 30 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sanofi-Aventis Deutschland Gmbh

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Indications & Clinical Uses

Insuman Comb 30 is a premixed insulin that provides basal and prandial coverage for diabetes management.

  • Type 1 diabetes mellitus: supplies combined rapid‑acting and intermediate‑acting insulin to control fasting and post‑prandial glucose.
  • Type 2 diabetes mellitus: adds insulin therapy when oral agents no longer achieve target glycaemia.
  • Diabetes mellitus (general): offers a convenient fixed‑ratio insulin formulation for patients requiring both basal and mealtime insulin.

How It Works

  • Insulin Human binds to insulin receptors on muscle, adipose and hepatic cells, activating the receptor’s tyrosine kinase activity. This stimulates glucose uptake, glycogen synthesis and lipogenesis while suppressing hepatic gluconeogenesis, thereby lowering blood glucose levels.

Side Effects

Common Side Effects

  • Hypoglycaemia: low blood glucose episodes, especially if meals are missed or activity is increased.
  • Injection site reactions: redness, swelling or itching at the injection site.
  • Weight gain: increased adipose tissue due to enhanced glucose utilization.
  • Lipodystrophy: localized fat accumulation or loss with repeated injections.
  • Edema: mild peripheral swelling, often transient.
  • Nausea: occasional gastrointestinal discomfort.

Serious or Rare Side Effects

  • Severe hypoglycaemia: can lead to loss of consciousness or seizures.
  • Allergic reactions: including urticaria, angioedema or anaphylaxis.
  • Insulin‑induced edema leading to heart failure exacerbation.
  • Hypokalemia: low potassium levels in rare cases.

Precautions & Warnings

Before using Insuman Comb 30, consider the following precautions:

  • Blood glucose monitoring: adjust dose based on regular self‑monitoring.
  • Illness or stress: may require temporary dose increase.
  • Renal or hepatic impairment: use with caution and monitor closely.
  • Hypoglycaemia unawareness: patients should be educated on recognizing symptoms.
  • Pregnancy and breastfeeding: discuss risks and benefits with a healthcare professional.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Insuman Comb 30 may interact with several drug classes.

Major Interactions (Avoid)

  • Sulfonylureas or meglitinides: combined use can cause severe hypoglycaemia.
  • Beta‑blockers: may mask hypoglycaemia symptoms, requiring closer monitoring.

Moderate Interactions (Monitor Closely)

  • Corticosteroids: can raise blood glucose, possibly necessitating dose adjustment.
  • Thiazide diuretics: may increase insulin resistance and glucose levels.
  • Oral contraceptives: hormonal changes can affect insulin requirements.

Frequently Asked Questions

Insuman Comb 30 is a premixed insulin formulation used to control blood glucose in patients with type 1 or type 2 diabetes mellitus. It provides both rapid‑acting and intermediate‑acting insulin components to manage fasting and post‑meal glucose levels.

Insulin Human mimics natural human insulin by binding to insulin receptors on muscle, fat and liver cells. This triggers cellular pathways that increase glucose uptake, promote glycogen storage, and suppress hepatic glucose production, thereby lowering circulating blood sugar.

The dose of Insuman Comb 30 is individualized. A qualified prescriber determines the total daily insulin requirement, the proportion of basal versus prandial insulin, and the injection schedule based on the patient’s blood‑glucose targets, diet, activity level and clinical response.

Insulin is generally considered the treatment of choice for diabetes in pregnancy because it does not cross the placenta. However, the decision to use Insuman Comb 30 during pregnancy or while breastfeeding should be made by a healthcare professional after evaluating maternal and fetal risks and benefits.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and required import documentation.

Insuman Comb 30 is a premixed 30/70 formulation, meaning it contains 30% rapid‑acting and 70% intermediate‑acting insulin. This differs from basal‑only insulins (e.g., glargine) or rapid‑acting only insulins (e.g., lispro). The premixed format offers convenience for patients who prefer fewer daily injections but provides less flexibility for precise basal‑prandial adjustments.

Insuman Comb 30 should be stored in a refrigerator at 2‑8 °C, protected from light. Do not freeze or shake the vial. Once in use, it may be kept at controlled room temperature (up to 30 °C) for a maximum of 28 days, after which any remaining insulin should be discarded.

Insuman Comb 30 is administered by subcutaneous injection, typically into the abdomen, thigh or upper arm. The injection site should be rotated to avoid lipodystrophy. Patients should follow their prescriber’s instructions regarding dose timing relative to meals and monitor blood glucose regularly.

The most serious risks include severe hypoglycaemia, which can lead to loss of consciousness or seizures, and allergic reactions ranging from rash to anaphylaxis. Patients should be educated on recognizing early signs of hypoglycaemia and instructed to seek immediate medical attention for any suspected allergic response.

Insuman Comb 30 is contraindicated in individuals with a known hypersensitivity to insulin human or any excipients in the formulation. It should also be avoided in patients with severe hypoglycaemia unawareness or those who cannot reliably monitor blood glucose levels.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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