Product image of Insuman Comb 30 (Insulin Human (Rdna)) supplied by GNH India

Insuman Comb 30

Active Ingredient:
Insulin Human (Rdna)
Origin:
EU

Insuman Comb 30 (Insulin Human (Rdna))

Insulin human, the active ingredient in Insuman Comb 30, is an insulin presented as a premixed insulin 30 formulation for subcutaneous use. It treats hyperglycemia in type 1 and type 2 diabetes mellitus, offering both rapid‑acting and intermediate‑acting components to cover mealtime and basal glucose needs.

GNH India supplies Insuman Comb 30 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sanofi-Aventis Deutschland Gmbh

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Indications & Clinical Uses

Insuman Comb 30 is used in the insulin pathway to manage blood glucose in diabetes mellitus.

  • Type 1 diabetes mellitus: provides basal and prandial insulin coverage to lower blood glucose levels.
  • Type 2 diabetes mellitus: assists in achieving glycaemic control when oral agents are insufficient.
  • Hyperglycemia: reduces elevated plasma glucose concentrations.

How It Works

  • Insulin human binds to insulin receptors on muscle, adipose and hepatic cells, activating the receptor’s tyrosine kinase activity. This triggers intracellular signaling cascades that promote glucose uptake, glycogen synthesis, and inhibition of hepatic glucose production, thereby lowering circulating blood glucose levels.

Side Effects

Insuman Comb 30 may be associated with several adverse reactions, which are categorized by frequency.

Common Side Effects

  • Hypoglycaemia: episodes of low blood glucose, especially if meals are missed or activity is increased.
  • Injection‑site reactions: redness, swelling, or itching at the injection site.
  • Weight gain: modest increase in body weight due to improved glucose utilization.
  • Lipodystrophy: localized thickening or loss of subcutaneous fat with repeated injections.
  • Mild allergic response: urticaria or localized rash.

Serious or Rare Side Effects

  • Severe hypoglycaemia: profound low glucose requiring assistance.
  • Anaphylactic reaction: systemic allergic response that can be life‑threatening.
  • Edema: fluid accumulation, particularly in the lower extremities.
  • Insulin antibody formation: may alter insulin effectiveness.
  • Hypokalemia: low potassium levels in rare cases.

Precautions & Warnings

When using Insuman Comb 30, several precautions should be observed to ensure safe therapy.

  • Dose adjustment: tailor the regimen based on regular blood glucose monitoring and individual response.
  • Renal impairment: monitor closely as reduced clearance may increase hypoglycaemia risk.
  • Elderly patients: start with lower doses and titrate slowly to avoid sudden glucose drops.
  • Pregnancy and lactation: use only if the expected benefit outweighs potential risk; consult a specialist.
  • Alcohol consumption: may mask hypoglycaemia symptoms and potentiate low glucose events.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Insuman Comb 30 can interact with other medicines, influencing glucose control or insulin action.

Major Interactions (Avoid)

  • Beta‑blockers: may conceal hypoglycaemia warning signs.
  • MAO inhibitors: unpredictable alterations in blood glucose levels.
  • Alcohol (excessive): can potentiate insulin‑induced hypoglycaemia.

Moderate Interactions (Monitor Closely)

  • Thiazide diuretics: may raise blood glucose concentrations.
  • Corticosteroids: can increase insulin resistance, requiring dose adjustments.
  • Oral hypoglycaemic agents (e.g., sulfonylureas): additive glucose‑lowering effect, increasing hypoglycaemia risk.

Frequently Asked Questions

Insuman Comb 30 is a premixed human insulin indicated to improve glycaemic control in adults with type 1 or type 2 diabetes mellitus. It provides both rapid‑acting and intermediate‑acting insulin components to cover mealtime glucose spikes and basal insulin needs.

Insulin human mimics the action of natural pancreatic insulin. After subcutaneous injection it binds to insulin receptors on muscle, fat and liver cells, activating intracellular pathways that increase glucose uptake, promote glycogen storage, and suppress hepatic glucose production, thereby lowering blood glucose levels.

The dose of Insuman Comb 30 is individualized. A qualified healthcare professional determines the starting amount and subsequent titration based on the patient’s blood‑glucose readings, diet, activity level and overall clinical status. Patients should never adjust the dose without medical guidance.

Insuman Comb 30 may be used in pregnancy or while breastfeeding only when the expected benefit to the mother outweighs potential risks to the fetus or infant. Decisions should be made by the prescribing clinician in consultation with the patient, considering alternative therapies when appropriate.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity of Insuman Comb 30. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and required import documentation.

Insuman Comb 30 contains human insulin in a 30/70 ratio (30% rapid‑acting, 70% intermediate‑acting), similar to other premixed products such as Humulin 30. Differences may lie in manufacturing processes, excipients, and regulatory approvals, but clinical efficacy and safety profiles are generally comparable when dosed appropriately.

Store Insuman Comb 30 at 2‑8 °C (refrigerated) in its original carton, protected from light. Do not freeze or shake the vial or pen. Once in use, it may be kept at room temperature (up to 30 °C) for a maximum of 28 days, after which any remaining product should be discarded.

Insuman Comb 30 is administered by subcutaneous injection, typically into the abdomen, thigh or upper arm. The injection should be given at consistent times relative to meals, and the injection site should be rotated to reduce the risk of lipodystrophy. Proper technique and needle selection are essential for accurate dosing.

The most serious risks include severe hypoglycaemia, which can cause loss of consciousness or seizures, and allergic reactions ranging from local rash to anaphylaxis. Patients should be educated to recognise early signs of low blood glucose and to seek immediate medical attention for any suspected severe allergic response.

Insuman Comb 30 is contraindicated in individuals with a known hypersensitivity to human insulin or any of the product’s excipients. It should also be avoided in patients with severe hypoglycaemia unawareness or those in whom insulin therapy is not indicated, unless a specialist determines that benefits outweigh risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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