Product image of Insuman Comb 30 Solostar (Insulin Human) supplied by GNH India

Insuman Comb 30 Solostar

Active Ingredient:
Insulin Human
Origin:
EU

Insuman Comb 30 Solostar (Insulin Human)

Insulin human, the active ingredient in Insuman Comb 30 Solostar, is an insulin presented as a solution for injection (prefilled pen) for subcutaneous use. It treats diabetes mellitus in both type 1 and type 2 patients.

GNH India supplies Insuman Comb 30 Solostar as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sanofi-Aventis Deutschland Gmbh

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Indications & Clinical Uses

Insuman Comb 30 Solostar is an insulin preparation used in the management of diabetes mellitus and related insulin‑deficiency states.

  • Type 1 diabetes mellitus: provides rapid and intermediate insulin action to achieve glycaemic control.
  • Type 2 diabetes mellitus: supplements endogenous insulin to reach target blood glucose levels.
  • Basal‑bolus insulin regimens: combines short‑acting and protamine‑bound insulin to cover mealtime spikes and basal needs.

How It Works

  • Insulin human binds to insulin receptors on muscle, adipose and hepatic cells, activating the receptor tyrosine kinase pathway. This promotes translocation of GLUT‑4 transporters, increasing glucose uptake, while simultaneously suppressing hepatic gluconeogenesis and glycogenolysis, thereby lowering circulating blood glucose concentrations.

Side Effects

Common Side Effects

  • Hypoglycaemia: symptoms of low blood sugar such as shakiness, sweating, and confusion.
  • Injection site reactions: redness, swelling, or itching at the injection site.
  • Lipodystrophy: localized changes in subcutaneous fat tissue.
  • Weight gain: increase in body weight associated with improved glycaemic control.
  • Localised allergic reactions: mild rash or urticaria.
  • Peripheral oedema: mild swelling of the extremities.

Serious or Rare Side Effects

  • Severe hypoglycaemia: profound low glucose requiring assistance.
  • Anaphylaxis: life‑threatening systemic allergic reaction.
  • Insulin antibodies: may alter insulin action.
  • Hypokalaemia: low serum potassium levels.
  • Stevens‑Johnson syndrome: rare severe skin reaction.
  • Diabetic ketoacidosis: may occur if insulin is omitted.

Precautions & Warnings

Insuman Comb 30 Solostar requires careful clinical monitoring and patient education.

  • Dose titration: adjust based on regular blood glucose measurements.
  • Hypoglycaemia risk: ensure patients recognize symptoms and have rapid‑acting carbohydrate available.
  • Renal impairment: monitor kidney function and consider dose adjustments.
  • Pregnancy: use only when benefits outweigh potential risks.
  • Drug interactions: review all concomitant medications for additive hypoglycaemic potential.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Insuman Comb 30 Solostar may interact with several drug classes.

Major Interactions (Avoid)

  • Concurrent sulfonylureas: increased risk of severe hypoglycaemia.
  • Beta‑blockers: may mask typical hypoglycaemia warning signs.
  • Systemic corticosteroids: may necessitate higher insulin doses.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: can potentiate insulin‑induced hypoglycaemia.
  • Thiazide diuretics: may affect glucose homeostasis.
  • Alcohol: can cause delayed hypoglycaemia, especially with binge drinking.

Frequently Asked Questions

Insuman Comb 30 Solostar is a prefilled insulin pen that delivers insulin human for the treatment of both type 1 and type 2 diabetes mellitus. It provides a combination of rapid‑acting and protamine‑bound insulin to help patients achieve and maintain target blood glucose levels.

Insulin human mimics the body’s natural insulin by binding to insulin receptors on muscle, fat and liver cells. This activates intracellular pathways that increase glucose uptake, reduce hepatic glucose production, and promote storage of glucose as glycogen, thereby lowering blood glucose concentrations.

The dose is individualized by the prescribing healthcare professional based on the patient’s blood glucose readings, carbohydrate intake, activity level, and overall treatment goals. Patients should follow the prescriber’s instructions and regularly monitor glucose to guide any dose adjustments.

Data on insulin human use in pregnancy and lactation are limited. It may be used when the expected benefit to the mother outweighs potential risks to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss use with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain handling) and necessary import documentation.

Insuman Comb 30 Solostar contains human insulin rather than a rapid‑acting analogue. It offers a blend of short‑acting and protamine‑bound insulin, providing both mealtime coverage and basal effect in a single injection. Compared with rapid‑acting analogues, it may have a slightly slower onset but can simplify dosing for some patients.

Store the pen at 2‑8 °C (refrigerated) and protect it from direct light. Do not freeze or shake the pen. Once in use, it may be kept at room temperature (up to 25 °C) for a limited period as indicated in the product insert, but should be discarded after the recommended in‑use time.

The medication is delivered subcutaneously using the prefilled pen. The pen is primed according to the manufacturer’s instructions, the appropriate dose is selected by turning the dose selector, and the needle is inserted into the subcutaneous tissue of the abdomen, thigh or upper arm before injection.

The most serious risks include severe hypoglycaemia, which can cause loss of consciousness or seizures, and rare allergic reactions such as anaphylaxis. Patients should be educated to recognize early signs of low blood sugar and to seek immediate medical attention if a severe reaction occurs.

Individuals with a known hypersensitivity to human insulin or any excipients in the formulation should avoid this product. It is also contraindicated in patients experiencing hypoglycaemia unawareness or those for whom insulin therapy is not indicated. Clinical judgment is required for patients with certain medical conditions, such as severe renal impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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