Product image of Insuman Comb 30 Solostar (Insulin Human) supplied by GNH India

Insuman Comb 30 Solostar

Active Ingredient:
Insulin Human
Origin:
EU

Insuman Comb 30 Solostar (Insulin Human)

Insulin human, the active ingredient in Insuman Comb 30 Solostar, is an insulin presented as a premixed insulin injection solution for subcutaneous use. It is used to manage blood glucose levels in patients with type 1 and type 2 diabetes mellitus.

GNH India supplies Insuman Comb 30 Solostar as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable cold‑chain logistics for biologic products, ensuring timely delivery to healthcare providers across multiple continents.

Manufacturer / TM Owner

Sanofi-Aventis Deutschland Gmbh

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Indications & Clinical Uses

  • Insuman Comb 30 Solostar is a premixed insulin indicated for diabetes mellitus management.
  • Type 1 diabetes mellitus: provides basal and prandial insulin to achieve glycemic control.
  • Type 2 diabetes mellitus: supplies combined rapid‑acting and intermediate‑acting insulin to lower blood glucose.
  • Diabetes mellitus (general): delivers a fixed ratio of short‑ and intermediate‑acting insulin for overall glucose regulation.

How It Works

  • Insulin human binds to insulin receptors on cell membranes, activating the intrinsic tyrosine kinase activity of the receptor. This triggers downstream signaling pathways that promote translocation of glucose transporter‑4 (GLUT‑4) to the cell surface, enhancing glucose uptake in muscle and adipose tissue, while suppressing hepatic gluconeogenesis and glycogenolysis, thereby lowering plasma glucose concentrations.

Side Effects

Insuman Comb 30 Solostar may be associated with several adverse reactions, ranging from frequent to rare.

Common Side Effects

  • Hypoglycemia: low blood glucose episodes.
  • Injection site reactions: redness, swelling, or itching.
  • Weight gain: increase in body weight.
  • Edema: mild fluid retention.

Serious or Rare Side Effects

  • Severe hypoglycemia: seizures or loss of consciousness.
  • Anaphylactic reaction: life‑threatening allergic response.
  • Insulin antibody formation: may alter insulin efficacy.

Precautions & Warnings

When using Insuman Comb 30 Solostar, several precautions should be observed to ensure safety and effectiveness.

  • Blood glucose monitoring: check levels regularly to adjust dose.
  • Dose adjustment during illness: reduce or increase insulin as needed under medical guidance.
  • Avoid use in hypoglycemia: do not administer if blood glucose is already low.
  • Caution in renal impairment: monitor kidney function and adjust dosing.
  • Pregnancy and lactation: safety not established; use only if benefits outweigh risks.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Insuman Comb 30 Solostar can interact with other medicines, affecting glucose control or insulin action.

Major Interactions (Avoid)

  • Sulfonylureas: additive risk of severe hypoglycemia.
  • Beta‑adrenergic blockers: may mask hypoglycemia symptoms.
  • ACE inhibitors: can potentiate insulin’s glucose‑lowering effect.

Moderate Interactions (Monitor Closely)

  • Thiazide diuretics: may increase blood glucose levels.
  • Corticosteroids: can raise glucose, requiring dose adjustments.
  • Alcohol: can cause unpredictable glucose fluctuations.

Frequently Asked Questions

Insuman Comb 30 Solostar is a premixed insulin formulation used to control blood glucose levels in adults with type 1 or type 2 diabetes mellitus. It provides both rapid‑acting and intermediate‑acting insulin components to cover basal needs and mealtime spikes.

Insulin human mimics the natural hormone insulin. It binds to insulin receptors on muscle, fat and liver cells, activating signaling pathways that move glucose‑transport proteins to the cell surface, increase glucose uptake, and suppress liver glucose production, thereby lowering circulating glucose.

The dose of Insuman Comb 30 Solostar is individualized by the prescribing healthcare professional based on the patient’s blood‑glucose profile, diet, activity level and other medications. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for insulin human in pregnancy and lactation are limited. It may be used only if the potential benefits to the mother outweigh any possible risks to the fetus or infant, and under close medical supervision.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain handling) and necessary import documentation.

Insuman Comb 30 Solostar contains human insulin in a fixed 30/70 ratio of rapid‑acting to intermediate‑acting components, similar to other premixed products such as NovoRapid Mix 30. Clinical efficacy and safety are comparable, but formulation differences (human vs. analog insulin) may influence individual patient response and hypoglycemia risk.

The product must be stored at 2‑8 °C (refrigerated) in its original carton, protected from light. Do not freeze or shake the vial. Once in use, it may be kept at room temperature for a limited period as indicated on the label, but should be discarded after the recommended in‑use time.

Insuman Comb 30 Solostar is given by subcutaneous injection, typically into the abdomen, thigh or upper arm. The injection site should be rotated to avoid lipodystrophy. Patients should be trained on proper technique, needle length, and timing relative to meals as directed by their healthcare provider.

The most serious risks include severe hypoglycemia, which can lead to seizures or loss of consciousness, and allergic reactions such as anaphylaxis. Rarely, patients may develop insulin antibodies that alter drug effectiveness. Prompt medical attention is required if any of these events occur.

Patients with known hypersensitivity to human insulin or any excipients in the formulation should avoid this product. It is also contraindicated in individuals experiencing hypoglycemia at the time of dosing, and caution is advised for those with severe renal or hepatic impairment until evaluated by a clinician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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