Product image of Insuman Comb 30 Solostar (Insulin Human (Rdna)) supplied by GNH India

Insuman Comb 30 Solostar

Active Ingredient:
Insulin Human (Rdna)
Origin:
EU

Insuman Comb 30 Solostar (Insulin Human (Rdna))

Insulin Human, the active ingredient in Insuman Comb 30 Solostar, is an insulin presented as a subcutaneous solution for subcutaneous use. It is used to control blood glucose in patients with diabetes mellitus, both type 1 and type 2.

GNH India supplies Insuman Comb 30 Solostar as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑compliant shipments to global markets.

Manufacturer / TM Owner

Sanofi-Aventis Deutschland Gmbh

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Indications & Clinical Uses

Insuman Comb 30 Solostar is an insulin preparation indicated for the management of diabetes mellitus, targeting both basal and prandial glucose control.

  • Type 1 diabetes mellitus: provides basal and mealtime insulin to achieve glycemic control.
  • Type 2 diabetes mellitus: used when oral agents are insufficient, offering combined basal‑bolus coverage.
  • Insulin‑deficient states: supplies patients requiring exogenous insulin to replace deficient endogenous secretion.

How It Works

  • Insulin Human binds to insulin receptors on muscle, adipose and hepatic cells, activating the receptor’s intrinsic tyrosine kinase activity. This triggers intracellular signaling cascades that promote translocation of GLUT‑4 transporters, enhancing glucose uptake, and suppresses hepatic gluconeogenesis, thereby lowering blood glucose levels. The formulation combines rapid‑acting and protaminated insulin to provide both immediate and prolonged action.

Side Effects

Insuman Comb 30 Solostar may be associated with several adverse reactions, ranging from frequent to rare.

Common Side Effects

  • Hypoglycemia: low blood glucose episodes, especially if meals are missed.
  • Injection site reactions: redness, swelling, or itching at the injection site.
  • Weight gain: increase in body weight due to improved glucose utilization.
  • Lipodystrophy: localized fat tissue changes at injection sites.
  • Edema: mild peripheral swelling.
  • Nausea: occasional gastrointestinal discomfort.

Serious or Rare Side Effects

  • Severe hypoglycemia: neurological symptoms or loss of consciousness.
  • Anaphylactic reaction: life‑threatening allergy requiring immediate medical attention.
  • Insulin allergy: systemic rash, urticaria, or angioedema.
  • Serum sickness–like reaction: fever, arthralgia, and rash.
  • Hypokalemia: low potassium levels, especially with high doses.
  • Seizures: secondary to profound hypoglycemia.

Precautions & Warnings

When using Insuman Comb 30 Solostar, several precautions should be observed to ensure safe and effective therapy.

  • Dose adjustment: tailor insulin dose to individual blood‑glucose monitoring results.
  • Renal impairment: monitor closely as reduced clearance may increase hypoglycemia risk.
  • Hepatic impairment: use with caution; altered metabolism may affect glucose control.
  • Pregnancy: limited safety data; evaluate risk‑benefit before prescribing.
  • Hypoglycemia risk: educate patients on recognizing and treating low blood glucose.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Insuman Comb 30 Solostar can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Concurrent sulfonylureas: additive hypoglycemia risk.
  • Beta‑blockers: may mask hypoglycemia symptoms.
  • Alcohol: can potentiate insulin’s glucose‑lowering effect.

Moderate Interactions (Monitor Closely)

  • Thiazide diuretics: may increase blood glucose, requiring dose adjustment.
  • Corticosteroids: can raise glucose levels, potentially necessitating higher insulin doses.
  • ACE inhibitors: may affect potassium balance, warranting monitoring.

Frequently Asked Questions

Insuman Comb 30 Solostar is a recombinant human insulin indicated for the treatment of diabetes mellitus. It provides both basal and prandial insulin coverage, helping patients with type 1 or type 2 diabetes achieve target blood‑glucose levels when diet, exercise, or oral agents alone are insufficient.

Insulin human binds to insulin receptors on muscle, fat and liver cells, activating intracellular pathways that increase glucose uptake via GLUT‑4 transporters and suppress hepatic glucose production. The combined rapid‑acting and protaminated components give an initial glucose‑lowering effect followed by a prolonged basal action.

The dose of Insuman Comb 30 Solostar is individualized. A qualified prescriber determines the total daily units based on the patient’s blood‑glucose readings, carbohydrate intake, activity level and other therapies. No fixed regimen is provided; dosing is adjusted over time to meet therapeutic goals.

Safety data for insulin human in pregnancy and lactation are limited. It may be used when the potential benefit outweighs any possible risk to the fetus or infant. Clinicians should evaluate each case, monitor glucose closely, and discuss potential risks with the patient.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain logistics) and any necessary import documentation.

Insuman Comb 30 Solostar combines rapid‑acting and protaminated insulin, offering a basal‑bolus profile in a single preparation. Compared with long‑acting analogues such as insulin glargine, it provides a quicker onset but a shorter duration of basal effect, which may be preferred for patients needing flexible dosing or rapid post‑prandial control.

The product must be stored refrigerated at 2‑8 °C, protected from light, and must not be frozen or shaken. Once in use, it can be kept at controlled room temperature (up to 25 °C) for a limited period as indicated in the package insert, but any unused portion should be discarded after the recommended time.

Insuman Comb 30 Solostar is given by subcutaneous injection, typically into the abdomen, thigh or upper arm. Injection sites should be rotated to reduce lipodystrophy. Patients should be instructed on proper technique, needle length, and timing relative to meals to achieve optimal glucose control.

The most serious risks include severe hypoglycemia, which can lead to seizures, loss of consciousness or death, and allergic reactions such as anaphylaxis. Patients should be educated to recognize early signs of low blood glucose and to seek immediate medical attention for any signs of a severe allergic response.

Insuman Comb 30 Solostar is contraindicated in individuals with a known hypersensitivity to human insulin or any of the product’s excipients. It should also be avoided in patients who have experienced severe allergic reactions to insulin preparations. Caution is advised in those with renal or hepatic impairment, and use should be supervised by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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