Product image of Insuman Comb 50 (Insulin Human) supplied by GNH India

Insuman Comb 50

Active Ingredient:
Insulin Human
Origin:
EU

Insuman Comb 50 (Insulin Human)

Insulin human, the active ingredient in Insuman Comb 50, is a insulin presented as a 50 U/mL premixed insulin injection for subcutaneous use. It treats diabetes mellitus in both type 1 and type 2 patients.\n\nGNH India supplies Insuman Comb 50 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory compliance.

Manufacturer / TM Owner

Sanofi-Aventis Deutschland Gmbh

1
Pack/s
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Indications & Clinical Uses

  • Insuman Comb 50 is a premixed insulin indicated for diabetes mellitus management, providing both basal and prandial glucose control.\n\n- Type 1 diabetes mellitus: supplies both rapid‑acting and intermediate‑acting insulin in a fixed 1:1 ratio to simplify multiple daily injections and achieve basal‑prandial control.\n- Type 2 diabetes mellitus: used when oral hypoglycemics no longer maintain target glucose, providing combined basal and mealtime insulin in a single injection.

How It Works

  • Insuman Comb 50 contains human insulin, a peptide that binds to insulin receptors on muscle, adipose and hepatic cells. Receptor activation triggers the tyrosine kinase cascade, promoting translocation of GLUT‑4 transporters and enhancing glucose uptake, while simultaneously suppressing hepatic gluconeogenesis. The formulation combines soluble insulin (rapid onset) with isophane insulin (intermediate duration) to provide both prandial and basal activity.

Side Effects

  • The following adverse reactions have been reported with Insuman Comb 50.\n\nCommon Side Effects:\n- Hypoglycemia: episodes of low blood glucose that may cause shakiness, sweating, confusion or loss of consciousness if untreated.\n- Injection site reactions: redness, swelling, itching or bruising at the subcutaneous injection site.\n- Weight gain: gradual increase in body weight associated with improved glycemic control and insulin’s anabolic effects.\n- Lipodystrophy: localized thickening or atrophy of subcutaneous fat tissue due to repeated injections.\n\nSerious or Rare Side Effects:\n- Allergic reactions: urticaria, angioedema or anaphylactic shock requiring immediate medical attention.\n- Severe hypoglycemia: profound low glucose levels leading to seizures, coma or loss of consciousness.\n- Edema: peripheral or generalized fluid retention that may be accompanied by shortness of breath.

Precautions & Warnings

  • When using Insuman Comb 50, consider the following precautions.\n\n- Dose individualization: titrate based on blood glucose monitoring and clinical response.\n- Hypoglycemia risk: educate patients on recognizing and treating low glucose.\n- Renal impairment: monitor closely as insulin clearance may be reduced.\n- Pregnancy and lactation: use only if benefits outweigh potential risks; consult healthcare provider.\n- Concomitant medications: assess for agents that may potentiate hypoglycemia (e.g., sulfonylureas).\n- Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

  • Insuman Comb 50 may interact with other medicines.\n\nMajor Interactions (Avoid):\n- Beta‑blockers: may mask hypoglycemia symptoms.\n- MAO inhibitors: can potentiate insulin’s glucose‑lowering effect.\n- High‑dose corticosteroids: may cause significant hyperglycemia requiring dose adjustment.\n\nModerate Interactions (Monitor Closely):\n- Oral antidiabetic agents (e.g., sulfonylureas, meglitinides): increased risk of hypoglycemia.\n- Thiazide diuretics: may raise blood glucose levels.\n- ACE inhibitors: may enhance insulin sensitivity, requiring monitoring.

Frequently Asked Questions

Insuman Comb 50 is a premixed insulin formulation indicated for the management of blood glucose in adults with type 1 or type 2 diabetes mellitus. It provides both rapid‑acting and intermediate‑acting insulin in a single injection to simplify dosing and achieve basal‑prandial control.

Insulin human is a synthetic version of the body’s natural insulin. It binds to insulin receptors on muscle, fat and liver cells, activating a signaling cascade that promotes glucose uptake, storage as glycogen, and reduces hepatic glucose production, thereby lowering blood glucose levels.

The dose of Insuman Comb 50 is individualized by the prescribing healthcare professional based on the patient’s blood glucose readings, diet, activity level and overall treatment goals. Patients should follow the dosing regimen set by their prescriber and adjust only under medical supervision.

Insulin is generally considered the treatment of choice for diabetes during pregnancy because it does not cross the placenta in harmful amounts. However, the safety of Insuman Comb 50 specifically should be evaluated by a healthcare provider, and the benefits must outweigh any potential risks.

To order Insuman Comb 50, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and necessary import documentation.

Insuman Comb 50 is a premixed 1:1 combination of soluble (rapid‑acting) and isophane (intermediate‑acting) insulin, offering the convenience of a single daily injection for patients who need both basal and prandial coverage. Compared with basal‑only or rapid‑acting‑only insulins, it reduces injection frequency but provides less flexibility for precise dose adjustments.

Store Insuman Comb 50 at 2‑8 °C (refrigerated) in its original carton, protected from light. Do not freeze or shake the vial. If needed for short‑term use, it may be kept at controlled room temperature (up to 25 °C) for a maximum of 28 days, but refrigeration is preferred.

Insuman Comb 50 is administered by subcutaneous injection, typically into the abdomen, thigh or upper arm. The injection site should be rotated with each dose to reduce the risk of lipodystrophy. Patients must be trained on proper technique, needle length, and timing relative to meals.

The most serious risks include severe hypoglycemia, which can lead to seizures, loss of consciousness or coma, and allergic reactions such as anaphylaxis. Patients should be educated to recognize early signs of low blood glucose and to seek immediate medical help if a severe reaction occurs.

Insuman Comb 50 should not be used by individuals with a known hypersensitivity to human insulin or any of the excipients in the formulation. It is also contraindicated in patients experiencing hypoglycemia at the time of administration. Clinical judgment is required for patients with certain endocrine disorders or severe renal impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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