Product image of Insuman Infusat (Insulin Human) supplied by GNH India

Insuman Infusat

Active Ingredient:
Insulin Human
Origin:
EU

Insuman Infusat (Insulin Human)

Insulin Human, the active ingredient in Insuman Infusat, is an insulin presented as a sterile solution for subcutaneous use. It replaces deficient endogenous insulin and helps control blood glucose levels in individuals with type 1 or type 2 diabetes mellitus.

GNH India supplies Insuman Infusat as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and pharmacies worldwide, adhering to stringent quality standards and providing reliable global distribution. The company offers comprehensive support for regulatory documentation and cold‑chain logistics where required. Clients benefit from dedicated technical assistance and timely delivery.

Manufacturer / TM Owner

Sanofi-Aventis Deutschland Gmbh

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Indications & Clinical Uses

Insuman Infusat, a human insulin, acts on the insulin pathway to regulate glucose metabolism in diabetes.

  • Type 1 Diabetes Mellitus: provides basal insulin to maintain glucose control.
  • Type 2 Diabetes Mellitus: used when oral agents are insufficient to achieve target glycaemia.
  • Diabetic Ketoacidosis: administered for rapid reduction of hyperglycemia.
  • Hospitalized Hyperglycemia: used to manage elevated blood glucose in acute care settings.

How It Works

  • Insuman Infusat contains recombinant human insulin that binds to insulin receptors on cell membranes, activating the intrinsic tyrosine kinase activity. This triggers downstream signaling cascades, promoting translocation of glucose transporter‑4 to the cell surface, enhancing glucose uptake in muscle and adipose tissue, and suppressing hepatic gluconeogenesis, thereby lowering circulating glucose concentrations. The effect persists for several hours, providing basal insulin coverage.

Side Effects

Insuman Infusat may be associated with several adverse reactions, ranging from frequent to rare.

Common Side Effects

  • Hypoglycemia: low blood sugar episodes, especially if dosage exceeds needs.
  • Injection site reactions: redness, swelling, or itching at the injection site.
  • Weight gain: modest increase in body weight due to improved glucose utilization.

Serious or Rare Side Effects

  • Severe hypoglycemia with loss of consciousness or seizures.
  • Allergic reactions: anaphylaxis, urticaria, or angioedema.
  • Lipodystrophy: abnormal fat accumulation or loss at injection sites.

Precautions & Warnings

Before initiating Insuman Infusat therapy, consider the following precautions to ensure safe and effective use.

  • Dose adjustment: modify dose in renal or hepatic impairment to avoid hypoglycemia.
  • Blood glucose monitoring: frequent checks are essential during dose changes or illness.
  • Hypoglycemia risk: do not administer if patient is already hypoglycemic.
  • Pregnancy and lactation: use only if benefits outweigh potential risks.
  • Allergy: avoid if known hypersensitivity to human insulin or excipients.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Insuman Infusat can interact with other medicines, influencing its glucose‑lowering effect or safety profile.

Major Interactions (Avoid)

  • Beta‑blockers: may mask hypoglycemia symptoms, requiring careful monitoring.
  • Alcohol: can potentiate insulin’s hypoglycemic action, increasing risk of low blood sugar.
  • MAO inhibitors: may enhance insulin’s effect, leading to severe hypoglycemia.

Moderate Interactions (Monitor Closely)

  • Sulfonylureas: additive glucose‑lowering effect, may cause hypoglycemia.
  • Thiazide diuretics: can increase blood glucose, potentially reducing insulin efficacy.
  • Corticosteroids: may raise glucose levels, necessitating dose adjustments.

Frequently Asked Questions

Insuman Infusat is a human insulin indicated for the management of diabetes mellitus, including type 1 and type 2, and for control of hyperglycemia in acute settings such as diabetic ketoacidosis or hospitalized patients. It provides basal insulin replacement to help maintain target blood glucose levels.

Insulin Human is a recombinant form of the hormone insulin that binds to insulin receptors on muscle, fat, and liver cells. This binding activates intracellular signaling that promotes glucose transporter‑4 translocation, increases glucose uptake, and suppresses hepatic glucose production, thereby lowering circulating glucose concentrations.

The dose of Insuman Infusat is individualized and determined by the prescribing healthcare professional based on the patient’s age, weight, type of diabetes, current glycemic control, and concurrent therapies. The prescriber calculates the appropriate units per injection and may adjust the regimen over time according to blood glucose monitoring.

Safety of Insuman Infusat during pregnancy or lactation has not been definitively established. Insulin is generally considered the preferred glucose‑lowering therapy for pregnant women with diabetes, but the decision to use this product should be made by the treating physician after weighing potential benefits against any unknown risks.

To request Insuman Infusat, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details—including cold‑chain logistics if needed—and assistance with import documentation.

Insuman Infusat contains recombinant human insulin, which has a pharmacokinetic profile similar to endogenous insulin and differs from rapid‑acting analogues that have modified amino‑acid sequences for faster onset. Compared with insulin analogues, human insulin may have a slightly longer onset and duration, making it suitable for basal coverage but potentially requiring more frequent dosing adjustments.

Insuman Infusat should be stored in a refrigerator at 2 °C to 8 °C, protected from light and moisture. Do not freeze the product; if it becomes frozen, discard it. Once in use, the vial may be kept at room temperature (up to 30 °C) for a maximum of 28 days, and the needle‑syringe should be used promptly to maintain sterility.

Insuman Infusat is administered by subcutaneous injection, typically into the abdomen, thigh, or upper arm. The injection site should be rotated to reduce the risk of lipodystrophy. The prescriber determines the injection volume and frequency, which may range from once daily to multiple daily doses depending on the patient’s insulin requirements.

The most serious risks associated with Insuman Infusat include severe hypoglycemia, which can cause loss of consciousness, seizures, or coma, and allergic reactions such as anaphylaxis, urticaria, or angioedema. Patients should be educated to recognize early signs of low blood sugar and to seek immediate medical attention if an allergic response occurs.

Insuman Infusat is contraindicated in individuals with a known hypersensitivity to human insulin or any of its excipients. It should also be avoided in patients experiencing hypoglycemia until glucose levels are corrected, and in those with severe renal or hepatic failure where dose adjustment may be insufficient to prevent adverse effects.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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