Product image of Intertos (Dextromethorphan Hydrobromide) supplied by GNH India

Intertos

Active Ingredient:
Dextromethorphan Hydrobromide
Origin:
EU

Intertos (Dextromethorphan Hydrobromide)

Dextromethorphan, the active ingredient in Intertos, is a cough suppressant presented as an oral formulation for oral use. It is used to relieve non‑productive cough in adults and children when a dry cough interferes with daily activities or sleep. It works by modulating the cough reflex in the brain and is available without a prescription in the European market.

GNH India supplies Intertos as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory compliance.

Manufacturer / TM Owner

Interpharma, S.A.

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Indications & Clinical Uses

Dextromethorphan is an antitussive that acts on the central cough reflex.

  • Non‑productive cough: reduces cough frequency and severity in dry cough conditions.
  • Upper respiratory tract infection cough: provides symptomatic relief of irritation‑induced cough.
  • Acute bronchitis cough: helps suppress a dry cough associated with bronchial inflammation.

How It Works

  • Dextromethorphan acts as a sigma‑1 receptor agonist and an NMDA receptor antagonist in the central nervous system. By modulating these receptors, it diminishes the transmission of cough signals in the brainstem, thereby suppressing the cough reflex without affecting normal respiratory function.

Side Effects

Dextromethorphan may cause a range of adverse reactions.

Common Side Effects

  • Drowsiness: mild sedation or feeling of sleepiness.
  • Dizziness: sensation of light‑headedness or unsteadiness.
  • Nausea: upset stomach or urge to vomit.
  • Vomiting: expulsion of stomach contents.
  • Constipation: reduced bowel movements.
  • Dry mouth: decreased salivation.

Serious or Rare Side Effects

  • Allergic reactions: rash, itching, swelling, or hives.
  • Hallucinations or psychotic symptoms: visual or auditory disturbances.
  • Respiratory depression: slowed breathing at high doses.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Seizures: rare occurrence of convulsive episodes.

Precautions & Warnings

When using Intertos, consider the following precautions.

  • Pregnancy: Category B1; use only if clearly needed after risk assessment.
  • Asthma or COPD: Caution in patients with underlying respiratory disorders.
  • Alcohol consumption: Avoid or limit alcohol as it may increase sedation.
  • Driving and machinery: Do not operate vehicles or heavy equipment if drowsy.
  • Children under 12 years: Use only under medical supervision.
  • Store at ambient temperature: keep in the original pack, protect from moisture and light.

Avoid Interactions

Dextromethorphan can interact with several medicines.

Major Interactions (Avoid)

  • MAO inhibitors: risk of severe hypertension.
  • CNS depressants (e.g., opioids, benzodiazepines): additive sedation and respiratory depression.
  • SSRIs or SNRIs: potential for serotonin syndrome.

Moderate Interactions (Monitor Closely)

  • Antihistamines: may increase drowsiness.
  • Alcohol: enhances central nervous system depression.
  • Ritonavir: may raise dextromethorphan plasma concentrations.

Frequently Asked Questions

Intertos contains dextromethorphan and is used as an over‑the‑counter antitussive to suppress non‑productive, dry coughs that interfere with daily activities or sleep. It provides symptomatic relief by acting on the central cough reflex.

Dextromethorphan acts as a sigma‑1 receptor agonist and an NMDA receptor antagonist in the brainstem. This dual action reduces the transmission of cough signals, thereby lowering the frequency and intensity of the cough without affecting normal breathing.

The appropriate dose of Intertos is determined by the prescribing healthcare professional based on the patient’s age, weight, and clinical condition. Patients should follow the prescriber’s instructions and the product label for safe use.

Intertos is classified as pregnancy category B1, indicating that animal studies have not shown risk and there are no adequate human studies. It should be used only if clearly needed, and breastfeeding mothers should consult a healthcare provider before use.

To order Intertos, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Intertos (dextromethorphan) is a non‑opioid antitussive, whereas codeine is an opioid that also suppresses cough but carries a higher risk of dependence, respiratory depression and stricter regulatory control. Dextromethorphan is generally available OTC and has a more favorable safety profile for short‑term use.

Store Intertos at ambient temperature, below 25 °C, in its original packaging. Keep it away from moisture, direct sunlight and heat sources. Ensure the container is tightly closed to maintain product stability.

Intertos is taken orally, usually as a tablet or liquid formulation, as directed by a healthcare professional. It should be swallowed with water and not chewed unless the product specifically states otherwise.

Serious risks include allergic reactions such as rash or swelling, hallucinations or other psychotic symptoms, severe respiratory depression at high doses, rare skin reactions like Stevens‑Johnson syndrome, and seizures. Patients experiencing any of these should seek immediate medical attention.

Intertos should be avoided in individuals with known hypersensitivity to dextromethorphan, those taking MAO inhibitors, patients with uncontrolled asthma or severe COPD, and children under the age recommended on the product label unless a physician advises otherwise.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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