Product image of Intestal (Bismuth Subsalicylate) supplied by GNH India

Intestal

Active Ingredient:
Bismuth Subsalicylate
Origin:
EU

Intestal (Bismuth Subsalicylate)

Bismuth subsalicylate, the active ingredient in Intestal, is an antidiarrheal presented as an oral formulation for oral use and available over‑the‑counter. It is employed to relieve diarrhea, nausea, heartburn, indigestion and gastritis in adults and children when appropriate.

GNH India supplies Intestal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, adhering to stringent quality and regulatory standards for global distribution.

Manufacturer / TM Owner

Meditop Pharmaceutical Co. Ltd.

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Indications & Clinical Uses

Intestal (bismuth subsalicylate) is used to manage gastrointestinal disturbances that involve excess fluid secretion or irritation.

  • Diarrhea: reduces stool frequency and liquidity by adsorbing toxins and bacteria.
  • Nausea: soothes stomach lining and diminishes nausea sensations.
  • Heartburn: provides antacid action that neutralises excess gastric acid.
  • Indigestion: coats the mucosa to alleviate discomfort after meals.
  • Gastritis: diminishes inflammation and protects irritated gastric tissue.

How It Works

  • Bismuth subsalicylate acts locally in the gastrointestinal tract by adsorbing bacterial toxins and pathogens, forming a protective coating on the mucosal surface, exerting anti‑inflammatory and antacid effects, and inhibiting prostaglandin synthesis, which together reduce fluid secretion and irritation.

Side Effects

Intestal may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Darkened tongue or mouth lining.
  • Blackened stools.
  • Constipation.
  • Nausea.
  • Abdominal discomfort.

Serious or Rare Side Effects

  • Allergic reactions such as rash, swelling or difficulty breathing.
  • Severe constipation leading to bowel obstruction.
  • Persistent black discoloration of the oral cavity.
  • Blood in stool.
  • Rare cases of Stevens‑Johnson syndrome.

Precautions & Warnings

Before using Intestal, consider the following safety measures.

  • Pregnancy: consult a healthcare professional as safety has not been established.
  • Breastfeeding: avoid unless advised by a clinician.
  • Renal impairment: use with caution and monitor renal function.
  • Concurrent salicylate therapy: increased risk of salicylate toxicity.
  • Known hypersensitivity: do not use if allergic to bismuth or salicylates.
  • Store at room temperature: keep in the original container, protect from moisture and heat.

Avoid Interactions

Intestal can interact with other medicines; some combinations should be avoided while others require monitoring.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): may increase bleeding risk.
  • Methotrexate: potential for heightened toxicity.
  • Tetracycline antibiotics: reduced absorption of both agents.

Moderate Interactions (Monitor Closely)

  • Other antacids: may alter gastric pH and affect coating action.
  • Iron supplements: may diminish efficacy of bismuth subsalicylate.
  • Proton pump inhibitors: could affect the drug's protective coating function.

Frequently Asked Questions

Intestal contains bismuth subsalicylate and is indicated for the symptomatic relief of diarrhea, nausea, heartburn, indigestion and gastritis. It works locally in the gastrointestinal tract to reduce irritation, fluid loss and discomfort associated with these common digestive disturbances.

Bismuth subsalicylate adsorbs bacterial toxins and pathogens, creates a protective coating on the stomach and intestinal lining, exerts anti‑inflammatory and antacid effects, and inhibits prostaglandin synthesis. These actions together lessen fluid secretion, neutralise excess acid and soothe irritated mucosa.

The appropriate dose of Intestal is determined by a prescriber based on the patient’s age, condition severity and clinical response. Over‑the‑counter formulations typically provide dosing guidance on the label, but the exact regimen should always follow the healthcare professional’s recommendation.

Safety of bismuth subsalicylate in pregnancy and lactation has not been definitively established. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Intestal.

To order Intestal, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

The primary alternative to bismuth subsalicylate is loperamide, a peripheral opioid that slows intestinal motility. Intestal works locally by adsorbing toxins and providing a protective coating, whereas loperamide reduces stool frequency by decreasing gut movement. Choice depends on the clinical situation, patient tolerance and physician preference.

Intestal should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and excessive heat. Keep the container tightly closed and out of reach of children. No refrigeration is required for this oral formulation.

Intestal is taken orally, usually with a glass of water. The tablet or chewable form can be swallowed whole or chewed, depending on the product instructions. It is generally recommended to take the dose after meals or as directed by a healthcare professional.

Serious adverse reactions, although rare, include allergic responses such as rash, swelling, or difficulty breathing, severe constipation that may lead to bowel obstruction, and persistent black discoloration of the oral cavity or stool. If any of these occur, discontinue the product and seek medical attention promptly.

Intestal should be avoided in individuals with known hypersensitivity to bismuth, salicylates or any component of the formulation. It is also contraindicated in patients with severe renal impairment unless specifically advised by a physician, and should not be used in children receiving aspirin therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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