Product image of Intiflor (Fluconazole) supplied by GNH India

Intiflor

Active Ingredient:
Fluconazole
Origin:
EU

Intiflor (Fluconazole)

Fluconazole, the active ingredient in Intiflor, is a triazole antifungal presented as an oral tablet for oral use. It treats a range of fungal infections and is prescribed for both adult and pediatric patients as appropriate.
GNH India supplies Intiflor as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Meditop Pharmaceutical Co. Ltd.

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Indications & Clinical Uses

Fluconazole is a triazole antifungal that acts on yeast and mold infections.

  • Vulvovaginal candidiasis: relieves symptoms and eradicates the yeast infection.
  • Oropharyngeal candidiasis: clears yeast overgrowth in the mouth and throat.
  • Systemic candidiasis: treats invasive Candida infections in the bloodstream and organs.
  • Cryptococcal meningitis (maintenance therapy): prevents recurrence of fungal meningitis after initial treatment.

How It Works

  • Fluconazole inhibits the fungal cytochrome P450 enzyme 14α‑demethylase, a key step in ergosterol synthesis. By blocking ergosterol production, the drug disrupts the fungal cell membrane, leading to increased permeability and inhibition of fungal growth. This targeted action provides broad activity against Candida species and certain other pathogenic fungi.

Side Effects

Fluconazole may cause a variety of adverse reactions, ranging from mild to severe.

Common Side Effects

  • Nausea
  • Headache
  • Abdominal pain or discomfort
  • Diarrhea
  • Rash or mild skin irritation
  • Altered taste sensation

Serious or Rare Side Effects

  • Severe liver injury or hepatitis
  • Stevens‑Johnson syndrome and toxic epidermal necrolysis
  • Anaphylactic or severe allergic reactions
  • Blood dyscrasias such as neutropenia or thrombocytopenia
  • QT interval prolongation leading to cardiac arrhythmias
  • Severe skin reactions including drug rash with eosinophilia and systemic symptoms (DRESS).

Precautions & Warnings

Before initiating fluconazole therapy, consider the following safety measures.

  • Renal impairment: assess kidney function and adjust dose if necessary.
  • Hepatic impairment: monitor liver enzymes regularly during treatment.
  • Drug interactions: review all concomitant medications for potential interactions.
  • Pregnancy: use only if the potential benefit justifies the potential risk to the fetus.
  • Elderly patients: observe for increased susceptibility to toxicity and adverse effects.
  • Store at ambient temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Fluconazole can interact with several medicines, requiring careful management.

Major Interactions (Avoid)

  • Ritonavir and other protease inhibitors: may markedly increase fluconazole plasma levels.
  • Terbinafine: combined use raises the risk of hepatotoxicity.
  • Cisapride: co‑administration can lead to dangerous QT prolongation.
  • Other azole antifungals (e.g., ketoconazole): may cause additive toxicity.

Moderate Interactions (Monitor Closely)

  • Warfarin: fluconazole can enhance anticoagulant effect, increasing INR.
  • Phenytoin: may reduce fluconazole concentrations, diminishing efficacy.
  • Oral hypoglycemic agents: risk of enhanced hypoglycemia.
  • Statins (especially simvastatin): increased risk of myopathy and rhabdomyolysis.

Frequently Asked Questions

Intiflor contains fluconazole, which is prescribed for a variety of fungal infections such as vulvovaginal and oropharyngeal candidiasis, systemic candidiasis, and as maintenance therapy for cryptococcal meningitis. The specific indication depends on the clinical assessment made by a qualified healthcare professional.

Fluconazole blocks the fungal enzyme 14α‑demethylase, preventing the synthesis of ergosterol, an essential component of the fungal cell membrane. Without ergosterol, the membrane becomes defective, leading to inhibited growth and eventual death of the fungus.

The dosage of Intiflor is determined by the prescribing clinician based on the type and severity of the infection, patient age, weight, and renal or hepatic function. Patients should follow the exact dosing instructions provided by their healthcare provider.

Safety data for fluconazole in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss risks with their doctor.

To request Intiflor, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will ask for trade or institutional credentials. The sales team will then reply with pricing, availability, shipping details and any required import documentation.

Fluconazole, the active ingredient in Intiflor, is a triazole antifungal offering oral administration, good bioavailability, and a broad spectrum against Candida species. Compared with polyene agents like amphotericin B, fluconazole has fewer infusion‑related toxicities but may be less effective against resistant molds. Choice of therapy depends on the pathogen, infection site and patient factors.

Intiflor should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture and direct sunlight, and ensure the packaging remains tightly closed until use.

Intiflor is taken orally, usually as a tablet swallowed with water. The exact timing (e.g., with food or on an empty stomach) and frequency are determined by the prescribing clinician based on the infection being treated.

Serious adverse effects, though rare, include severe liver injury, life‑threatening skin reactions such as Stevens‑Johnson syndrome, anaphylaxis, and cardiac arrhythmias due to QT prolongation. Patients should seek immediate medical attention if they notice jaundice, rash, fever, or palpitations while on therapy.

Intiflor is contraindicated in individuals with known hypersensitivity to fluconazole or any other azole antifungal. Caution is also advised for patients with significant liver disease, severe renal impairment, or those taking medications that have major interactions with fluconazole.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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