Product image of Intigyne (Lactobacillus Gasseri Dsm 14869, Lactobacillus Rhamnosus Dsm 14870) supplied by GNH India

Intigyne

Active Ingredient:
Lactobacillus Gasseri Dsm 14869, Lactobacillus Rhamnosus Dsm 14870
Origin:
EU

Intigyne (Lactobacillus Gasseri Dsm 14869, Lactobacillus Rhamnosus Dsm 14870)

Lactobacillus gasseri DSM 14869 and Lactobacillus rhamnosus DSM 14870, the active ingredients in Intigyne, are probiotic strains presented as a vaginal probiotic formulation for vaginal use. It supports the natural vaginal microbiota and may help maintain balance in women.

GNH India supplies Intigyne as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Biocodex Benelux Nv/Sa

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Indications & Clinical Uses

Intigyne, a vaginal probiotic, is used to support the normal vaginal microbiome and address conditions related to microbial imbalance.

  • Bacterial vaginosis: helps restore lactobacilli dominance and reduce recurrence.
  • Recurrent vulvovaginal candidiasis: may aid in maintaining a protective flora that limits yeast overgrowth.
  • Post‑antibiotic therapy: assists in re‑establishing healthy vaginal bacteria after systemic antibiotics.

How It Works

  • The Lactobacillus gasseri and Lactobacillus rhamnosus strains colonize the vaginal epithelium, where they produce lactic acid, hydrogen peroxide and bacteriocins. This lowers vaginal pH, creates an inhospitable environment for pathogenic bacteria and yeasts, and promotes adhesion of beneficial microbes, thereby helping to maintain a balanced vaginal ecosystem.

Side Effects

Intigyne is generally well tolerated, but some users may experience mild adverse reactions.

Common Side Effects

  • Vaginal irritation or burning sensation.
  • Increased vaginal discharge or change in consistency.
  • Mild itching or discomfort.
  • Transient odor change.
  • Local allergic reaction (redness, swelling).

Serious or Rare Side Effects

  • Systemic infection (rare in immunocompromised patients).
  • Severe allergic reaction or anaphylaxis.
  • Persistent or worsening irritation despite discontinuation.
  • Unexplained fever or pelvic pain.
  • Rare cases of opportunistic infection.

Precautions & Warnings

Before using Intigyne, consider the following safety measures.

  • Pregnancy: consult a healthcare provider before use.
  • Breastfeeding: discuss potential use with a physician.
  • Known allergy: avoid if hypersensitivity to Lactobacillus strains is documented.
  • Immunocompromised patients: use with caution and under medical supervision.
  • Concurrent intravaginal antibiotics: may reduce probiotic viability; coordinate timing with a clinician.
  • Store at ambient temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Intigyne may interact with certain intravaginal and systemic agents.

Major Interactions (Avoid)

  • Intravaginal antibiotics: can kill probiotic strains and diminish efficacy.
  • Antifungal vaginal treatments: may interfere with colonisation of beneficial lactobacilli.

Moderate Interactions (Monitor Closely)

  • Oral broad‑spectrum antibiotics: may alter gut flora but have limited impact on vaginal probiotic activity.
  • Hormonal contraceptives: no known direct interaction, but monitor for any changes in vaginal symptoms.
  • Vaginal douches or antiseptics: can disrupt probiotic colonisation.
  • Use of spermicidal gels: may affect bacterial balance; observe for irritation.

Frequently Asked Questions

Intigyne is a vaginal probiotic designed to help restore and maintain a healthy vaginal microbiota. It is commonly used after antibiotic treatment, to reduce recurrence of bacterial vaginosis, and to support the natural balance of flora in women experiencing recurrent vulvovaginal candidiasis.

The two Lactobacillus strains colonise the vaginal epithelium and produce lactic acid, hydrogen peroxide and bacteriocins. These substances lower the vaginal pH and create an environment that suppresses pathogenic bacteria and yeasts, thereby promoting a stable and protective microbial community.

The specific dosing regimen for Intigyne is determined by the prescribing healthcare professional based on the individual’s condition, age and treatment goals. Patients should follow the prescriber’s instructions and not alter the dose without medical advice.

Safety data for Intigyne in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential use with their obstetrician or healthcare provider to weigh any possible risks and benefits.

To order Intigyne, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials before providing pricing, availability, shipping details and import documentation.

Intigyne contains two well‑characterised strains, Lactobacillus gasseri DSM 14869 and Lactobacillus rhamnosus DSM 14870, which have documented ability to adhere to vaginal epithelium and produce antimicrobial metabolites. Compared with generic multi‑strain products, these strains are selected for their proven efficacy in clinical studies on bacterial vaginosis and yeast infection recurrence.

Intigyne should be stored at ambient temperature, ideally below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and avoid exposure to extreme heat or humidity to maintain bacterial viability.

Intigyne is administered intravaginally, typically as a capsule or tablet that is inserted into the vagina according to the prescriber’s instructions. The route allows direct delivery of the probiotic strains to the vaginal mucosa where they can colonise and exert their beneficial effects.

While rare, serious risks include systemic infection in immunocompromised individuals and severe allergic reactions such as anaphylaxis. Users should seek immediate medical attention if they experience fever, persistent pelvic pain, widespread rash, swelling of the face or throat, or any signs of a severe reaction.

Intigyne should be avoided by individuals with a known hypersensitivity to any Lactobacillus species, those who are severely immunocompromised without medical supervision, and anyone who has been advised by a healthcare professional not to use vaginal probiotics for specific medical reasons.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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