Product image of Intizol Vaginal (Metronidazole) supplied by GNH India

Intizol Vaginal

Active Ingredient:
Metronidazole
Origin:
EU

Intizol Vaginal (Metronidazole)

Metronidazole, the active ingredient in Intizol Vaginal, is a Nitroimidazole presented as a vaginal formulation for local use. It treats anaerobic bacterial and protozoal infections of the vagina in adult women.
GNH India supplies Intizol Vaginal as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Seid, S.A.

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Indications & Clinical Uses

Intizol Vaginal contains metronidazole, an antibiotic that targets anaerobic microorganisms responsible for common vaginal infections.

  • Bacterial vaginosis: reduces overgrowth of anaerobic bacteria and helps restore normal vaginal flora.
  • Trichomoniasis: eliminates the protozoan Trichomonas vaginalis, relieving symptoms and preventing recurrence.
  • Other vaginal infections: provides antimicrobial activity against susceptible anaerobic pathogens causing vaginitis.

How It Works

  • Metronidazole is taken up by anaerobic organisms and reduced to reactive nitro radicals. These radicals damage DNA and inhibit nucleic acid synthesis, leading to bacterial and protozoal cell death while sparing aerobic cells, which lack the necessary reduction pathways.

Side Effects

Intizol Vaginal may cause adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Vaginal irritation or burning: mild discomfort at the site of application.
  • Abnormal discharge: temporary changes in vaginal secretions.
  • Headache: occasional mild headache.
  • Nausea: transient feeling of nausea.
  • Metallic taste: occasional taste disturbance.
  • Itching: mild pruritus of the vulvar area.

Serious or Rare Side Effects

  • Allergic reaction: rash, swelling, or difficulty breathing.
  • Stevens‑Johnson syndrome: severe skin blistering and mucosal involvement.
  • Seizures: rare neurologic events.
  • Liver toxicity: elevated liver enzymes or hepatitis.
  • Severe nausea/vomiting: persistent gastrointestinal upset.
  • Hematologic changes: unexplained bruising or bleeding.

Precautions & Warnings

Intizol Vaginal should be used with caution and according to medical guidance.

  • Pregnancy: Category B, generally considered safe but use only if clearly needed.
  • Breastfeeding: Small amounts may be excreted in milk; consult a healthcare professional.
  • Alcohol: Avoid alcohol to prevent a disulfiram‑like reaction.
  • Duration: Do not exceed prescribed treatment length to reduce resistance risk.
  • Hypersensitivity: Discontinue if signs of allergic reaction appear.
  • Store at room temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Metronidazole can interact with several medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Alcohol: may cause severe flushing, nausea, and tachycardia.
  • Warfarin: increased anticoagulant effect, raising bleeding risk.
  • Lithium: heightened lithium toxicity.

Moderate Interactions (Monitor Closely)

  • Carbamazepine: may reduce metronidazole plasma levels.
  • Cimetidine: can increase metronidazole concentrations.
  • Rifampin: may decrease metronidazole effectiveness.

Frequently Asked Questions

Intizol Vaginal is a prescription medication that contains metronidazole, an antibiotic used to treat bacterial vaginosis, trichomoniasis, and other anaerobic vaginal infections in adult women. It works by eliminating the microorganisms that cause these conditions, helping to restore normal vaginal flora and relieve symptoms such as discharge, odor, and irritation.

Metronidazole enters anaerobic bacteria and protozoa and is reduced to reactive nitro radicals. These radicals damage the organism’s DNA and inhibit nucleic acid synthesis, leading to cell death. Aerobic cells lack the necessary reduction pathways, so the drug selectively targets the anaerobic pathogens responsible for vaginal infections.

The dosage and duration of Intizol Vaginal are determined by the prescribing healthcare professional based on the specific infection, severity, and patient factors. Patients should follow the prescriber’s instructions precisely and not alter the regimen without medical advice.

Intizol Vaginal is classified as Pregnancy Category B, indicating that animal studies have not shown risk and there are no well‑controlled studies in pregnant women. It is generally considered safe when clearly needed. Small amounts may be excreted in breast milk, so breastfeeding women should discuss use with their clinician.

To order Intizol Vaginal, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide. After the request, the sales team will verify trade or institutional credentials, then provide pricing, availability, shipping details (including any cold‑chain requirements), and import documentation.

The main alternatives for bacterial vaginosis and trichomoniasis include clindamycin and tinidazole. Metronidazole, the active ingredient in Intizol Vaginal, has a broad spectrum against anaerobic bacteria and protozoa, a well‑established safety profile, and is often preferred for its efficacy and lower cost. Clindamycin may be used when metronidazole intolerance occurs, while tinidazole offers a longer half‑life but can be more expensive.

Intizol Vaginal should be stored at room temperature, below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed when not in use to maintain stability.

Intizol Vaginal is applied intravaginally as directed by a healthcare professional. The medication is typically inserted into the vagina using the supplied applicator or a clean fingertip, following the prescribed schedule. Patients should wash their hands before and after administration and avoid sexual intercourse or tampon use for the period recommended by the prescriber.

Serious risks include severe allergic reactions such as rash, swelling, or breathing difficulties, and rare but life‑threatening conditions like Stevens‑Johnson syndrome or toxic epidermal necrolysis. Liver toxicity and neurologic effects such as seizures may also occur. Patients should seek immediate medical attention if they experience any of these symptoms.

Intizol Vaginal should not be used by individuals with a known hypersensitivity to metronidazole or any nitroimidazole compounds. It is also contraindicated in patients with severe liver disease or those who are currently consuming alcohol, due to the risk of a disulfiram‑like reaction. Pregnant or breastfeeding women should only use it when clearly indicated by a healthcare provider.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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