Product image of Intrafer (Ferric Hydroxide Polymaltose Complex) supplied by GNH India

Intrafer

Active Ingredient:
Ferric Hydroxide Polymaltose Complex
Origin:
EU

Intrafer (Ferric Hydroxide Polymaltose Complex)

Ferric hydroxide polymaltose complex, the active ingredient in Intrafer, is an iron supplement presented as an oral dosage form for oral use. It treats iron deficiency and iron deficiency anemia in adults and children who need to restore normal iron stores.
GNH India supplies Intrafer as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Pharmaday Pharmaceutical S.R.L. Unipersonale

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Indications & Clinical Uses

  • Intrafer, an iron supplement, is used to address conditions related to iron deficiency.
  • Iron deficiency anemia: helps restore hemoglobin levels and replenish depleted iron stores.
  • Iron deficiency: supports normal iron balance and prevents the development of anemia.

How It Works

  • Ferric hydroxide polymaltose complex delivers elemental iron in a polymer‑bound form that is released in the gastrointestinal tract. The iron is absorbed mainly in the duodenum, incorporated into hemoglobin and myoglobin, and stored as ferritin, thereby replenishing iron reserves and supporting oxygen transport.

Side Effects

Intrafer may cause a range of adverse reactions, most of which are mild and related to gastrointestinal irritation.

Common Side Effects

  • Nausea or upset stomach
  • Constipation or diarrhea
  • Abdominal discomfort or cramps
  • Darkened stools
  • Metallic taste in the mouth
  • Mild heartburn

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis)
  • Iron overload leading to organ damage
  • Severe constipation causing intestinal obstruction
  • Hypotension or dizziness
  • Severe skin rash or Stevens‑Johnson syndrome
  • Black or tarry stools indicating gastrointestinal bleeding

Precautions & Warnings

  • Before using Intrafer, consider the following safety measures.
  • Pregnancy and lactation: safety not established; use only if clearly needed.
  • Children: dosage must be individualized by a qualified healthcare professional.
  • Iron overload conditions: avoid use in patients with hemochromatosis or similar disorders.
  • Concurrent antacids or calcium supplements: may reduce iron absorption; separate dosing by at least two hours.
  • Monitor for signs of allergic reaction such as rash, swelling, or breathing difficulty.
  • Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Intrafer can interact with several medicines, affecting its absorption or efficacy.

Major Interactions (Avoid)

  • Oral iron chelators (e.g., deferoxamine): may markedly reduce iron availability.
  • Tetracycline or quinolone antibiotics: chelation can impair antibiotic absorption.
  • Levothyroxine (thyroid hormone replacement): concurrent use may diminish thyroid hormone uptake.

Moderate Interactions (Monitor Closely)

  • Antacids containing aluminum or magnesium: may decrease iron absorption.
  • Calcium supplements or dairy products: can interfere with iron uptake.
  • Foods high in phytates or polyphenols (e.g., tea, coffee, whole grains): may reduce iron absorption.

Frequently Asked Questions

Intrafer is an oral iron supplement indicated for the treatment of iron deficiency anemia and for correction of iron deficiency in individuals who need to restore normal iron stores. It is used under medical supervision to improve hemoglobin levels and prevent anemia‑related symptoms.

The complex delivers elemental iron in a polymer‑bound form that is released in the gastrointestinal tract. The iron is absorbed primarily in the duodenum, incorporated into hemoglobin and myoglobin, and stored as ferritin, thereby replenishing depleted iron reserves and supporting oxygen transport.

The dose of Intrafer is individualized by a healthcare professional based on the severity of iron deficiency, patient age, weight, and tolerance. The prescriber determines the appropriate amount and dosing schedule, which may be adjusted during therapy according to laboratory monitoring.

Safety data for ferric hydroxide polymaltose complex in pregnancy and lactation are limited. It should be used only when clearly needed and after a risk‑benefit assessment by a qualified clinician. Breastfeeding mothers should consult their physician before initiating therapy.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Intrafer’s ferric hydroxide polymaltose complex is a polymer‑bound iron formulation designed for gradual release, which may result in fewer gastrointestinal side effects compared with conventional ferrous salts. However, efficacy in raising hemoglobin is comparable, and choice of product depends on patient tolerance, cost, and clinical preference.

Intrafer should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and direct sunlight. Keep the container tightly closed and out of reach of children. Do not store in damp or excessively hot environments.

Intrafer is taken orally, usually with a glass of water. It can be taken with or without food, but to improve absorption it is often recommended to avoid concurrent intake of calcium‑rich foods, antacids or certain medications. Swallow tablets whole; do not crush or chew unless directed by a healthcare provider.

The most serious risks include severe allergic reactions such as anaphylaxis, iron overload leading to organ damage, and rare cases of severe constipation or intestinal obstruction. Patients should seek immediate medical attention if they experience symptoms like difficulty breathing, swelling, severe abdominal pain, or black stools.

Intrafer is contraindicated in individuals with known hypersensitivity to ferric hydroxide polymaltose complex or any excipients, and in patients with established iron overload disorders such as hemochromatosis. It should also be avoided in those receiving parenteral iron therapy unless specifically advised by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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