Product image of Intrafusin (Valine, Acetylcysteine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine) supplied by GNH India

Intrafusin

Active Ingredient:
Valine, Acetylcysteine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine
Origin:
EU

Intrafusin (Valine, Acetylcysteine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine)

Valine, Acetylcysteine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, the active ingredient in Intrafusin, is an amino acid supplement presented as an intravenous solution for infusion use. It is intended to support nutritional status in patients requiring parenteral amino acid provision.
GNH India supplies Intrafusin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Baxter Deutschland Gmbh

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Indications & Clinical Uses

Intrafusin is an intravenous amino acid supplement used to support metabolic and nutritional pathways in various clinical settings.

  • Protein‑energy malnutrition: helps restore nitrogen balance and lean body mass.
  • Post‑operative recovery: provides essential substrates for tissue repair and wound healing.
  • Critical illness: supplies indispensable amino acids to patients receiving parenteral nutrition.

How It Works

  • The amino acids in Intrafusin serve as fundamental building blocks for protein synthesis, stimulate mTOR signaling, and replenish intracellular pools required for cellular metabolism. They also act as precursors for neurotransmitters and antioxidants such as glutathione, thereby supporting metabolic homeostasis during periods of catabolic stress.

Side Effects

Intrafusin may be associated with a range of adverse reactions following intravenous administration.

Common Side Effects

  • Infusion site erythema or mild pain.
  • Transient nausea or mild gastrointestinal discomfort.
  • Headache or dizziness.
  • Mild hyperglycemia in susceptible individuals.
  • Temporary electrolyte shifts (e.g., mild potassium change).

Serious or Rare Side Effects

  • Anaphylactic or severe hypersensitivity reactions.
  • Hyperammonemia leading to altered mental status.
  • Metabolic acidosis or severe electrolyte imbalance.
  • Acute renal dysfunction or oliguria.
  • Thrombophlebitis at the infusion site.
  • Severe hypotension or cardiovascular instability.

Precautions & Warnings

When using Intrafusin, clinicians should observe several safety considerations.

  • Assess renal function: adjust or monitor use in patients with renal impairment.
  • Monitor blood glucose: amino acid infusion can affect glycemic control.
  • Check for hypersensitivity: discontinue immediately if allergic signs appear.
  • Avoid in severe hepatic failure: risk of ammonia accumulation.
  • Pregnancy and lactation: use only if potential benefits outweigh uncertain risks.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Intrafusin may interact with other therapies administered concurrently.

Major Interactions (Avoid)

  • High‑dose parenteral lipids: increased risk of hypertriglyceridemia.
  • Nephrotoxic agents: may exacerbate renal stress when combined.
  • Ammoniagenic drugs (e.g., valproate): heightened risk of hyperammonemia.

Moderate Interactions (Monitor Closely)

  • Insulin or oral hypoglycemics: monitor blood glucose levels.
  • Electrolyte‑containing solutions: watch for cumulative electrolyte disturbances.
  • Loop or thiazide diuretics: may affect fluid and electrolyte balance.

Frequently Asked Questions

Intrafusin is an intravenous amino acid formulation used to provide essential building blocks for protein synthesis in patients who cannot meet their nutritional needs orally. It is commonly employed in protein‑energy malnutrition, postoperative recovery, and critical‑illness settings where parenteral nutrition is indicated.

The blend supplies a spectrum of essential and conditionally essential amino acids that replenish intracellular pools, stimulate protein synthesis pathways such as mTOR, and serve as precursors for neurotransmitters and antioxidants. This supports tissue repair, immune function, and metabolic stability during catabolic stress.

Dosing of Intrafusin is individualized. The prescribing clinician determines the amount, infusion rate, and duration based on the patient’s weight, clinical condition, and overall nutritional plan. No fixed regimen is provided in public literature.

Safety data for Intrafusin in pregnancy and lactation are limited. It should only be used when the potential therapeutic benefit justifies any potential risk to the fetus or infant, and the decision should be made by the treating physician.

To request Intrafusin, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Intrafusin offers a comprehensive amino acid profile in a single intravenous bag, whereas some alternatives provide separate amino acid and dextrose solutions. This can simplify compounding and reduce preparation time, but clinicians must still tailor the overall nutrient composition to each patient’s metabolic needs.

Intrafusin must be stored refrigerated between 2 °C and 8 °C. Keep the container in its original packaging, protect it from light, and avoid freezing or vigorous shaking. Once removed from refrigeration, use the product within the time frame specified by the manufacturer.

Intrafusin is administered intravenously, typically via a controlled infusion pump. The infusion rate is set according to the prescribed dose and patient tolerance, and the solution is delivered through a sterile catheter or central line under aseptic conditions.

Serious risks include severe hypersensitivity reactions such as anaphylaxis, hyperammonemia, metabolic acidosis, acute renal dysfunction, and significant electrolyte disturbances. Prompt recognition and discontinuation of the infusion are essential if any of these events occur.

Intrafusin should be avoided in patients with known hypersensitivity to any of its amino acid components, in those with uncontrolled severe hepatic failure, and in individuals where the risk of hyperammonemia outweighs potential benefit. Clinical judgment is required for all contraindications.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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