Product image of Intralipid (Soya Oil, Purified) supplied by GNH India

Intralipid

Active Ingredient:
Soya Oil, Purified
Origin:
EU

Intralipid (Soya Oil, Purified)

Soya Oil, the active ingredient in Intralipid, is a intravenous lipid emulsion presented as an intravenous emulsion for intravenous use. It provides calories and essential fatty acids for patients requiring parenteral nutrition, helping to prevent essential fatty acid deficiency and support caloric needs when oral intake is not possible.

GNH India supplies Intralipid as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Fresenius Kabi Austria Gmbh

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Indications & Clinical Uses

Intralipid is used in clinical settings that require intravenous lipid supplementation for nutrition and metabolic support.

  • Parenteral nutrition: supplies calories and essential fatty acids to patients receiving total parenteral nutrition.
  • Essential fatty acid deficiency: corrects deficiency in patients unable to obtain adequate fatty acids orally.
  • Caloric supplementation in patients unable to eat orally: provides an energy source when oral intake is insufficient or contraindicated.

How It Works

  • Intralipid is a soybean‑oil based lipid emulsion that delivers triglycerides intravenously. The triglycerides are hydrolyzed by lipases to free fatty acids, which serve as an immediate energy source and provide essential fatty acids for membrane synthesis and cellular functions. The emulsion’s phospholipid coating stabilizes the particles, allowing safe infusion and distribution throughout the vascular system.

Side Effects

Intralipid may be associated with a range of infusion‑related reactions.

Common Side Effects

  • Hypertriglyceridemia: elevated serum triglyceride levels during therapy.
  • Fever or chills: transient temperature rise during infusion.
  • Infusion site reactions: erythema, pain, or swelling at the catheter site.
  • Thrombocytopenia: mild reduction in platelet count.
  • Lipemia of plasma: milky appearance of blood samples.

Serious or Rare Side Effects

  • Fat overload syndrome: severe metabolic disturbance from excessive lipid load.
  • Pulmonary embolism: rare embolic events related to lipid particles.
  • Anaphylactic reaction: severe allergic response, potentially life‑threatening.
  • Hepatic dysfunction: abnormal liver enzymes or steatosis with prolonged use.
  • Coagulopathy: impaired clotting due to dilutional effects.

Precautions & Warnings

When using Intralipid, clinicians should observe several safety measures.

  • Monitor triglyceride levels: check serum triglycerides regularly to avoid hypertriglyceridemia.
  • Assess liver function: adjust dosing in patients with hepatic impairment.
  • Use aseptic technique: prevent microbial contamination of the emulsion.
  • Evaluate for soy allergy: avoid in individuals with known hypersensitivity to soy components.
  • Adjust in sepsis: consider risk of fat overload in critically ill patients.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Intralipid can interact with other therapies that affect lipid metabolism or share infusion pathways.

Major Interactions (Avoid)

  • Concurrent lipid emulsions: cumulative fat load may precipitate fat overload syndrome.
  • Propofol infusion: both provide lipid calories, increasing risk of hypertriglyceridemia.
  • High‑dose heparin: may exacerbate triglyceride elevation.

Moderate Interactions (Monitor Closely)

  • Warfarin: lipid infusion can alter plasma protein binding, affecting anticoagulant levels.
  • Certain antibiotics (e.g., ceftriaxone): may precipitate when mixed with lipid emulsions.
  • Immunosuppressants (e.g., cyclosporine): monitor liver enzymes as both can affect hepatic metabolism.

Frequently Asked Questions

Intralipid is an intravenous lipid emulsion used to provide calories and essential fatty acids to patients who cannot receive nutrition orally. It is indicated for total parenteral nutrition, treatment of essential fatty acid deficiency, and caloric supplementation in critically ill or postoperative patients.

The purified soy oil in Intralipid supplies triglycerides that are hydrolyzed by lipases into free fatty acids after infusion. These fatty acids serve as an immediate energy source and supply essential fatty acids needed for cell membrane synthesis and various metabolic processes.

The dose of Intralipid is individualized by the prescribing clinician based on the patient’s caloric needs, weight, and clinical condition. Dosing calculations consider total energy requirements and the desired proportion of calories from lipids, and the prescriber determines the infusion rate and duration.

The safety of Intralipid in pregnancy and lactation has not been definitively established, and the pregnancy category is listed as unknown. Use should be considered only if the potential benefit justifies any potential risk to the fetus or infant, and it should be prescribed by a qualified healthcare professional.

To order Intralipid, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain handling if needed), and necessary import documentation.

Intralipid is a soybean‑oil based emulsion, offering a balanced profile of long‑chain triglycerides and essential fatty acids. Compared with newer mixed‑oil formulations, it may have a higher proportion of omega‑6 fatty acids, but it remains a widely used, well‑characterized option for delivering lipid calories in total parenteral nutrition.

Intralipid should be stored refrigerated at 2‑8 °C, protected from light, and must not be frozen or shaken. Before use, the emulsion should be inspected for any signs of separation, discoloration, or particulate matter, and the vial should be allowed to reach room temperature if required for infusion.

Intralipid is administered intravenously as an emulsion, typically via a central venous catheter. The infusion rate is set by the prescriber based on the patient’s caloric and lipid requirements, and the solution is infused over a period ranging from several hours to a full day, depending on the clinical protocol.

Serious risks include fat overload syndrome, which can lead to metabolic disturbances, pulmonary embolism from lipid particles, severe allergic (anaphylactic) reactions, and hepatic dysfunction with prolonged use. Monitoring triglyceride levels, liver function, and signs of allergic response is essential during therapy.

Intralipid should be avoided in patients with known hypersensitivity to soy or egg phospholipids, those with severe hypertriglyceridemia, uncontrolled sepsis, or in individuals at high risk for fat overload syndrome. Contraindications are determined by the treating physician based on the patient’s overall clinical status.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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