Product image of Intralipid (Soya Oil, Purified) supplied by GNH India

Intralipid

Active Ingredient:
Soya Oil, Purified
Origin:
EU

Intralipid (Soya Oil, Purified)

Soya Oil, the active ingredient in Intralipid, is a intravenous lipid emulsion presented as a sterile emulsion for intravenous use. It provides calories and essential fatty acids for patients receiving parenteral nutrition, including those who cannot tolerate enteral feeding.
GNH India supplies Intralipid as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Fresenius Kabi Ab

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Indications & Clinical Uses

Intralipid is used in the management of nutritional support and essential fatty acid deficiency in patients requiring parenteral feeding.

  • Parenteral nutrition in patients unable to receive enteral feeding: supplies calories and essential fatty acids to maintain energy balance.
  • Prevention of essential fatty acid deficiency: delivers linoleic and linolenic acids needed for cell membrane integrity.
  • Critical care caloric support: provides an immediate source of energy for critically ill patients on total parenteral nutrition.

How It Works

  • Intralipid delivers purified soy oil triglycerides encapsulated in a phospholipid emulsion. After intravenous infusion, lipoprotein lipase hydrolyzes the triglycerides to free fatty acids, which are taken up by tissues for ATP production, membrane synthesis, and as precursors for eicosanoids, thereby meeting caloric and essential fatty acid requirements.

Side Effects

Intralipid may be associated with a range of adverse reactions.

Common Side Effects

  • Hypertriglyceridemia: elevated serum triglyceride levels during therapy.
  • Fever or chills: transient temperature rise after infusion.
  • Nausea or vomiting: gastrointestinal discomfort.
  • Headache: mild to moderate intensity.
  • Injection site reactions: erythema or discomfort.

Serious or Rare Side Effects

  • Fat overload syndrome: severe metabolic disturbance from excessive lipid load.
  • Pancreatitis: inflammation of the pancreas related to high triglyceride levels.
  • Anaphylaxis or severe allergic reaction: rapid onset respiratory or cardiovascular compromise.
  • Pulmonary embolism: rare embolic events from lipid particles.
  • Hepatic dysfunction: abnormal liver enzymes or steatosis.

Precautions & Warnings

Prior to initiating Intralipid therapy, clinicians should consider several safety measures.

  • Monitor triglyceride levels: check serum triglycerides regularly to avoid hyperlipidemia.
  • Assess infection risk: avoid use in patients with uncontrolled sepsis.
  • Evaluate liver function: monitor hepatic enzymes during prolonged therapy.
  • Check for soy or egg phospholipid allergy: contraindicated in known hypersensitivity.
  • Use caution in pancreatitis history: consider alternative nutrition strategies.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Intralipid can interact with other medications and nutritional products, requiring careful management.

Major Interactions (Avoid)

  • Concurrent propofol infusion: combined lipid load may cause fat overload.
  • Co‑administration with other lipid‑containing parenterals: risk of cumulative hypertriglyceridemia.
  • Use with fibrates: may exacerbate triglyceride elevation.

Moderate Interactions (Monitor Closely)

  • Heparin therapy: may alter triglyceride metabolism.
  • Corticosteroids: can increase serum triglyceride concentrations.
  • Dextrose‑containing total parenteral nutrition: monitor glucose and lipid balance.

Frequently Asked Questions

Intralipid is an intravenous lipid emulsion used as part of parenteral nutrition to provide calories and essential fatty acids for patients who cannot receive enteral feeding, and to prevent or treat essential fatty acid deficiency.

The purified soy oil in Intralipid is composed of triglycerides that, after infusion, are hydrolyzed by lipoprotein lipase into free fatty acids. These fatty acids are then taken up by cells for energy production, membrane synthesis, and the generation of signaling molecules.

The dose of Intralipid is individualized by the prescribing clinician based on the patient’s caloric needs, lipid requirements, and laboratory parameters such as serum triglyceride levels. No standard dosing regimen is provided here.

Safety data for Intralipid in pregnancy and lactation are limited, and the product is classified as pregnancy category unknown. Use should be considered only if the potential benefit justifies any potential risk to the fetus or infant.

To order Intralipid, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain handling if needed), and import documentation.

Intralipid is a soy‑oil based emulsion, whereas some alternatives use fish oil or mixed lipid sources. Soy‑oil emulsions provide a high proportion of omega‑6 fatty acids, while fish‑oil formulations are richer in omega‑3s. Choice depends on clinical goals, patient tolerance, and specific fatty‑acid requirements.

Intralipid must be stored refrigerated at 2‑8 °C, protected from light, and should never be frozen or shaken. Before use, inspect the container for cracks or phase separation and allow the product to reach room temperature if required by the administration protocol.

Intralipid is administered intravenously, typically as an infusion added to a total parenteral nutrition bag or given as a separate lipid infusion. The infusion rate is set by the prescriber and monitored closely to avoid lipid overload.

Serious risks include fat overload syndrome, pancreatitis, severe allergic reactions such as anaphylaxis, pulmonary embolism, and hepatic dysfunction. Prompt recognition and management of these events are essential during therapy.

Intralipid should be avoided in patients with known hypersensitivity to soy or egg phospholipids, those with severe hypertriglyceridemia, uncontrolled sepsis, active pancreatitis, or in individuals for whom a lipid‑free nutrition regimen is indicated.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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