Product image of Intralipid (Soya Oil, Purified) supplied by GNH India

Intralipid

Active Ingredient:
Soya Oil, Purified
Origin:
EU

Intralipid (Soya Oil, Purified)

Soybean oil, the active ingredient in Intralipid, is a lipid emulsion presented as an emulsion for intravenous infusion use. It provides calories and essential fatty acids for patients who require parenteral nutrition and cannot receive enteral feeding, especially in critical care settings.

GNH India supplies Intralipid as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide through regulated supply chains that maintain product integrity and meet local regulatory requirements and provide reliable access to essential nutrition support.

Manufacturer / TM Owner

Fresenius Kabi Ab

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Indications & Clinical Uses

Intralipid is a lipid emulsion used in parenteral nutrition to supply calories and essential fatty acids.

  • Parenteral nutrition: Provides caloric and fatty‑acid support for patients who cannot be fed enterally.
  • Essential fatty acid deficiency prevention: Supplies linoleic and alpha‑linolenic acids to avoid deficiency during long‑term PN.
  • Critical care support: Delivers energy and membrane components for critically ill patients requiring intravenous nutrition.

How It Works

  • Intralipid delivers triglyceride‑rich soybean oil particles that are hydrolyzed by plasma lipoprotein lipase, releasing free fatty acids for cellular energy, membrane synthesis, and provision of essential fatty acids (linoleic and alpha‑linolenic acids) that the body cannot synthesize, thereby supporting metabolic needs during parenteral feeding.

Side Effects

Intralipid may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Hypertriglyceridemia: Elevated serum triglyceride levels.
  • Fever or chills during infusion.
  • Nausea or vomiting.
  • Infusion site erythema or pain.
  • Mild respiratory wheeze.
  • Transient hypotension.

Serious or Rare Side Effects

  • Fat overload syndrome: severe metabolic disturbance.
  • Anaphylactic or severe allergic reaction.
  • Pulmonary embolism from lipid droplets.
  • Thrombocytopenia or coagulopathy.
  • Hepatic dysfunction or cholestasis.
  • Severe metabolic acidosis.

Precautions & Warnings

Before initiating Intralipid therapy, clinicians should consider several safety measures.

  • Assess triglyceride levels: Monitor serum triglycerides before and during treatment.
  • Check for allergies: Avoid in patients with known soy or egg protein hypersensitivity.
  • Use aseptic technique: Ensure sterile handling to prevent infection.
  • Limit infusion rate: Follow recommended maximum rates to reduce fat overload risk.
  • Review lipid‑soluble drug interactions: Adjust concomitant therapies as needed.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Intralipid can affect the pharmacokinetics of several drugs and should be used with caution.

Major Interactions (Avoid)

  • Propofol: Combined lipid load may cause severe hypertriglyceridemia.
  • Corticosteroids: May increase serum triglyceride concentrations.
  • Heparin: Can potentiate lipolysis leading to low triglyceride levels.
  • Lipid‑soluble medications: May alter distribution and efficacy.

Moderate Interactions (Monitor Closely)

  • Warfarin: Lipid emulsion may affect INR monitoring.
  • Phenytoin: Protein binding may be altered, requiring level checks.
  • Cyclosporine: May increase risk of hyperlipidemia, necessitating lipid monitoring.

Frequently Asked Questions

Intralipid is an intravenous lipid emulsion used as part of parenteral nutrition. It supplies calories, essential fatty acids, and membrane components to patients who cannot receive enteral feeding, helping to prevent essential fatty acid deficiency and support metabolic needs during critical illness.

Soybean oil in Intralipid provides triglyceride particles that are broken down by lipoprotein lipase in the bloodstream. This releases free fatty acids, which serve as an energy source, contribute to cell‑membrane synthesis, and deliver essential fatty acids such as linoleic and alpha‑linolenic acids that the body cannot produce.

The dose of Intralipid is individualized. A prescribing clinician determines the volume and infusion rate based on the patient’s caloric requirements, lipid needs, serum triglyceride levels, and overall clinical condition. No fixed regimen is provided in public information.

The pregnancy category for Intralipid is listed as unknown. Use during pregnancy or lactation should be based on a careful risk‑benefit assessment by the treating physician, considering the nutritional needs of the mother and fetus or infant.

To order Intralipid, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain logistics if needed), and any required import documentation.

Intralipid is a soybean‑oil‑based emulsion, whereas alternatives such as ClinOleic or SMOFlipid contain mixtures of soybean, olive, fish, or medium‑chain triglycerides. These newer formulations aim to reduce inflammation and improve fatty‑acid profiles, but Intralipid remains widely used for its established efficacy, availability, and cost‑effectiveness.

Intralipid should be stored at 2‑8 °C, protected from light, and kept in its original container. Do not freeze or vigorously shake the emulsion, as this can damage the lipid particles and affect safety and efficacy.

Intralipid is given by intravenous infusion using aseptic technique. It is typically administered through a dedicated line or Y‑site with a controlled infusion pump, following the prescribed rate to avoid rapid lipid overload. Compatibility with other IV drugs should be checked before co‑administration.

The most serious risks include fat overload syndrome, severe hypertriglyceridemia, anaphylactic reactions, pulmonary embolism from lipid droplets, and hepatic dysfunction. Monitoring triglyceride levels, observing for allergic signs, and adhering to recommended infusion rates help mitigate these risks.

Intralipid is contraindicated in patients with known hypersensitivity to soy or egg proteins, severe hypertriglyceridemia, disorders of fat metabolism (e.g., lipoprotein lipase deficiency), and in those with acute pancreatitis related to high triglyceride levels. Clinicians should evaluate each case before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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