Product image of Intralipid (Soya Oil, Purified) supplied by GNH India

Intralipid

Active Ingredient:
Soya Oil, Purified
Origin:
EU

Intralipid (Soya Oil, Purified)

Soya Oil, the active ingredient in Intralipid, is an intravenous lipid emulsion presented as an intravenous emulsion for intravenous use. It supplies calories and essential fatty acids to patients receiving total parenteral nutrition, helping to prevent essential fatty acid deficiency and support metabolic needs.

GNH India supplies Intralipid as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide, ensuring quality and regulatory compliance across global markets.

Manufacturer / TM Owner

Fresenius Kabi Norge As

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Indications & Clinical Uses

  • Intralipid is used in parenteral nutrition to provide essential fatty acids and calories.
  • Parenteral nutrition: provides calories and essential fatty acids for patients unable to receive enteral feeding.
  • Essential fatty acid deficiency prevention: supplies linoleic acid to avoid deficiency during long‑term total parenteral nutrition.
  • Neonatal nutrition support: delivers needed lipids to premature infants requiring parenteral nutrition.

How It Works

  • Intralipid delivers lipid droplets composed primarily of triglycerides derived from purified soy oil. After intravenous infusion, lipoprotein lipase hydrolyzes the triglycerides into free fatty acids and glycerol, which are then taken up by tissues to supply energy and essential fatty acids required for cell membrane synthesis and metabolic processes.

Side Effects

Intralipid may cause a range of infusion‑related reactions.

Common Side Effects

  • Fever or chills during infusion
  • Mild hypertriglyceridemia
  • Fat overload syndrome (elevated serum lipids)
  • Transient rash or urticaria
  • Elevated liver enzymes
  • Electrolyte shifts (e.g., hypophosphatemia)

Serious or Rare Side Effects

  • Anaphylactic or severe hypersensitivity reaction
  • Severe hypertriglyceridemia leading to pancreatitis
  • Infection risk due to lipid medium supporting microbial growth
  • Pulmonary embolism from lipid particles
  • Metabolic acidosis in susceptible patients

Precautions & Warnings

  • When using Intralipid, clinicians should observe several safety measures.
  • Patient assessment: evaluate baseline triglyceride levels before initiation.
  • Monitoring: regularly check serum triglycerides, liver function tests, and electrolytes during therapy.
  • Compatibility: administer via a dedicated line; avoid mixing with incompatible solutions.
  • Infusion rate: do not exceed recommended rates to prevent fat overload syndrome.
  • Special populations: use caution in patients with disorders of lipid metabolism or severe hepatic impairment.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Intralipid can interact with other medications that affect lipid metabolism or increase the risk of hypertriglyceridemia.

Major Interactions (Avoid)

  • Propofol: additive lipid load may cause severe hypertriglyceridemia.
  • Heparin: can increase lipolysis and alter triglyceride levels.
  • High‑dose corticosteroids: may exacerbate hypertriglyceridemia.

Moderate Interactions (Monitor Closely)

  • Cyclosporine: may raise serum lipid concentrations.
  • Estrogen therapy: can increase triglyceride levels.
  • Other components of total parenteral nutrition: avoid exceeding total lipid calorie limits.

Frequently Asked Questions

Intralipid is an intravenous lipid emulsion used as part of total parenteral nutrition to supply calories and essential fatty acids to patients who cannot receive enteral feeding, and to prevent essential fatty acid deficiency during prolonged nutrition support.

The purified soy oil in Intralipid provides triglyceride‑rich lipid droplets. After infusion, lipoprotein lipase hydrolyzes these droplets into free fatty acids and glycerol, which are then utilized by cells for energy production, membrane synthesis, and other metabolic functions.

The dose of Intralipid is individualized and set by the prescribing clinician based on the patient’s caloric needs, body weight, and laboratory parameters. Dosing is calculated as a percentage of total parenteral nutrition calories and adjusted according to triglyceride levels.

The pregnancy safety category for Intralipid is unknown. It should only be used during pregnancy or lactation when the potential benefits to the mother outweigh any possible risks to the fetus or infant, and under close medical supervision.

To order Intralipid, submit an enquiry on the product page at gnhindia.com indicating the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and required import documentation.

Intralipid is a soy‑based lipid emulsion providing a balanced profile of essential fatty acids. Compared with fish‑oil or mixed‑oil emulsions, it has a lower proportion of omega‑3 fatty acids but is widely used due to its established safety record and compatibility with most parenteral nutrition regimens.

Intralipid must be stored refrigerated at 2‑8 °C, protected from light, and should never be frozen or shaken. Before use, allow the emulsion to reach room temperature and inspect for any signs of separation or discoloration.

Intralipid is administered intravenously, typically through a dedicated infusion line. It is added to the total parenteral nutrition bag or infused separately, following the prescribed infusion rate to avoid fat overload and monitor patient tolerance.

Serious risks include severe hypertriglyceridemia that can lead to pancreatitis, anaphylactic reactions, infection due to the lipid medium, and pulmonary embolism from lipid particles. Continuous monitoring of triglyceride levels and patient signs is essential.

Intralipid should be avoided in patients with known hypersensitivity to soy oil or any component of the emulsion, those with severe hypertriglyceridemia, uncontrolled lipid metabolism disorders, or in situations where a compatible lipid source is contraindicated.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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