Product image of Intralipid (Soya Oil, Purified) supplied by GNH India

Intralipid

Active Ingredient:
Soya Oil, Purified
Origin:
EU

Intralipid (Soya Oil, Purified)

Soya Oil, Purified, the active ingredient in Intralipid, is a intravenous lipid emulsion presented as an emulsion for intravenous infusion for patients requiring parenteral nutrition. It provides calories, essential fatty acids, and phospholipids when administered intravenously, supporting energy needs and cell membrane synthesis.\nGNH India supplies Intralipid as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Fresenius Kabi España S.A.U.

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Indications & Clinical Uses

  • Intralipid is used in clinical nutrition to deliver lipid calories and essential fatty acids for patients who cannot receive enteral feeding.\n\nParenteral nutrition: supplies calories and essential fatty acids for patients on total parenteral nutrition.\nEssential fatty acid deficiency: prevents and treats deficiency in long‑term lipid‑restricted diets.\nPatients unable to receive enteral feeding: provides necessary energy and membrane components when oral or tube feeding is not possible.

How It Works

  • Intralipid delivers purified soy oil triglycerides encapsulated in phospholipid micelles, which are hydrolyzed by lipases after intravenous infusion. The resulting free fatty acids and glycerol are taken up by tissues for oxidative energy production and incorporation into cellular membranes, while the phospholipids support membrane synthesis and transport of the lipid particles.

Side Effects

  • Intralipid may be associated with a range of adverse reactions following intravenous administration.\n\nCommon Side Effects:\n- Hypertriglyceridemia: elevated blood triglyceride levels.\n- Fever or chills: transient temperature rise during infusion.\n- Infusion site irritation: redness or discomfort at the catheter site.\n- Nausea or vomiting: gastrointestinal upset.\n- Lipemia: milky appearance of blood samples.\n- Respiratory distress: mild dyspnea during rapid infusion.\n\nSerious or Rare Side Effects:\n- Fat overload syndrome: severe metabolic disturbance from excess lipids.\n- Pancreatitis: inflammation of the pancreas due to high triglycerides.\n- Anaphylactic reaction: severe allergic response requiring emergency care.\n- Pulmonary embolism: lipid particles obstructing pulmonary vessels.\n- Hepatic dysfunction: liver enzyme elevations or steatosis.\n- Coagulopathy: bleeding abnormalities related to lipid interference with clotting factors.

Precautions & Warnings

  • When using Intralipid, clinicians should observe several safety measures to minimize risks.\n\nMonitor triglyceride levels: check serum triglycerides regularly during therapy.\nAssess for lipid intolerance: watch for signs of hypersensitivity or fat overload.\nUse caution in pancreatitis: avoid or limit use in patients with active pancreatic inflammation.\nAvoid in soy allergy: contraindicated for patients with known soy or soy oil hypersensitivity.\nAdjust in hepatic dysfunction: reduce dosage or monitor liver function tests closely.\nStore at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

  • Intralipid can interact with other medications, influencing efficacy or safety.\n\nMajor Interactions (Avoid):\n- Co‑administration with other lipid emulsions: may cause excessive lipid load.\n- Concurrent use with propofol: both are lipid‑based, increasing risk of fat overload syndrome.\n\nModerate Interactions (Monitor Closely):\n- Anticoagulants (e.g., warfarin): lipid infusion may alter INR levels.\n- Fibrates (e.g., gemfibrozil): combined effect may raise triglyceride concentrations.\n- High‑dose vitamin E: may affect coagulation parameters when given with lipid emulsions.

Frequently Asked Questions

Intralipid is an intravenous lipid emulsion used in parenteral nutrition to provide calories, essential fatty acids, and phospholipids for patients who cannot receive enteral feeding or who need prevention or treatment of essential fatty acid deficiency.

Soya Oil in Intralipid is delivered as triglyceride particles surrounded by phospholipid micelles. After infusion, lipases hydrolyze the triglycerides into free fatty acids and glycerol, which are then utilized by cells for energy production and membrane synthesis.

The dose of Intralipid is individualized by the prescribing clinician based on the patient’s caloric needs, lipid tolerance, and laboratory parameters such as triglyceride levels. No fixed regimen is provided here.

The safety of Intralipid in pregnancy or lactation has not been definitively established. Use should be considered only if the potential benefit justifies any potential risk, and decisions are made by the treating physician.

To order Intralipid, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where needed), and import documentation.

Intralipid is a soybean‑oil based lipid emulsion, offering a balanced profile of essential fatty acids. Compared with alternative emulsions that may use fish oil or medium‑chain triglycerides, Intralipid provides a traditional fatty acid composition suitable for most parenteral nutrition protocols, though specific clinical needs may guide the choice of formulation.

Intralipid should be stored at 2‑8 °C, kept refrigerated, protected from light, and must not be frozen or shaken. Before administration, the emulsion should be inspected for any signs of separation or discoloration.

Intralipid is administered intravenously as an emulsion, typically infused through a central or peripheral line under aseptic conditions. The infusion rate is set by the clinician according to the patient’s nutritional requirements and tolerance.

Serious risks include fat overload syndrome, pancreatitis, severe allergic reactions such as anaphylaxis, pulmonary embolism, and hepatic dysfunction. Patients should be monitored closely for signs of these complications during and after infusion.

Intralipid is contraindicated in patients with known hypersensitivity to soy or soy oil, those with severe lipid metabolism disorders, active pancreatitis, or uncontrolled hypertriglyceridemia. Clinicians should assess each patient’s medical history before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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