Product image of Intuniv (Guanfacine) supplied by GNH India

Intuniv

Active Ingredient:
Guanfacine
Origin:
EU

Intuniv (Guanfacine)

Guanfacine, the active ingredient in Intuniv, is an alpha‑2 adrenergic agonist presented as an extended‑release tablet for oral use. It is indicated for the treatment of attention deficit hyperactivity disorder (ADHD) in children and adolescents.
GNH India supplies Intuniv as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Takeda Pharmaceuticals International Ag Ireland Branch

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Indications & Clinical Uses

Intuniv is a non‑stimulant medication that targets the ADHD symptom pathway in pediatric patients.

  • Attention deficit hyperactivity disorder (ADHD) in children and adolescents: improves attention, reduces hyperactivity and impulsivity.

How It Works

  • Guanfacine selectively stimulates alpha‑2A adrenergic receptors in the prefrontal cortex, decreasing sympathetic outflow and enhancing neuronal signaling that supports attention and executive function. This modulation improves cortical regulation of behavior without stimulating dopamine release.

Side Effects

Intuniv may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Drowsiness: feeling unusually sleepy or fatigued.
  • Headache: mild to moderate cranial pain.
  • Dry mouth: reduced salivation leading to a dry sensation.
  • Stomach discomfort: nausea, abdominal pain or dyspepsia.
  • Dizziness: light‑headed feeling, especially when standing quickly.

Serious or Rare Side Effects

  • Low blood pressure: symptomatic hypotension, sometimes with fainting.
  • Slow heart rate: bradycardia that may require monitoring.
  • Depression or mood changes: emergence of depressive symptoms.
  • Liver enzyme elevation: abnormal liver function tests.
  • Allergic reactions: rash, itching, swelling or difficulty breathing.

Precautions & Warnings

Before initiating Intuniv, clinicians should evaluate several safety considerations.

  • Cardiovascular assessment: check blood pressure and heart rate baseline.
  • Concomitant medications: review other agents that affect blood pressure or heart rate.
  • History of depression: monitor mood changes during therapy.
  • Liver function: assess hepatic status if pre‑existing liver disease is present.
  • Pregnancy: category C; weigh potential benefits against risks.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Intuniv can interact with other drugs that influence cardiovascular or central nervous system function.

Major Interactions (Avoid)

  • CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may increase guanfacine levels.
  • Other antihypertensives: additive blood‑pressure‑lowering effect.

Moderate Interactions (Monitor Closely):\n- CNS depressants (e.g., benzodiazepines, alcohol): may enhance sedation.

  • Stimulant ADHD medications: may counteract blood‑pressure effects.
  • Antidepressants (e.g., tricyclics): potential for additive hypotensive effects.

Frequently Asked Questions

Intuniv is prescribed to manage attention deficit hyperactivity disorder (ADHD) in children and adolescents. It helps improve focus, reduce hyperactivity, and control impulsive behavior without using stimulant agents.

Guanfacine selectively activates alpha‑2A adrenergic receptors in the prefrontal cortex, lowering sympathetic outflow and strengthening neural pathways that support attention and executive function, thereby alleviating ADHD symptoms.

The dosage of Intuniv is individualized. A prescriber determines the appropriate starting dose and any subsequent adjustments based on the patient’s age, response, and tolerability.

Intuniv is classified as pregnancy category C, indicating that risk cannot be ruled out. It should be used only if the potential benefit justifies the potential risk to the fetus. Breastfeeding mothers should consult their physician, as guanfacine may pass into breast milk.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Unlike stimulant agents that increase dopamine and norepinephrine release, Intuniv is a non‑stimulant that modulates alpha‑2A receptors to improve prefrontal cortical function. It may be preferred when stimulants are contraindicated, cause intolerable side effects, or when a smoother symptom control is desired.

Intuniv tablets should be stored at ambient temperature, below 25 °C, in their original packaging. Protect them from moisture, excessive heat and direct sunlight to maintain product stability.

Intuniv is taken orally as an extended‑release tablet, usually once daily in the morning. The tablet should be swallowed whole with water and not crushed, chewed, or divided.

Serious risks include symptomatic hypotension, bradycardia, and rare cases of severe depression or liver enzyme elevations. Patients should be monitored for low blood pressure, slow heart rate, mood changes, and any signs of allergic reaction.

Intuniv is contraindicated in patients with known hypersensitivity to guanfacine or any tablet excipients, and in those with severe cardiovascular disorders such as uncontrolled hypotension or bradycardia. Caution is also advised for individuals with significant liver impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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