Product image of Intuniv (Guanfacine) supplied by GNH India

Intuniv

Active Ingredient:
Guanfacine
Origin:
EU

Intuniv (Guanfacine)

Guanfacine, the active ingredient in Intuniv, is a Alpha-2A adrenergic agonist presented as an extended-release tablet for oral use. It treats attention deficit hyperactivity disorder in children and adolescents and hypertension in adults.

GNH India supplies Intuniv as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Takeda Pharmaceuticals International Ag Ireland Branch

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Indications & Clinical Uses

Intuniv acts on central adrenergic pathways to manage neurobehavioral and cardiovascular conditions.

  • Attention deficit hyperactivity disorder (ADHD): improves attention, reduces hyperactivity and impulsivity in pediatric patients.
  • Hypertension: lowers systolic and diastolic blood pressure in adult patients.

How It Works

  • Guanfacine selectively stimulates alpha-2A adrenergic receptors in the brain, decreasing sympathetic outflow and reducing norepinephrine release. This modulation enhances prefrontal cortex function, improving attention and impulse control, while also producing vasodilatory effects that lower peripheral vascular resistance and blood pressure.

Side Effects

Intuniv may cause a range of adverse reactions. Patients should be aware of both common and serious possibilities.

Common Side Effects

  • Dizziness
  • Fatigue
  • Dry mouth
  • Headache
  • Insomnia
  • Nausea

Serious or Rare Side Effects

  • Hypotension
  • Bradycardia
  • Syncope
  • Depression or suicidal thoughts
  • Severe allergic reactions
  • Cardiac arrhythmias

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety aspects.

  • Blood pressure monitoring: assess baseline and periodically during treatment.
  • Cardiac function: evaluate heart rate and ECG in patients with known cardiac disease.
  • Dose adjustments: use caution in hepatic impairment.
  • Concomitant CNS depressants: monitor for additive sedation.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Guanfacine can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • CYP3A4 inhibitors: may increase guanfacine plasma concentrations.
  • Other antihypertensives: additive hypotensive effect.
  • Clonidine: risk of severe hypotension when combined.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers: may reduce guanfacine levels.
  • Sedatives: increased drowsiness.
  • Alcohol: enhanced central nervous system depression.

Frequently Asked Questions

Intuniv is prescribed for attention deficit hyperactivity disorder (ADHD) to improve focus and reduce hyperactivity, and for hypertension to lower blood pressure in adult patients.

Guanfacine selectively activates alpha-2A adrenergic receptors in the brain, reducing sympathetic nerve activity and enhancing prefrontal cortex function, which helps control attention and impulse regulation while also causing vasodilation to lower blood pressure.

The appropriate dose of Intuniv is determined by the prescribing clinician based on the patient’s age, condition, and response to therapy. Dosage adjustments are made according to clinical guidelines.

Safety data for guanfacine in pregnancy and lactation are limited. Healthcare providers should weigh potential benefits against risks and consider alternative treatments when possible.

To request Intuniv, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, confirming trade or institutional credentials before providing pricing, availability, shipping details, and import documentation.

Intuniv (guanfacine) is a non‑stimulant that targets alpha‑2A receptors, offering an alternative for patients who cannot tolerate stimulants or need adjunct therapy. Its mechanism differs from dopamine‑reuptake inhibitors, providing a distinct side‑effect profile.

Intuniv tablets should be stored at room temperature, below 25 °C, in the original packaging, protected from moisture and light to maintain stability.

Intuniv is taken orally as an extended‑release tablet, usually once daily in the morning or as directed by a healthcare professional.

Serious risks include severe hypotension, bradycardia, syncope, depression, suicidal thoughts, and rare allergic reactions. Patients should be monitored for these events, especially during dose changes.

Intuniv is contraindicated in patients with known hypersensitivity to guanfacine or any tablet components, and should be used with caution in individuals with severe cardiac conduction disorders, low blood pressure, or hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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