Product image of Intuniv (Guanfacine) supplied by GNH India

Intuniv

Active Ingredient:
Guanfacine
Origin:
EU

Intuniv (Guanfacine)

Guanfacine, the active ingredient in Intuniv, is an alpha‑2 adrenergic agonist presented as an extended‑release tablet for oral use. It belongs to the central antihypertensive class and works by reducing sympathetic outflow from the central nervous system, thereby treating attention deficit hyperactivity disorder in children and adolescents and is also employed off‑label for hypertension.

GNH India supplies Intuniv as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, adhering to EU quality standards and providing reliable global distribution.

Manufacturer / TM Owner

Takeda Pharmaceuticals International Ag Ireland Branch

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Indications & Clinical Uses

Intuniv (guanfacine) is an alpha‑2A adrenergic receptor agonist used primarily in the management of neurodevelopmental and cardiovascular conditions.

  • Attention deficit hyperactivity disorder (ADHD): improves attention, reduces hyperactivity and impulsivity in children and adolescents.
  • Hypertension (off‑label): lowers blood pressure by decreasing sympathetic nervous system activity.
  • Tourette syndrome (off‑label): may reduce the frequency and severity of motor and vocal tics.

How It Works

  • Guanfacine selectively stimulates alpha‑2A adrenergic receptors in the brainstem, which inhibits the release of norepinephrine and reduces sympathetic outflow from the central nervous system. This modulation leads to decreased peripheral vascular resistance and central nervous system effects that improve attention and behavioral control in ADHD.

Side Effects

Intuniv may cause a range of adverse reactions, most of which are mild to moderate in severity.

Common Side Effects

  • Drowsiness
  • Fatigue
  • Headache
  • Dry mouth

Serious or Rare Side Effects

  • Bradycardia
  • Severe hypotension
  • Syncope

Precautions & Warnings

Before initiating therapy with Intuniv, consider the following precautions:

  • Monitor blood pressure and heart rate: assess baseline values and follow up regularly.
  • Adjust dose gradually: titrate to the lowest effective dose to minimize adverse effects.
  • Use caution in patients with cardiac disease: evaluate for conduction abnormalities.
  • Avoid abrupt discontinuation: taper the dose to prevent rebound hypertension.
  • Use with caution in hepatic impairment: dose may need adjustment.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Intuniv can interact with several medications, requiring attention to avoid adverse outcomes. Major Interactions (Avoid):\n- CYP3A4 inhibitors: may increase guanfacine plasma concentrations.

  • CYP3A4 inducers: may reduce guanfacine effectiveness.
  • Clonidine: additive hypotensive effects.

Moderate Interactions (Monitor Closely)

  • CNS depressants (e.g., benzodiazepines): may enhance sedation.
  • Selective serotonin reuptake inhibitors (SSRIs): may increase risk of dizziness.

Frequently Asked Questions

Intuniv is prescribed primarily for the treatment of attention deficit hyperactivity disorder (ADHD) in children and adolescents. It may also be used off‑label to manage hypertension by reducing sympathetic nervous system activity.

Guanfacine selectively activates alpha‑2A adrenergic receptors in the brainstem, which decreases the release of norepinephrine. This reduces sympathetic outflow, leading to lower blood pressure and improved attention and behavioral control in ADHD.

The appropriate dose of Intuniv is determined individually by a qualified prescriber based on the patient’s age, weight, clinical response, and tolerability. Dosage adjustments are made gradually to achieve the desired therapeutic effect.

Intuniv is classified as Pregnancy Category B, indicating that animal studies have not shown risk but there are no well‑controlled studies in pregnant women. It should be used during pregnancy only if clearly needed, and breastfeeding mothers should consult their physician.

To place an order, submit an enquiry on the Intuniv product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and import documentation.

Intuniv belongs to the alpha‑2 adrenergic agonist class, whereas many other ADHD drugs are stimulants such as methylphenidate. Intuniv is non‑stimulant, which may be preferred for patients who cannot tolerate stimulants or have comorbid conditions like anxiety.

Intuniv tablets should be stored at ambient temperature, below 25 °C, in the original container to protect them from moisture and light. Keep the medication out of reach of children and do not use after the expiration date.

Intuniv is taken orally as an extended‑release tablet, usually once daily in the morning or evening as directed by the prescriber. The tablet should be swallowed whole with water and not crushed or chewed.

Serious risks include significant bradycardia, severe hypotension, and syncope. Patients should be monitored for these events, especially during dose titration or if they have underlying cardiac conditions.

Intuniv is contraindicated in patients with known hypersensitivity to guanfacine or any tablet components. Caution is advised for individuals with severe cardiac conduction disorders, uncontrolled hypertension, or those taking interacting medications without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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