Product image of Intuniv (Guanfacine) supplied by GNH India

Intuniv

Active Ingredient:
Guanfacine
Origin:
EU

Intuniv (Guanfacine)

Guanfacine, the active ingredient in Intuniv, is a Alpha-2A adrenergic agonist presented as a extended-release tablet for oral use. It treats attention deficit hyperactivity disorder (ADHD) and hypertension in children, adolescents, and adults.

GNH India supplies Intuniv as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Takeda Pharmaceuticals International Ag Ireland Branch

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Indications & Clinical Uses

Intuniv (guanfacine) is used in conditions involving central nervous system regulation and vascular tone.

  • Attention deficit hyperactivity disorder (ADHD): improves attention, reduces hyperactivity and impulsivity.
  • Hypertension: lowers blood pressure by decreasing sympathetic outflow.

How It Works

  • Guanfacine selectively stimulates alpha-2A adrenergic receptors in the brainstem, which reduces norepinephrine release and diminishes sympathetic nervous system activity. This leads to decreased peripheral vascular resistance and enhanced prefrontal cortical function, supporting better attention and impulse control while also lowering blood pressure.

Side Effects

Common side effects are generally mild and may resolve with continued therapy.

Common Side Effects

  • Drowsiness
  • Dry mouth
  • Fatigue
  • Headache
  • Dizziness
  • Nausea

Serious or Rare Side Effects

  • Severe hypotension
  • Bradycardia
  • Syncope
  • Heart block
  • Liver function abnormalities
  • Allergic reactions such as rash or angioedema

Precautions & Warnings

Intuniv should be used with careful monitoring and appropriate patient counseling.

  • Monitor blood pressure: check regularly during initiation and dose adjustments.
  • Assess heart rate: watch for bradycardia, especially in patients with cardiac history.
  • Avoid abrupt discontinuation: taper under medical supervision to prevent rebound hypertension.
  • Caution in hepatic impairment: dose may need adjustment due to altered metabolism.
  • Avoid concomitant use with strong CYP3A4 inhibitors: may increase guanfacine exposure.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Intuniv may interact with several drug classes, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may cause excessive guanfacine levels.
  • Antihypertensive agents (e.g., clonidine, beta‑blockers): additive hypotensive effect.
  • Sedatives (e.g., benzodiazepines): increased central nervous system depression.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampin): may reduce therapeutic effectiveness.
  • Antidepressants (e.g., SSRIs): may alter blood pressure response.
  • Diuretics: may enhance hypotensive effect.

Frequently Asked Questions

Intuniv is prescribed for attention deficit hyperactivity disorder (ADHD) to improve focus and reduce impulsivity, and for hypertension to lower elevated blood pressure by reducing sympathetic nervous system activity.

Guanfacine selectively activates alpha-2A adrenergic receptors in the brainstem, decreasing norepinephrine release. This reduces sympathetic outflow, leading to lower blood pressure and enhanced prefrontal cortical function, which supports attention and impulse control.

The appropriate dose of Intuniv is determined by a qualified prescriber based on the patient’s age, condition, and response. Dosage adjustments are made under medical supervision to achieve the desired therapeutic effect.

Safety data for guanfacine in pregnancy and lactation are limited. The drug should only be used if the potential benefit justifies any potential risk to the fetus or infant, and this decision must be made by a healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Intuniv (guanfacine) is a non‑stimulant option that targets alpha-2A receptors, whereas many other ADHD drugs are stimulants that increase dopamine and norepinephrine levels. Intuniv may be preferred when stimulant side effects are problematic or when a patient requires a different mechanism of action.

Intuniv tablets should be stored at ambient temperature, below 25 °C, in the original container to protect them from moisture and light. Keep the medication out of reach of children.

Intuniv is taken orally as an extended‑release tablet, usually once daily in the morning or as directed by a healthcare provider. The tablet should be swallowed whole with water and not crushed or chewed.

Serious risks include severe hypotension, bradycardia, syncope, heart block, liver function abnormalities, and rare allergic reactions such as rash or angioedema. Patients should be monitored regularly for these events, especially during dose changes.

Intuniv is contraindicated in patients with known hypersensitivity to guanfacine or any tablet components, and it should be used with caution in individuals with severe cardiac conduction disorders, uncontrolled hypertension, or significant liver impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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