Product image of Inuvair (Formoterol Fumarate Dihydrate, Beclometasone Dipropionate Anhydrous) supplied by GNH India

Inuvair

Active Ingredient:
Formoterol Fumarate Dihydrate, Beclometasone Dipropionate Anhydrous
Origin:
EU

Inuvair (Formoterol Fumarate Dihydrate, Beclometasone Dipropionate Anhydrous)

Formoterol fumarate dihydrate / beclometasone dipropionate anhydrous, the active ingredient in Inuvair, is a LABA/ICS combination presented as an inhaler for inhalation use. It provides maintenance therapy for asthma and chronic obstructive pulmonary disease in adults.

GNH India supplies Inuvair as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Chiesi Gmbh

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Indications & Clinical Uses

Inuvair is a fixed‑dose inhaled combination that targets airway obstruction and inflammation in chronic respiratory disease.

  • Asthma: improves symptom control and reduces the frequency of exacerbations.
  • Chronic obstructive pulmonary disease (COPD): enhances lung function and lowers the risk of COPD flare‑ups.
  • Maintenance therapy: provides long‑term bronchodilation and anti‑inflammatory effect for patients requiring daily inhaled treatment.

How It Works

  • Formoterol acts as a long‑acting β2‑adrenergic agonist, binding to β2 receptors on airway smooth muscle and causing relaxation, while beclometasone is an inhaled glucocorticoid that binds glucocorticoid receptors, modulating gene transcription to suppress inflammatory cytokines and reduce airway edema. The combined action yields sustained bronchodilation together with anti‑inflammatory protection.

Side Effects

Adverse reactions may occur with inhaled therapy and should be monitored.

Common Side Effects

  • Throat irritation or soreness.
  • Cough or wheeze after inhalation.
  • Hoarseness or voice changes.
  • Oral candidiasis (thrush).
  • Headache.
  • Tremor or shakiness.

Serious or Rare Side Effects

  • Paradoxical bronchospasm.
  • Severe allergic reaction (anaphylaxis).
  • Cardiac arrhythmia or palpitations.
  • Pneumonia, especially in COPD patients.
  • Adrenal suppression with high‑dose or prolonged use.
  • Reduced bone mineral density with chronic exposure.

Precautions & Warnings

Before prescribing Inuvair, clinicians should consider several safety aspects.

  • Assess disease control: confirm that the patient requires combination therapy.
  • Monitor for oral thrush: advise rinsing mouth after each inhalation.
  • Use a spacer device: helps reduce oropharyngeal deposition.
  • Avoid abrupt discontinuation: taper if long‑term use is planned.
  • Evaluate cardiovascular risk: caution in patients with arrhythmias or hypertension.
  • Store at room temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Inhaled corticosteroid/LABA combinations can interact with other medicines that affect the respiratory or cardiovascular systems.

Major Interactions (Avoid)

  • Non‑selective beta‑blockers: may blunt bronchodilator effect.
  • Potent CYP3A4 inhibitors (e.g., ketoconazole): can increase systemic exposure to beclometasone.
  • Monoamine oxidase inhibitors (MAOIs): may enhance sympathomimetic activity.

Moderate Interactions (Monitor Closely)

  • Diuretics: may exacerbate hypokalaemia when combined with β2‑agonists.
  • Theophylline: additive bronchodilator effect may increase side‑effects.
  • Other inhaled corticosteroids: risk of systemic glucocorticoid effects.
  • Sympathomimetic agents (e.g., epinephrine): may increase cardiovascular stimulation.

Frequently Asked Questions

Inuvair is prescribed as a maintenance inhaler for adults with asthma and chronic obstructive pulmonary disease (COPD). It helps control symptoms, improve lung function, and reduce the frequency of disease‑related exacerbations when used regularly as part of a long‑term treatment plan.

Formoterol, a long‑acting β2‑adrenergic agonist, relaxes airway smooth muscle by stimulating β2 receptors, providing sustained bronchodilation. Beclometasone, an inhaled glucocorticoid, binds glucocorticoid receptors to suppress inflammatory gene expression, decreasing airway swelling and mucus production. Together they deliver both bronchodilatory and anti‑inflammatory effects.

The specific dose and inhalation schedule for Inuvair are determined by the prescribing clinician based on the patient’s severity of asthma or COPD, age, and response to therapy. Patients should follow the exact instructions provided on the prescription label and by their healthcare professional.

Safety data for Inuvair in pregnancy and lactation are limited. The product should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss risks and alternatives with their healthcare provider.

To request Inuvair, visit the product page on gnhindia.com, enter the required quantity, and submit the enquiry form. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Inuvair combines a long‑acting β2‑agonist (formoterol) with an inhaled corticosteroid (beclometasone) in a single device, offering both bronchodilation and anti‑inflammatory action. Compared with single‑component inhalers, this fixed‑dose combination can simplify regimens, improve adherence, and provide consistent dosing, though choice of therapy should be individualized by the prescriber.

Store Inuvair at room temperature, below 25 °C (77 °F). Keep the inhaler in its original packaging, protect it from moisture and direct sunlight, and avoid exposing it to extreme temperatures that could affect the stability of the active ingredients.

Inuvair is delivered via inhalation using a metered‑dose inhaler. Patients should prime the device according to the manufacturer’s instructions, exhale fully, place the mouthpiece in the mouth, and inhale slowly and deeply while actuating the inhaler. A spacer may be used to improve drug deposition and reduce oropharyngeal exposure.

Serious adverse events, although rare, include paradoxical bronchospasm, severe allergic reactions such as anaphylaxis, cardiac arrhythmias, pneumonia (particularly in COPD), and systemic effects of corticosteroids like adrenal suppression or reduced bone density with prolonged high‑dose use. Patients should seek immediate medical attention if any of these occur.

Inuvair is contraindicated in patients with a known hypersensitivity to formoterol, beclometasone, or any component of the inhaler. It should also be avoided in individuals who have experienced a severe allergic reaction to other inhaled corticosteroids or β2‑agonists. Clinicians must assess each patient’s medical history before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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