Product image of Inuvair (Formoterol Fumarate Dihydrate, Beclometasone Dipropionate Anhydrous) supplied by GNH India

Inuvair

Active Ingredient:
Formoterol Fumarate Dihydrate, Beclometasone Dipropionate Anhydrous
Origin:
EU

Inuvair (Formoterol Fumarate Dihydrate, Beclometasone Dipropionate Anhydrous)

Beclometasone dipropionate / Formoterol fumarate, the active ingredient in Inuvair, is an inhaled corticosteroid / long‑acting β2‑agonist combination presented as an inhalation aerosol (metered‑dose inhaler) for inhalation use. It provides maintenance therapy for asthma and chronic obstructive pulmonary disease in adult patients.

GNH India supplies Inuvair as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. Its company adheres to stringent quality standards and provides regulatory‑approved products to health‑care institutions across multiple continents. Its distribution network ensures reliable delivery and post‑market support for respiratory therapies.

Manufacturer / TM Owner

Chiesi Hellas S.A.

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Indications & Clinical Uses

Inuvair combines an inhaled corticosteroid with a long‑acting β2‑agonist, targeting the inflammatory and bronchoconstrictive components of chronic airway diseases.

  • Asthma: reduces airway inflammation and improves bronchodilation to help prevent symptoms and exacerbations.
  • Chronic obstructive pulmonary disease (COPD): provides long‑acting bronchodilation and anti‑inflammatory action to maintain lung function and reduce flare‑ups.
  • Exercise‑induced bronchoconstriction: may be incorporated into a maintenance regimen to control symptoms during physical activity.

How It Works

  • Beclometasone dipropionate binds to intracellular glucocorticoid receptors, modulating gene transcription to suppress airway inflammation, cytokine production, and immune cell activation. Formoterol fumarate selectively stimulates β2‑adrenergic receptors on airway smooth muscle, increasing cyclic AMP levels, which leads to prolonged bronchodilation. The complementary actions of anti‑inflammatory and bronchodilatory effects provide sustained control of airway narrowing in asthma and COPD.

Side Effects

Inhaled corticosteroid/long‑acting β2‑agonist combinations can be associated with a range of adverse reactions.

Common Side Effects

  • Throat irritation or soreness
  • Hoarseness or voice changes
  • Oral candidiasis (thrush)
  • Cough or wheezing after inhalation
  • Headache
  • Tremor

Serious or Rare Side Effects

  • Paradoxical bronchospasm
  • Adrenal suppression with long‑term high‑dose use
  • Pneumonia, especially in COPD patients
  • Cardiac arrhythmias or tachycardia
  • Severe allergic reactions (anaphylaxis)
  • Hyperglycemia or worsening diabetes control

Precautions & Warnings

When prescribing Inuvair, clinicians should consider several safety measures to minimize risk.

  • Monitor for oral thrush: advise rinsing mouth after each inhalation.
  • Use with caution in patients with cardiovascular disease: assess heart rate and blood pressure.
  • Assess adrenal function during prolonged high‑dose therapy.
  • Avoid abrupt discontinuation: taper dose to prevent loss of control.
  • Use the lowest effective dose to achieve symptom control.
  • Store at room temperature: keep in the original pack, protect from moisture and heat.

Avoid Interactions

Inuvair may interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Non‑selective β‑blockers: may reduce bronchodilator effect and precipitate bronchospasm.
  • Concurrent use of other inhaled corticosteroids: increases risk of systemic corticosteroid effects.
  • Monoamine oxidase inhibitors (MAOIs) combined with high‑dose β2‑agonists: risk of severe hypertension.

Moderate Interactions (Monitor Closely)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase systemic exposure to beclometasone.
  • Diuretics (especially loop diuretics): may potentiate hypokalemia from β2‑agonist activity.
  • Sympathomimetic drugs (e.g., pseudoephedrine): may enhance cardiovascular effects.

Frequently Asked Questions

Inuvair is a prescription inhaler that provides maintenance therapy for asthma and chronic obstructive pulmonary disease (COPD). It combines an anti‑inflammatory corticosteroid with a long‑acting bronchodilator to help control symptoms, reduce exacerbations, and improve lung function in adult patients.

Beclometasone dipropionate binds to glucocorticoid receptors inside airway cells, altering gene expression to suppress inflammatory mediators, reduce swelling, and limit immune‑cell activity. This anti‑inflammatory action helps keep the airways less reactive and less prone to narrowing.

Formoterol fumarate selectively activates β2‑adrenergic receptors on airway smooth‑muscle cells, increasing cyclic AMP levels. The rise in cAMP leads to relaxation of the muscle, producing a long‑lasting bronchodilatory effect that helps keep the airways open for up to 12 hours.

The prescribed dose of Inuvair is individualized by the treating physician based on disease severity, patient response, and clinical guidelines. The prescriber determines the number of inhalations per day and the total daily dose, which may be adjusted over time.

Safety data for Inuvair in pregnancy and lactation are limited. The decision to use the product should be made by a healthcare professional after weighing potential benefits against possible risks to the fetus or infant. Women who are pregnant or nursing should discuss their treatment options with their doctor.

To order Inuvair, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Inuvair contains beclometasone dipropionate and formoterol fumarate, a pairing that offers potent anti‑inflammatory activity together with a rapid‑onset, long‑duration bronchodilator. Compared with alternatives such as budesonide/formoterol or fluticasone/salmeterol, Inuvair provides a similar efficacy profile, but the specific corticosteroid potency and pharmacokinetic properties may differ, influencing dosing frequency and side‑effect risk.

Inuvair should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and direct sunlight. Keep the inhaler upright, avoid exposing it to extreme temperatures, and replace the device after the indicated number of doses or when the dose counter reaches zero.

Inuvair is delivered via a metered‑dose inhaler. The patient should shake the inhaler, exhale fully, place the mouthpiece in the mouth, and inhale slowly and deeply while actuating the device. After each inhalation, the mouth should be rinsed with water to reduce the risk of oral thrush.

Serious risks include paradoxical bronchospasm, adrenal suppression with prolonged high‑dose use, pneumonia (particularly in COPD patients), cardiac arrhythmias or tachycardia, severe allergic reactions such as anaphylaxis, and significant hyperglycemia in diabetic patients. Any of these symptoms require immediate medical attention.

Inuvair is contraindicated in patients with known hypersensitivity to beclometasone, formoterol, or any excipients in the inhaler. It should also be avoided in individuals who have experienced a severe allergic reaction to other inhaled corticosteroid/LABA products. Patients with uncontrolled cardiovascular disease should use it only under close medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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