Product image of Inuvair (Formoterol Fumarate Dihydrate, Beclometasone Dipropionate Anhydrous) supplied by GNH India

Inuvair

Active Ingredient:
Formoterol Fumarate Dihydrate, Beclometasone Dipropionate Anhydrous
Origin:
EU

Inuvair (Formoterol Fumarate Dihydrate, Beclometasone Dipropionate Anhydrous)

Beclometasone dipropionate and Formoterol fumarate, the active ingredients in Inuvair, are an inhaled corticosteroid/long‑acting β2‑agonist combination presented as a fixed‑dose inhalation spray for inhalation use. The product provides anti‑inflammatory and bronchodilator effects for the maintenance treatment of asthma and chronic obstructive pulmonary disease in adults and adolescents.

GNH India supplies Inuvair as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with a focus on quality assurance and regulatory compliance. The company provides reliable logistics and supports import documentation for global markets.

Manufacturer / TM Owner

Chiesi Nv

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Indications & Clinical Uses

  • Inuvair, a fixed‑dose inhaled corticosteroid/long‑acting β2‑agonist combination, is used in the respiratory disease pathway for maintenance therapy.
  • Asthma: reduces airway inflammation and improves airflow for long‑term control.
  • Chronic obstructive pulmonary disease (COPD): provides bronchodilation and anti‑inflammatory action to decrease exacerbations.
  • Exercise‑induced bronchoconstriction: helps maintain open airways during physical activity.
  • Bronchial hyperresponsiveness: stabilises airway tone and reduces symptom frequency.

How It Works

  • Beclometasone dipropionate binds to intracellular glucocorticoid receptors, modulating gene transcription to suppress inflammatory cytokine production and reduce airway edema. Formoterol fumarate selectively stimulates β2‑adrenergic receptors on airway smooth muscle, increasing cyclic AMP levels, which leads to prolonged bronchodilation. The combined actions provide both anti‑inflammatory and sustained bronchodilator effects essential for maintenance therapy in obstructive lung diseases.

Side Effects

Inuvair may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Throat irritation or soreness.
  • Hoarseness or voice changes.
  • Oral candidiasis (thrush).
  • Cough or wheezing after inhalation.

Serious or Rare Side Effects

  • Paradoxical bronchospasm.
  • Adrenal suppression with prolonged high‑dose use.
  • Severe hypersensitivity reactions, including anaphylaxis.
  • Cardiac arrhythmias or tachycardia.
  • Pneumonia, especially in COPD patients.

Precautions & Warnings

  • Before prescribing Inuvair, clinicians should consider several safety measures.
  • Assess infection risk: evaluate for active respiratory infections prior to initiation.
  • Monitor growth in children: perform periodic assessment of growth velocity.
  • Use spacer device: reduce oropharyngeal deposition and improve drug delivery.
  • Avoid abrupt discontinuation: taper under medical supervision to prevent loss of disease control.
  • Store at ambient temperature: keep inhaler in original container, protect from moisture and heat.

Avoid Interactions

Inuvair can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Beta‑blockers: may diminish bronchodilator effect and precipitate bronchospasm.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole): increase systemic exposure to beclometasone.

Moderate Interactions (Monitor Closely)

  • Diuretics: may enhance hypokalaemia risk when combined with a β2‑agonist.
  • Theophylline: additive bronchodilator effect; monitor serum levels.
  • Live attenuated vaccines: corticosteroid component may reduce vaccine efficacy.

Frequently Asked Questions

Inuvair is a fixed‑dose inhaler that combines an inhaled corticosteroid with a long‑acting β2‑agonist. It is prescribed for the long‑term maintenance treatment of asthma and chronic obstructive pulmonary disease (COPD) to reduce inflammation, improve airway patency, and lower the risk of exacerbations.

Beclometasone dipropionate activates glucocorticoid receptors, suppressing inflammatory gene expression and decreasing airway swelling. Formoterol fumarate selectively stimulates β2‑adrenergic receptors, raising cyclic AMP levels in airway smooth muscle, which produces prolonged bronchodilation. Together they provide anti‑inflammatory and bronchodilator actions essential for disease control.

The dosage of Inuvair is individualized. A qualified prescriber determines the appropriate number of inhalations per day based on the patient’s age, disease severity, and response to therapy. Patients should follow the specific instructions provided by their healthcare professional.

Safety data for Inuvair in pregnancy and lactation are limited. The medication should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Healthcare providers should discuss individual risk factors and consider alternative treatments when appropriate.

To order Inuvair, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and assistance with import documentation.

Inuvair combines beclometasone, a potent corticosteroid, with formoterol, a rapid‑onset long‑acting β2‑agonist. Compared with other combinations such as budesonide/formoterol, Inuvair offers a similar dual mechanism but may differ in potency, particle size, and device design. Choice of inhaler depends on patient preference, inhalation technique, and clinical response.

Store Inuvair at ambient temperature, below 25 °C, in its original packaging. Keep the inhaler away from moisture, direct sunlight, and heat sources. Do not expose the device to freezing temperatures, and ensure the mouthpiece remains clean to maintain dose accuracy.

Inuvair is delivered via inhalation. The patient should shake the inhaler (if required), exhale fully, place the mouthpiece in the mouth, and inhale slowly and deeply while actuating the device. Holding the breath for about 10 seconds maximises drug deposition. Using a spacer can further reduce oropharyngeal deposition.

Serious risks include paradoxical bronchospasm, adrenal suppression with prolonged high‑dose use, severe hypersensitivity reactions such as anaphylaxis, and cardiac effects like tachycardia or arrhythmias. Patients should seek immediate medical attention if they experience sudden worsening of breathing, rash, swelling, or palpitations.

Inuvair is contraindicated in individuals with a known hypersensitivity to beclometasone, formoterol, or any excipients in the inhaler. It should also be avoided in patients who have experienced a severe allergic reaction to other inhaled corticosteroids or long‑acting β2‑agonists. Clinicians must assess each patient’s medical history before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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