Product image of Inuvair Nexthaler (Formoterol Fumarate Dihydrate, Beclometasone Dipropionate Anhydrous) supplied by GNH India

Inuvair Nexthaler

Active Ingredient:
Formoterol Fumarate Dihydrate, Beclometasone Dipropionate Anhydrous
Origin:
EU

Inuvair Nexthaler (Formoterol Fumarate Dihydrate, Beclometasone Dipropionate Anhydrous)

Beclometasone dipropionate and Formoterol fumarate, the active ingredients in Inuvair Nexthaler, are a combination inhaled corticosteroid and long‑acting beta2‑agonist presented as a dry‑powder inhaler for inhalation use. They treat asthma and chronic obstructive pulmonary disease in adults and adolescents.

GNH India supplies Inuvair Nexthaler as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Chiesi Nv

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Indications & Clinical Uses

  • Inuvair Nexthaler combines an inhaled corticosteroid and a long‑acting beta2‑agonist to manage chronic airway diseases.
  • Asthma: improves symptom control and reduces the frequency of exacerbations in patients with persistent asthma.
  • COPD: enhances bronchodilation and decreases exacerbation risk in patients with chronic obstructive pulmonary disease.

How It Works

  • Beclometasone dipropionate binds glucocorticoid receptors, modulating gene transcription to suppress airway inflammation. Formoterol fumarate stimulates beta2‑adrenergic receptors on bronchial smooth muscle, increasing cyclic AMP and causing rapid, sustained bronchodilation. The combined actions provide anti‑inflammatory effects together with long‑lasting airway relaxation.

Side Effects

Inuvair Nexthaler may cause a range of adverse reactions.

Common Side Effects

  • Throat irritation or soreness
  • Cough or wheeze after inhalation
  • Hoarseness of voice
  • Oral candidiasis (thrush)
  • Headache
  • Tremor or shakiness

Serious or Rare Side Effects

  • Paradoxical bronchospasm
  • Adrenal suppression with prolonged use
  • Pneumonia, especially in COPD patients
  • Cardiac arrhythmias or tachycardia
  • Severe hypersensitivity reactions (anaphylaxis)
  • Osteoporosis with long‑term high‑dose therapy

Precautions & Warnings

  • Before prescribing Inuvair Nexthaler, consider the following precautions.
  • Assess inhaler technique: ensure the patient can use a dry‑powder inhaler correctly.
  • Monitor for oral candidiasis: advise rinsing the mouth after each dose.
  • Screen for cardiovascular disease: use caution in patients with arrhythmias or ischemic heart disease.
  • Avoid abrupt discontinuation: taper under medical supervision to prevent loss of control.
  • Pregnancy and lactation: use only if the potential benefit justifies the potential risk.
  • Store at ambient temperature below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Inuvair Nexthaler can interact with several drug classes.

Major Interactions (Avoid)

  • Beta‑blockers: may diminish bronchodilator efficacy.
  • MAO inhibitors or tricyclic antidepressants: can increase cardiovascular side effects of formoterol.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may raise systemic exposure to beclometasone.

Moderate Interactions (Monitor Closely)

  • Diuretics: may exacerbate formoterol‑induced hypokalemia.
  • Theophylline: additive bronchodilator effect; monitor serum levels.
  • Anticholinergics: may increase risk of dry mouth and throat irritation.

Frequently Asked Questions

Inuvair Nexthaler is a prescription dry‑powder inhaler that combines beclometasone dipropionate and formoterol fumarate. It is indicated for the long‑term maintenance treatment of asthma and chronic obstructive pulmonary disease (COPD) in adults and adolescents, helping to control symptoms and reduce the risk of exacerbations.

Beclometasone dipropionate acts as an inhaled corticosteroid, binding to glucocorticoid receptors and suppressing inflammatory gene expression in the airways. Formoterol fumarate is a long‑acting beta2‑adrenergic agonist that stimulates beta2 receptors, increasing cyclic AMP and causing smooth‑muscle relaxation for sustained bronchodilation. Together they provide anti‑inflammatory and bronchodilatory effects.

The dose of Inuvair Nexthaler is determined by the prescribing clinician based on the severity of the patient’s asthma or COPD, age, and response to therapy. The prescriber will specify the number of inhalations per day and any step‑wise adjustments needed for optimal disease control.

The pregnancy category for Inuvair Nexthaler is not definitively established. It should only be used during pregnancy or lactation if the potential therapeutic benefit justifies any potential risk to the fetus or infant. Healthcare providers should discuss individual risk factors with the patient.

To order Inuvair Nexthaler, submit an enquiry on the product page at gnhindia.com, indicating the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide. After submission, the sales team will verify trade or institutional credentials and respond with pricing, availability, shipping details (including any cold‑chain requirements), and required import documentation.

Inuvair Nexthaler combines an inhaled corticosteroid (beclometasone) with a long‑acting beta2‑agonist (formoterol), similar to other combination inhalers such as budesonide/formoterol or fluticasone/salmeterol. Its dry‑powder inhaler format offers breath‑actuated delivery without propellants, which some patients prefer for ease of use and reduced coordination requirements.

Store Inuvair Nexthaler at ambient temperature below 25 °C, in its original packaging, and protect it from moisture and direct sunlight. Keep the inhaler out of reach of children and do not expose it to extreme heat or humidity, which could affect the powder’s integrity.

To use Inuvair Nexthaler, the patient should first exhale fully away from the device, then place the mouthpiece between the lips, inhale quickly and deeply through the mouth, and hold the breath for a few seconds before exhaling. The inhaler is breath‑actuated, so no manual actuation is required.

Serious risks include paradoxical bronchospasm, adrenal suppression with prolonged high‑dose use, pneumonia (particularly in COPD patients), cardiac arrhythmias or tachycardia, severe hypersensitivity reactions such as anaphylaxis, and osteoporosis with long‑term high‑dose corticosteroid exposure. Patients should seek immediate medical attention if they experience any of these events.

Inuvair Nexthaler is contraindicated in patients with a known hypersensitivity to beclometasone, formoterol, or any excipients in the inhaler. It should also be avoided in individuals who have experienced a severe allergic reaction to other inhaled corticosteroids or long‑acting beta2‑agonists. Patients with uncontrolled cardiovascular disease should use it only under close medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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