Product image of Inuvair Nexthaler (Formoterol Fumarate Dihydrate, Beclometasone Dipropionate Anhydrous) supplied by GNH India

Inuvair Nexthaler

Active Ingredient:
Formoterol Fumarate Dihydrate, Beclometasone Dipropionate Anhydrous
Origin:
EU

Inuvair Nexthaler (Formoterol Fumarate Dihydrate, Beclometasone Dipropionate Anhydrous)

Beclometasone dipropionate and formoterol fumarate, the active ingredients in Inuvair Nexthaler, are an inhaled corticosteroid/long‑acting β2‑agonist combination presented as a dry powder inhaler for inhalation use. It provides maintenance therapy for asthma and chronic obstructive pulmonary disease in adult patients and is indicated for long‑term control of airway symptoms and to reduce the risk of exacerbations.

GNH India supplies Inuvair Nexthaler as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product meets EU regulatory standards and is manufactured under GMP conditions.

Manufacturer / TM Owner

Chiesi Nv

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Indications & Clinical Uses

Inuvair Nexthaler combines an inhaled corticosteroid and a long‑acting β2‑agonist to manage chronic airway diseases.

  • Asthma: reduces airway inflammation and provides sustained bronchodilation for long‑term symptom control.
  • Chronic obstructive pulmonary disease (COPD): improves lung function and decreases the frequency of exacerbations as maintenance therapy.
  • Bronchospasm: delivers rapid, lasting bronchodilation to relieve bronchial constriction during episodes.

How It Works

  • Beclometasone dipropionate binds to intracellular glucocorticoid receptors, modulating gene transcription to suppress inflammatory cytokine production and reduce airway edema. Formoterol fumarate selectively stimulates β2‑adrenergic receptors on bronchial smooth muscle, increasing cyclic AMP levels, which leads to relaxation of the airway smooth muscle and prolonged bronchodilation. The combined actions provide anti‑inflammatory and bronchodilatory effects that maintain airway patency.

Side Effects

Inhalation of Inuvair Nexthaler may be associated with a range of adverse reactions, which are classified by frequency and severity.

Common Side Effects

  • Throat irritation or soreness
  • Hoarseness or voice changes
  • Oral candidiasis (thrush)
  • Cough or wheezing after inhalation
  • Headache
  • Tremor or palpitations

Serious or Rare Side Effects

  • Paradoxical bronchospasm
  • Severe allergic reactions (anaphylaxis, angioedema)
  • Adrenal suppression with prolonged high‑dose use
  • Cardiac arrhythmias
  • Pneumonia
  • Immunosuppression leading to opportunistic infections

Precautions & Warnings

Before prescribing Inuvair Nexthaler, clinicians should consider several precautionary measures to ensure safe use.

  • Monitor for oral thrush: rinse mouth with water and swallow after each inhalation.
  • Assess adrenal function: consider periodic evaluation in patients on long‑term high‑dose therapy.
  • Avoid use in patients with known hypersensitivity to beclometasone, formoterol, or any inhaler components.
  • Use the lowest effective dose to achieve control of symptoms.
  • Review concomitant β‑blocker therapy: may diminish bronchodilator response.
  • Store at room temperature below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Inuvair Nexthaler can interact with other medicines, influencing its efficacy or safety profile.

Major Interactions (Avoid)

  • Non‑selective β‑blockers: may antagonize the bronchodilator effect of formoterol.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): can increase systemic exposure to beclometasone.
  • Diuretics combined with high‑dose LABA: may heighten the risk of hypokalemia.

Moderate Interactions (Monitor Closely)

  • Theophylline: may have increased plasma concentrations when used with inhaled corticosteroids.
  • Ritonavir and other moderate CYP3A4 inhibitors: require monitoring of corticosteroid effects.
  • Live attenuated vaccines: inhaled corticosteroids may reduce vaccine efficacy; assess risk‑benefit.

Frequently Asked Questions

Inuvair Nexthaler is an inhaled combination of beclometasone dipropionate and formoterol fumarate indicated for the long‑term maintenance treatment of asthma and chronic obstructive pulmonary disease (COPD) in adult patients. It helps control airway inflammation and provides sustained bronchodilation to reduce symptoms and prevent exacerbations.

Beclometasone dipropionate is a synthetic corticosteroid that binds to glucocorticoid receptors inside airway cells. This binding alters gene transcription, leading to decreased production of inflammatory cytokines, reduced airway edema, and inhibition of immune cell activation, thereby lowering airway inflammation and hyper‑responsiveness.

The prescribed dose of Inuvair Nexthaler is determined by the treating physician based on the severity of the patient’s asthma or COPD and their response to therapy. Typically, the inhaler is used twice daily, but the exact number of inhalations per dose must follow the clinician’s instructions.

Safety data for beclometasone/formoterol use in pregnancy and lactation are limited. The medication should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Healthcare providers should evaluate each case individually and discuss potential risks with the patient.

To order Inuvair Nexthaler, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams across international markets. After the request, the sales team will verify trade or institutional credentials and respond with pricing, availability, shipping details (including any cold‑chain requirements) and required import documentation.

Inuvair Nexthaler contains beclometasone dipropionate and formoterol, offering a potent corticosteroid with a rapid‑onset, long‑acting β2‑agonist. Compared with alternatives such as budesonide/formoterol or fluticasone/salmeterol, beclometasone provides comparable anti‑inflammatory efficacy, while formoterol’s fast onset may give quicker symptom relief. Choice among products often depends on patient preference, device handling, and individual response.

Inuvair Nexthaler should be stored at room temperature below 25 °C, protected from moisture and direct sunlight. Keep the device in its original packaging until use. Do not expose the inhaler to extreme temperatures or humidity, as this may affect powder flow and dose consistency.

To use Inuvair Nexthaler, the patient should first exhale fully, then place the mouthpiece between the lips, seal tightly, and inhale sharply and deeply through the device. After inhalation, hold the breath for about 10 seconds before exhaling slowly. The inhaler is typically primed according to the manufacturer’s instructions before the first use.

Serious adverse events, although rare, include paradoxical bronchospasm, severe allergic reactions such as anaphylaxis or angioedema, adrenal suppression with prolonged high‑dose use, cardiac arrhythmias, and opportunistic infections like pneumonia. Patients should be instructed to seek immediate medical attention if they experience sudden worsening of breathing, swelling of the face or throat, or unexplained heart palpitations.

Inuvair Nexthaler is contraindicated in individuals with a known hypersensitivity to beclometasone dipropionate, formoterol fumarate, or any component of the inhaler device. It should also be avoided in patients who have experienced a severe allergic reaction to other inhaled corticosteroids or long‑acting β2‑agonists. Caution is advised for patients with uncontrolled cardiovascular disease, cardiac arrhythmias, or severe hypertension.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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