Product image of Inuver (Formoterol Fumarate Dihydrate, Beclometasone Dipropionate Anhydrous) supplied by GNH India

Inuver

Active Ingredient:
Formoterol Fumarate Dihydrate, Beclometasone Dipropionate Anhydrous
Origin:
EU

Inuver (Formoterol Fumarate Dihydrate, Beclometasone Dipropionate Anhydrous)

Beclometasone dipropionate / Formoterol fumarate, the active ingredient in Inuver, is an inhaled corticosteroid/long‑acting β2‑agonist combination presented as an inhalation product for inhalation use. It treats asthma and chronic obstructive pulmonary disease (COPD) in adult patients by reducing airway inflammation and providing sustained bronchodilation. The formulation is designed for delivery via a metered‑dose inhaler, ensuring rapid deposition in the lower respiratory tract.

GNH India supplies Inuver as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with a focus on quality and regulatory compliance.

Manufacturer / TM Owner

Chiesi Farmaceutici S.P.A.

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Indications & Clinical Uses

  • Inuver combines an inhaled corticosteroid with a long‑acting β2‑agonist to manage chronic airway diseases.
  • Asthma: improves symptom control and reduces the frequency of exacerbations
  • COPD: enhances lung function and decreases breathlessness during daily activities
  • Bronchial hyperresponsiveness: provides maintenance bronchodilation and anti‑inflammatory effect

How It Works

  • Beclometasone dipropionate binds to glucocorticoid receptors in airway cells, modulating gene transcription to suppress inflammatory cytokines, chemokines and cellular infiltration. Formoterol fumarate selectively stimulates β2‑adrenergic receptors on bronchial smooth muscle, activating adenylate cyclase and increasing cyclic AMP, which relaxes smooth muscle and inhibits mast cell mediator release. The combined actions reduce airway inflammation and produce sustained bronchodilation.

Side Effects

Inhalation of Inuver may be associated with a range of adverse reactions, which are categorized by frequency.

Common Side Effects

  • Throat irritation or soreness
  • Oral candidiasis (thrush)
  • Headache

Serious or Rare Side Effects

  • Paradoxical bronchospasm
  • Severe allergic reaction (anaphylaxis)
  • Adrenal suppression with prolonged high‑dose use

Precautions & Warnings

  • Before using Inuver, patients and clinicians should consider several safety measures.
  • Assess asthma or COPD control before initiating therapy: ensure patient is stable
  • Monitor for oral thrush: advise rinsing mouth after each inhalation
  • Use the lowest effective dose to maintain symptom control
  • Avoid abrupt discontinuation: taper under medical supervision
  • Caution in patients with cardiovascular disease: monitor heart rate and blood pressure
  • Store at ambient temperature: keep in original container, protect from moisture and heat

Avoid Interactions

Inuver may interact with other medicines; awareness of these interactions helps maintain safety.

Major Interactions (Avoid)

  • Non‑selective beta‑blockers: may diminish bronchodilator effect and precipitate bronchospasm
  • Strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir): increase systemic exposure to both components
  • Diuretics (e.g., furosemide): may potentiate hypokalemia when combined with formoterol

Moderate Interactions (Monitor Closely)

  • Diabetes medications: β2‑agonist may raise blood glucose levels
  • Theophylline: additive stimulant effect on the cardiovascular system
  • Vaccines (live attenuated): inhaled steroids may reduce immune response

Frequently Asked Questions

Inuver is a prescription inhalation medication that combines beclometasone dipropionate, an inhaled corticosteroid, with formoterol fumarate, a long‑acting β2‑agonist. It is indicated for the maintenance treatment of asthma and chronic obstructive pulmonary disease (COPD) in adults, helping to control symptoms, reduce inflammation, and improve lung function.

Beclometasone dipropionate binds to glucocorticoid receptors in airway epithelial and inflammatory cells. This interaction modulates gene expression, suppressing the production of cytokines, chemokines, and other mediators that drive airway inflammation, thereby decreasing swelling, mucus production and hyper‑responsiveness.

Formoterol fumarate is a selective long‑acting β2‑adrenergic agonist. It activates β2 receptors on bronchial smooth muscle, stimulating adenylate cyclase and raising intracellular cyclic AMP levels. The rise in cAMP leads to relaxation of smooth muscle and inhibition of mast cell mediator release, providing sustained bronchodilation for up to 12 hours.

The prescribed dose of Inuver is determined individually by a qualified healthcare professional based on the severity of the patient’s asthma or COPD, age, and response to therapy. The prescriber selects the appropriate number of inhalations per day and may adjust the regimen during follow‑up visits. No generic dosing information is provided here.

Safety data for beclometasone dipropionate and formoterol fumarate in pregnancy or lactation are limited. The medication should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Healthcare providers should discuss risks and consider alternative treatments when appropriate.

To place an order, submit an enquiry on the Inuver product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. The sales team then provides pricing, availability, shipping details (including any cold‑chain requirements) and assists with import documentation.

Compared with single‑component inhalers, the fixed‑dose combination of beclometasone and formoterol offers both anti‑inflammatory and bronchodilator actions in one device, which can improve adherence and simplify regimens. Alternatives such as separate inhaled corticosteroid and short‑acting β2‑agonist inhalers require multiple steps, while other LABA/ICS combos may differ in potency, dosing frequency or device type.

Inuver inhalers should be stored at ambient temperature, preferably below 25 °C, in the original packaging to protect the device from moisture and direct sunlight. Keep the inhaler out of reach of children and avoid exposing it to extreme heat or freezing conditions, which could affect the dose‑metering mechanism.

Inuver is delivered via a metered‑dose inhaler. The patient should exhale fully, place the mouthpiece in the mouth, seal lips around it, and press the canister to release a puff while inhaling slowly and deeply. After inhalation, hold the breath for a few seconds, then exhale. The device should be primed according to the manufacturer’s instructions before first use and periodically as recommended.

Inuver is contraindicated in patients with a known hypersensitivity to beclometasone, formoterol, or any excipients in the inhaler. It should also be avoided in individuals who have experienced a severe paradoxical bronchospasm with β2‑agonists. Caution is advised for patients with uncontrolled cardiovascular disorders, such as arrhythmias or hypertension, and for those receiving non‑selective beta‑blockers.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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