Product image of Inventum (Sildenafil Citrate) supplied by GNH India

Inventum

Active Ingredient:
Sildenafil Citrate
Origin:
EU

Inventum (Sildenafil Citrate)

Sildenafil citrate, the active ingredient in Inventum, is a phosphodiesterase type 5 inhibitor presented as an oral tablet for oral use. It is prescribed to treat erectile dysfunction in adult males and to improve exercise capacity in patients with pulmonary arterial hypertension.

GNH India supplies Inventum as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory compliance across all markets. The company follows stringent Good Distribution Practice standards and provides reliable logistics for timely delivery.

Manufacturer / TM Owner

Aflofarm Farmacja Polska Sp. Z O.O.

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Indications & Clinical Uses

  • Inventum (sildenafil citrate) acts on the nitric‑oxide/cGMP pathway to address conditions related to vascular smooth‑muscle tone.
  • Erectile dysfunction: enhances ability to achieve and maintain an erection sufficient for sexual activity.
  • Pulmonary arterial hypertension: improves exercise capacity and reduces pulmonary vascular resistance in affected patients.
  • Sexual dysfunction associated with certain medical conditions: assists in achieving satisfactory sexual performance when underlying disease contributes to erectile issues.

How It Works

  • Sildenafil citrate selectively inhibits the enzyme phosphodiesterase type 5 (PDE5) in vascular smooth‑muscle cells. By blocking PDE5, it prevents the breakdown of cyclic guanosine monophosphate (cGMP), allowing cGMP to accumulate. Elevated cGMP leads to relaxation of smooth muscle in the corpus cavernosum and pulmonary vasculature, increasing blood flow and facilitating erection or reducing pulmonary arterial pressure. The effect is activity‑dependent, occurring primarily during sexual stimulation or when pulmonary arterial pressure is elevated.

Side Effects

Sildenafil citrate may be associated with a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Headache
  • Facial flushing
  • Dyspepsia or indigestion
  • Nasal congestion
  • Visual disturbances (e.g., blurred vision)
  • Back pain or muscle aches

Serious or Rare Side Effects

  • Priapism (prolonged erection)
  • Sudden hearing loss
  • Severe hypotension
  • Myocardial infarction or acute coronary syndrome
  • Stroke or transient ischemic attack
  • Vision loss due to retinal vascular events

Precautions & Warnings

When prescribing Inventum, clinicians should consider several safety measures.

  • Cardiovascular assessment: evaluate the patient’s ability to engage in sexual activity and screen for recent myocardial infarction.
  • Concurrent nitrate therapy: avoid use due to risk of severe hypotension.
  • Use in patients with severe renal or hepatic impairment: dose adjustment may be required.
  • Monitor for visual changes: discontinue if sudden loss of vision occurs.
  • Avoid use in patients with known hypersensitivity to sildenafil.
  • Store at ambient temperature below 25°C: keep in the original pack, protect from moisture and light.

Avoid Interactions

Sildenafil citrate can interact with several medicines, requiring careful management.

Major Interactions (Avoid)

  • Nitrates (e.g., nitroglycerin, isosorbide dinitrate)
  • Guanylate cyclase stimulators (e.g., riociguat)
  • Nitric oxide donors used for pulmonary hypertension
  • Other phosphodiesterase‑5 inhibitors (e.g., tadalafil, vardenafil)

Moderate Interactions (Monitor Closely)

  • Alpha‑blockers (e.g., tamsulosin)
  • Antihypertensive agents (may enhance blood‑pressure lowering)
  • Strong CYP3A4 inhibitors (e.g., erythromycin, ketoconazole)
  • CYP3A4 inducers (e.g., rifampin, carbamazepine)
  • Protease inhibitors (e.g., ritonavir) which can increase sildenafil exposure

Frequently Asked Questions

Inventum contains sildenafil citrate and is prescribed to treat erectile dysfunction in adult males and to improve exercise capacity in patients with pulmonary arterial hypertension. It works by enhancing blood flow to the penis or the pulmonary vasculature, depending on the condition being managed.

Sildenafil citrate selectively blocks phosphodiesterase type 5, an enzyme that degrades cyclic GMP. By inhibiting this enzyme, cyclic GMP accumulates, causing smooth‑muscle relaxation in the corpus cavernosum and pulmonary arteries, which increases blood flow and facilitates erection or lowers pulmonary arterial pressure.

The appropriate dose of Inventum is individualized by the prescribing clinician based on the patient’s medical condition, severity of symptoms, concomitant medications, and renal or hepatic function. No fixed regimen is provided here; the prescriber sets the dose and dosing schedule.

Sildenafil citrate is not recommended for use during pregnancy or while breastfeeding because safety data are limited. Women who are pregnant, planning to become pregnant, or nursing should avoid the medication unless a healthcare professional determines that the potential benefits outweigh the risks.

To order Inventum, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

The most common alternative within the same class is tadalafil, another PDE5 inhibitor. Both improve erectile function, but tadalafil has a longer half‑life, allowing once‑daily dosing for some patients, whereas sildenafil typically requires dosing about one hour before sexual activity. Choice depends on patient preference, duration of action needed, and individual tolerability.

Inventum tablets should be stored at ambient temperature below 25 °C. Keep them in the original packaging, protect from moisture and light, and store out of reach of children. Do not store in a refrigerator or freezer.

Inventum is taken orally, usually with a glass of water. The tablet is swallowed whole and should be taken about 30–60 minutes before anticipated sexual activity or as directed for pulmonary arterial hypertension. Food may delay absorption, so patients can follow their prescriber’s advice regarding meals.

Serious adverse events include priapism (an erection lasting longer than four hours), sudden hearing loss, severe hypotension, myocardial infarction, stroke, and vision loss due to retinal vascular events. If any of these occur, the medication should be stopped immediately and emergency medical care sought.

Inventum should be avoided in patients who take nitrates, have had a recent myocardial infarction or stroke, have uncontrolled severe hypertension, severe heart failure, or known hypersensitivity to sildenafil or any tablet excipients. It is also contraindicated in patients with certain retinal disorders such as retinitis pigmentosa.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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