Product image of Invicorp (Phentolamine Mesilate, Aviptadil) supplied by GNH India

Invicorp

Active Ingredient:
Phentolamine Mesilate, Aviptadil
Origin:
EU

Invicorp (Phentolamine Mesilate, Aviptadil)

Phentolamine mesilate and aviptadil, the active ingredients in Invicorp, are vasodilators presented as a sterile solution for intracavernous use. It treats erectile dysfunction by enhancing penile blood flow in adult males.

GNH India supplies Invicorp as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Evolan Pharma Ab

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Indications & Clinical Uses

  • Invicorp is indicated for conditions affecting penile vascular function and erectile capacity.
  • Erectile dysfunction: improves erection quality by increasing blood flow to the corpus cavernosum.
  • Vasculogenic erectile dysfunction: restores smooth‑muscle relaxation in penile tissue.
  • Refractory erectile dysfunction: offers an alternative when oral PDE5 inhibitors are ineffective.

How It Works

  • Invicorp combines an alpha‑adrenergic antagonist (phentolamine) that blocks vasoconstriction with a vasoactive intestinal peptide analog (aviptadil) that raises intracellular cAMP. The dual action relaxes smooth muscle in the corpus cavernosum, dilates penile arteries, and enhances blood inflow, facilitating erection.

Side Effects

Adverse reactions may occur with intracavernous administration.

Common Side Effects

  • Penile pain or discomfort
  • Local bruising or hematoma at injection site
  • Transient headache
  • Flushing or warmth sensation
  • Mild hypotension
  • Nausea

Serious or Rare Side Effects

  • Priapism lasting longer than four hours
  • Severe hypotension leading to dizziness or syncope
  • Allergic reaction with rash, itching, or swelling
  • Vascular injury or fibrosis at injection site

Precautions & Warnings

  • Use Invicorp only under medical supervision and after confirming diagnosis.
  • Allergy assessment: verify no known hypersensitivity to phentolamine, aviptadil, or formulation excipients.
  • Cardiovascular evaluation: avoid in patients with uncontrolled hypertension or recent myocardial infarction.
  • Concurrent vasodilators: monitor for additive blood pressure effects.
  • Pregnancy and lactation: contraindicated unless benefits outweigh risks.
  • Storage: Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Potential drug interactions should be reviewed before therapy.

Major Interactions (Avoid)

  • Nitrates: combined use may cause profound hypotension.
  • Alpha‑blockers: additive vasodilatory effect leading to severe blood pressure drop.

Moderate Interactions (Monitor Closely)

  • Antihypertensive agents: may require dose adjustment.
  • PDE5 inhibitors: monitor for excessive penile erection.
  • Monoamine oxidase inhibitors: watch for blood pressure fluctuations.

Frequently Asked Questions

Invicorp is an intracavernous injectable indicated for the treatment of erectile dysfunction in adult males. It works by enhancing penile blood flow, helping men achieve and maintain an erection sufficient for sexual activity.

Phentolamine mesilate blocks alpha‑adrenergic receptors, preventing vasoconstriction, while aviptadil, a peptide analog, raises intracellular cAMP levels. Together they relax smooth muscle in the corpus cavernosum, dilate penile arteries, and increase blood inflow to facilitate erection.

The dose of Invicorp is determined by the prescribing clinician based on the patient’s condition, response, and safety considerations. Healthcare professionals calculate the appropriate volume and concentration for each intracavernous injection.

Invicorp is not recommended for use in pregnancy or while breastfeeding because safety data are lacking. The product is intended for adult male patients with erectile dysfunction, and its use in women is contraindicated.

To order Invicorp, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Unlike oral PDE5 inhibitors, Invicorp is an injectable vasodilator that directly relaxes penile smooth muscle, offering rapid onset and an option for patients who do not respond to oral therapy. It provides a mechanical alternative rather than a systemic oral medication.

Invicorp should be stored at 2‑8 °C in a refrigerator, protected from light, and must not be frozen or shaken. Keep the product in its original packaging to maintain sterility and potency until use.

Invicorp is administered by a trained healthcare professional via intracavernous injection directly into the corpus cavernosum of the penis. Proper aseptic technique and dosage calculation are essential for safe and effective use.

The most serious risks include priapism lasting longer than four hours, severe hypotension that can cause dizziness or fainting, and rare allergic reactions such as rash, swelling, or anaphylaxis. Prompt medical attention is required if these events occur.

Invicorp should not be used by patients with known hypersensitivity to phentolamine, aviptadil, or any formulation components, those with uncontrolled hypertension, recent myocardial infarction, or severe cardiovascular disease, and it is contraindicated in women, pregnant or lactating individuals.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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