Product image of Invicorp (Phentolamine Mesilate, Aviptadil) supplied by GNH India

Invicorp

Active Ingredient:
Phentolamine Mesilate, Aviptadil
Origin:
EU

Invicorp (Phentolamine Mesilate, Aviptadil)

Phentolamine mesilate, the active ingredient in Invicorp, is a Alpha-adrenergic antagonist presented as an injectable solution for intracavernous use. It is combined with aviptadil, a vasoactive intestinal peptide analog, to treat erectile dysfunction in adult males.
GNH India supplies Invicorp as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Evolan Pharma Ab

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Indications & Clinical Uses

Invicorp, containing phentolamine mesilate and aviptadil, is used in the management of erectile dysfunction.

  • Erectile dysfunction: improves penile erection by enhancing blood flow to the corpora cavernosa.
  • Penile vascular insufficiency: promotes vasodilation of penile arteries to support adequate perfusion.
  • Post‑surgical penile rehabilitation: aids recovery of erectile function after procedures affecting penile blood supply.

How It Works

  • Phentolamine mesilate blocks alpha‑adrenergic receptors on penile smooth muscle, causing vasodilation of the cavernosal arteries. Aviptadil, a synthetic analogue of vasoactive intestinal peptide, raises intracellular cAMP levels, leading to smooth‑muscle relaxation and further increase in penile blood flow. The combined actions result in enhanced arterial inflow and erection.

Side Effects

Adverse reactions may occur with intracavernous administration of Invicorp.

Common Side Effects

  • Penile pain or discomfort.
  • Local bruising or hematoma at injection site.
  • Headache.
  • Flushing.
  • Dizziness.
  • Transient hypotension.

Serious or Rare Side Effects

  • Priapism lasting longer than four hours.
  • Severe hypotension with syncope.
  • Allergic reaction including rash, itching, or anaphylaxis.
  • Cardiovascular events such as myocardial infarction.
  • Vision changes or ocular disturbances.
  • Hematuria or urinary retention.

Precautions & Warnings

Before using Invicorp, consider the following safety measures.

  • Cardiovascular disease: avoid if uncontrolled hypertension or recent myocardial infarction.
  • Bleeding disorders: use with caution in patients on anticoagulants.
  • Concurrent alpha‑blockers: monitor for additive hypotensive effects.
  • Allergy history: assess for hypersensitivity to phentolamine, aviptadil, or formulation excipients.
  • Pregnancy and lactation: safety not established; avoid use.
  • Storage: Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Invicorp may interact with other medications.

Major Interactions (Avoid)

  • Oral or intravenous alpha‑adrenergic antagonists: risk of profound hypotension.
  • Nitrates: additive vasodilatory effect leading to severe blood pressure drop.
  • Phosphodiesterase‑5 inhibitors: increased risk of priapism.

Moderate Interactions (Monitor Closely)

  • Antihypertensive agents: may require dose adjustment.
  • Anticoagulants/antiplatelet drugs: heightened bleeding risk at injection site.
  • CYP450 modulators: potential impact on aviptadil metabolism.

Frequently Asked Questions

Invicorp is indicated for the treatment of erectile dysfunction. It combines phentolamine mesilate, an alpha‑adrenergic antagonist, with aviptadil, a vasoactive intestinal peptide analogue, to enhance penile blood flow and facilitate erection when administered intracavernously.

Phentolamine mesilate blocks alpha‑adrenergic receptors on penile smooth muscle, causing vasodilation of the cavernosal arteries. This increases arterial inflow to the penis, supporting the development of an erection.

The appropriate dose of Invicorp is determined by the prescribing clinician based on the patient’s condition, response, and safety considerations. Dosage instructions are provided on the prescription label.

Safety of Invicorp in pregnancy or lactation has not been established. It is generally avoided in pregnant or nursing individuals unless the potential benefit justifies the potential risk, as assessed by a qualified healthcare professional.

To order Invicorp, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where needed) and import documentation.

Unlike oral phosphodiesterase‑5 inhibitors, Invicorp is delivered directly into the corpora cavernosa, providing rapid onset of action. Its dual mechanism—alpha‑blockade and peptide‑mediated smooth‑muscle relaxation—offers an alternative for patients who do not respond adequately to oral agents or who require on‑demand therapy.

Invicorp should be stored at 2‑8 °C in a refrigerator. Keep the product in its original packaging, protect it from light, and avoid freezing or shaking the vial to maintain stability.

Invicorp is administered by intracavernous injection. A qualified healthcare professional injects the prepared solution directly into the penile corpora cavernosa using a sterile technique, following standard aseptic procedures.

The most serious risks include priapism lasting longer than four hours, severe hypotension leading to syncope, and rare allergic reactions such as anaphylaxis. Prompt medical attention is required if any of these events occur.

Invicorp is contraindicated in patients with known hypersensitivity to phentolamine, aviptadil, or any formulation excipients, as well as those with uncontrolled hypertension, recent myocardial infarction, or severe cardiovascular disease where vasodilation could be hazardous.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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