Product image of Invicorp (Phentolamine Mesilate, Aviptadil) supplied by GNH India

Invicorp

Active Ingredient:
Phentolamine Mesilate, Aviptadil
Origin:
EU

Invicorp (Phentolamine Mesilate, Aviptadil)

Phentolamine mesilate and aviptadil, the active ingredient in Invicorp, is an alpha‑adrenergic antagonist and vasoactive intestinal peptide analog presented as an intracavernous injection for the treatment of erectile dysfunction in adult males. The combination works by blocking alpha‑adrenergic receptors to induce vasodilation and by stimulating smooth‑muscle relaxation through cAMP elevation, together enhancing penile blood flow.

GNH India supplies Invicorp as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory compliance across markets.

Manufacturer / TM Owner

Evolan Pharma Ab

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Invicorp acts on the penile vascular system to restore normal erectile function.

  • Erectile dysfunction: improves erection quality by increasing blood flow to the corpus cavernosum.
  • Penile vascular insufficiency: enhances arterial inflow to support adequate rigidity.
  • Post‑operative penile rehabilitation: aids recovery of erectile function after surgical procedures.

How It Works

  • Phentolamine mesilate antagonizes alpha‑adrenergic receptors on penile arterial smooth muscle, causing vasodilation, while aviptadil, a vasoactive intestinal peptide analog, binds to VIP receptors, raising intracellular cAMP and promoting smooth‑muscle relaxation. The combined effect increases blood volume within the corpus cavernosum, facilitating erection.

Side Effects

Adverse reactions may occur following intracavernous administration.

Common Side Effects

  • Injection site pain: mild to moderate discomfort at the injection site.
  • Bruising or hematoma: localized bleeding under the skin.
  • Swelling: transient edema of the penis.
  • Erythema: redness around the injection area.
  • Headache: occasional mild headache.
  • Dizziness: transient light‑headedness.

Serious or Rare Side Effects

  • Priapism: prolonged erection lasting more than four hours.
  • Severe hypotension: sudden drop in blood pressure requiring medical attention.
  • Allergic reaction: rash, itching, or anaphylaxis.
  • Cardiovascular collapse: rare but life‑threatening drop in circulatory function.
  • Infection at injection site: signs of redness, warmth, or purulent discharge.
  • Prolonged erection with tissue damage: risk of penile fibrosis if untreated.

Precautions & Warnings

Before using Invicorp, consider the following safety measures.

  • Contraindicated in severe cardiovascular disease: risk of dangerous hypotension.
  • Avoid in patients with known hypersensitivity to phentolamine or aviptadil: may trigger allergic reactions.
  • Use caution in sickle cell disease: increased risk of priapism.
  • Monitor blood pressure before and after injection: watch for sudden drops.
  • Review concomitant vasodilator therapy: adjust dosing as needed.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Invicorp may interact with several medication classes.

Major Interactions (Avoid)

  • Nitrates: additive vasodilation can cause severe hypotension.
  • Alpha‑blockers: combined effect may lead to profound blood pressure fall.
  • PDE5 inhibitors: heightened risk of priapism.

Moderate Interactions (Monitor Closely)

  • Antihypertensives: may require dose adjustment and close blood pressure monitoring.
  • Beta‑blockers: monitor heart rate and hemodynamic response.
  • Diuretics: watch for electrolyte disturbances and volume depletion.

Frequently Asked Questions

Invicorp is indicated for the treatment of erectile dysfunction. It is administered by intracavernous injection to improve penile blood flow, helping men achieve and maintain an erection sufficient for sexual activity.

Phentolamine mesilate blocks alpha‑adrenergic receptors, causing vasodilation of penile arteries. Aviptadil, a vasoactive intestinal peptide analog, stimulates smooth‑muscle relaxation via cAMP elevation. Together they increase blood volume in the corpus cavernosum, facilitating erection.

The dose of Invicorp is determined by the prescribing clinician based on the patient’s condition, response, and safety considerations. The prescriber will select the appropriate volume and concentration for each intracavernous administration.

Invicorp is intended for adult male patients with erectile dysfunction and is not indicated for use in pregnant or breastfeeding individuals. Safety data for these populations are not available, and the product should be avoided in such cases.

To order Invicorp, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and import documentation.

Unlike oral phosphodiesterase‑5 inhibitors, Invicorp is an injectable combination that directly induces penile vasodilation and smooth‑muscle relaxation. It can be effective in patients who do not respond to oral agents, but it requires administration by a trained professional and carries injection‑related risks.

Invicorp should be stored at 2‑8 °C in a refrigerator, protected from light, and must not be frozen or shaken. Keep the product in its original packaging until use to maintain stability and potency.

Invicorp is given as an intracavernous injection directly into the corpora cavernosa of the penis. The procedure should be performed by a qualified healthcare professional using aseptic technique and the appropriate injection equipment.

Serious risks include priapism (prolonged erection lasting more than four hours), severe hypotension, allergic reactions, and cardiovascular collapse. Prompt medical attention is required if any of these events occur.

Invicorp should not be used by patients with severe cardiovascular disease, known hypersensitivity to phentolamine mesilate or aviptadil, or those taking nitrates, alpha‑blockers, or PDE5 inhibitors without medical supervision. Contraindications must be evaluated by the prescribing clinician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Phentolamine Mesilate, Aviptadil

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT