Product image of Invicorp (Phentolamine Mesilate, Aviptadil) supplied by GNH India

Invicorp

Active Ingredient:
Phentolamine Mesilate, Aviptadil
Origin:
EU

Invicorp (Phentolamine Mesilate, Aviptadil)

Phentolamine mesilate and Aviptadil, the active ingredients in Invicorp, are an alpha‑adrenergic antagonist and a vasoactive intestinal peptide analog presented as an injectable formulation for intracavernous use. By inducing vasodilation of penile arteries and relaxing smooth muscle, they increase intracavernous blood flow to treat erectile dysfunction in adult males.

GNH India supplies Invicorp as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution.

Manufacturer / TM Owner

Evolan Pharma Ab

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Indications & Clinical Uses

  • Invicorp acts on the penile vascular system to improve erectile function.
  • Erectile dysfunction (general): facilitates erection by increasing blood flow to the penis.
  • Penile arterial insufficiency: improves penile blood flow to support erection.
  • Post‑prostatectomy erectile dysfunction: aids recovery of erectile function after surgery.

How It Works

  • Phentolamine mesilate is a non‑selective alpha‑adrenergic antagonist that blocks α1 and α2 receptors on penile arterial smooth muscle, producing vasodilation. Aviptadil is a synthetic analogue of vasoactive intestinal peptide that binds VIP receptors on smooth muscle, causing relaxation and further vasodilation. The combined effect enhances intracavernous blood inflow, raising intracavernous pressure and enabling erection when sexual stimulation occurs.

Side Effects

Common and serious adverse reactions have been reported with intracavernous administration of Invicorp.

Common Side Effects

  • Pain at the injection site
  • Bruising or hematoma
  • Priapism (prolonged erection)
  • Headache

Serious or Rare Side Effects

  • Severe hypotension
  • Allergic reaction (anaphylaxis)

Precautions & Warnings

  • Precautions should be observed to minimize risks associated with intracavernous use of Invicorp.
  • Contraindication: avoid use in patients with known hypersensitivity to either component.
  • Cardiovascular risk: assess for severe coronary artery disease before administration.
  • Coagulation disorders: use with caution in patients with bleeding tendencies.
  • Concurrent use of nitrates or other vasodilators: may cause excessive hypotension.
  • Priapism history: monitor closely for prolonged erections.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Invicorp may interact with other agents that affect vascular tone or blood pressure.

Major Interactions (Avoid)

  • Nitrates (e.g., nitroglycerin): combined vasodilation can cause severe hypotension.
  • Alpha‑blockers (e.g., prazosin): additive blood pressure lowering effect.
  • PDE5 inhibitors (e.g., sildenafil) when used simultaneously: risk of prolonged erection.

Moderate Interactions (Monitor Closely)

  • Antihypertensives (e.g., beta‑blockers): may require dose adjustment.
  • Anticoagulants (e.g., warfarin): increased risk of bleeding at injection site.
  • Selective serotonin reuptake inhibitors (SSRIs): may affect sexual response.

Frequently Asked Questions

Invicorp is an injectable combination of phentolamine mesilate and aviptadil that is used to treat erectile dysfunction. By increasing blood flow to the penis, it helps men achieve and maintain an erection sufficient for sexual activity.

Phentolamine mesilate blocks alpha‑adrenergic receptors on penile arterial smooth muscle, preventing vasoconstriction. This blockade leads to relaxation of the vessels, allowing more blood to enter the corpora cavernosa and supporting erection when sexual stimulation occurs.

The dose of Invicorp is determined by the prescribing physician based on the patient’s clinical condition, response, and safety considerations. No fixed regimen is provided publicly; the prescriber tailors the amount and frequency of intracavernous injection.

Safety data for Invicorp in pregnant or nursing women are lacking. Because the drug is intended for adult males with erectile dysfunction, it is generally not recommended for use during pregnancy or while breastfeeding.

To order Invicorp, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Unlike oral PDE5 inhibitors that rely on systemic enzyme inhibition, Invicorp is administered directly into the penis and produces rapid vasodilation. It can be useful when oral agents are ineffective or contraindicated, but it requires professional injection and monitoring for local side effects.

Invicorp should be stored at 2‑8 °C in a refrigerator, protected from light and moisture. Do not freeze or shake the vial. Before use, allow the product to reach room temperature if required, and follow aseptic technique for intracavernous injection.

Invicorp is given as an intracavernous injection. A qualified healthcare professional injects the prescribed volume directly into the corpora cavernosa of the penis using a sterile needle and syringe, typically shortly before sexual activity.

The most serious adverse events include priapism (an erection lasting longer than four hours), severe hypotension that can cause dizziness or fainting, and rare allergic reactions such as anaphylaxis. Immediate medical attention is required if any of these occur.

Invicorp should not be used by individuals with known hypersensitivity to phentolamine mesilate, aviptadil, or any excipients, patients with severe coronary artery disease, uncontrolled hypertension, bleeding disorders, or those who have experienced priapism previously. Consultation with a physician is essential before starting therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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