Product image of Invicorp (Phentolamine Mesilate, Aviptadil) supplied by GNH India

Invicorp

Active Ingredient:
Phentolamine Mesilate, Aviptadil
Origin:
EU

Invicorp (Phentolamine Mesilate, Aviptadil)

Phentolamine Mesilate / Aviptadil, the active ingredient in Invicorp, is an alpha-adrenergic antagonist and vasoactive intestinal peptide analog presented as a formulation for intracavernous use. It is used to treat erectile dysfunction in adult males. GNH India supplies Invicorp as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Evolan Pharma Ab

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Indications & Clinical Uses

Invicorp acts on the penile vascular system to improve erectile function.

  • Erectile dysfunction (organic): enhances penile blood flow to achieve satisfactory erections.
  • Erectile dysfunction (post‑prostatectomy): facilitates recovery of erectile capacity after surgical nerve damage.
  • Erectile dysfunction (diabetes‑related): counteracts vascular insufficiency associated with diabetic neuropathy.

How It Works

  • Phentolamine mesilate blocks alpha‑adrenergic receptors on penile smooth muscle, causing vasodilation, while aviptadil, a synthetic vasoactive intestinal peptide analog, raises intracellular cAMP levels to promote smooth‑muscle relaxation. The combined effect increases arterial inflow and reduces venous outflow, facilitating erection when administered intracavernously.

Side Effects

Common Side Effects

  • Pain or discomfort at the injection site
  • Bruising or hematoma formation
  • Transient hypotension or dizziness
  • Headache or flushing
  • Mild nausea
  • Localized swelling

Serious or Rare Side Effects

  • Priapism lasting longer than four hours
  • Severe hypotension leading to syncope
  • Allergic reactions such as rash, itching, or anaphylaxis
  • Cardiovascular events including myocardial ischemia
  • Infection at the injection site
  • Penile fibrosis or tissue damage

Precautions & Warnings

Precautions should be observed before and during use of Invicorp.

  • Cardiovascular assessment: evaluate heart disease risk before administration.
  • Nitrate therapy: avoid concurrent use due to risk of profound hypotension.
  • Blood pressure monitoring: check baseline and post‑injection values.
  • Medical supervision: only administer under qualified healthcare professional guidance.
  • Store at ambient temperature: keep in original packaging, protect from moisture and light.

Avoid Interactions

Potential drug interactions must be considered.

Major Interactions (Avoid)

  • Nitrates: may cause severe hypotension.
  • Alpha‑blockers: additive vasodilatory effect.
  • PDE5 inhibitors: increased risk of priapism.
  • Antihypertensives: excessive blood pressure drop.
  • Monoamine oxidase inhibitors: unpredictable vascular response.

Moderate Interactions (Monitor Closely)

  • Antihistamines: may blunt vasodilatory response.
  • Certain antidepressants: possible alteration of vascular tone.
  • Alcohol: can enhance hypotensive effects.
  • CYP450 modulators: may affect drug metabolism.
  • Other vasodilators: monitor for additive blood pressure changes.

Frequently Asked Questions

Invicorp is a prescription medication indicated for the treatment of erectile dysfunction in adult males. It is administered by intracavernous injection to improve penile blood flow and facilitate the achievement of a satisfactory erection.

Phentolamine mesilate blocks alpha‑adrenergic receptors, causing vasodilation of penile tissue. Aviptadil, a synthetic analogue of vasoactive intestinal peptide, raises intracellular cAMP, leading to smooth‑muscle relaxation. Together they increase arterial inflow and reduce venous outflow, supporting erection.

The appropriate dose of Invicorp is determined by the prescribing clinician based on the patient’s condition, response, and safety considerations. Dosage instructions are individualized and should be followed exactly as prescribed.

Invicorp is intended for adult male patients with erectile dysfunction and is not indicated for use in pregnant or breastfeeding individuals. Safety data for these populations are not available, and the product should not be used by women.

To order Invicorp, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Invicorp combines an alpha‑adrenergic antagonist with a vasoactive peptide, offering rapid onset of action via intracavernous injection. Unlike oral PDE5 inhibitors, it acts directly on penile vasculature and can be useful when oral agents are ineffective or contraindicated.

Invicorp should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original container, protect it from moisture and direct light, and avoid freezing. Follow any additional handling instructions provided by the supplier.

Invicorp is administered by a trained healthcare professional as an intracavernous injection directly into the penile tissue. Proper aseptic technique and correct injection site selection are essential to ensure efficacy and minimize adverse effects.

The most serious risks include priapism (prolonged erection lasting more than four hours), severe hypotension, allergic reactions such as anaphylaxis, and cardiovascular events. Immediate medical attention is required if any of these occur.

Invicorp should not be used by patients with known hypersensitivity to phentolamine, aviptadil, or any excipients, those taking nitrates or certain antihypertensive agents, individuals with severe cardiovascular disease, or anyone for whom intracavernous injection is contraindicated.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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