Product image of Invirum (Aciclovir) supplied by GNH India

Invirum

Active Ingredient:
Aciclovir
Origin:
EU

Invirum (Aciclovir)

Aciclovir, the active ingredient in Invirum, is an antiviral presented as an oral formulation for oral use. It treats herpes simplex virus infections, herpes zoster (shingles) and varicella (chickenpox) in patients requiring antiviral therapy, helping to reduce symptom severity and accelerate healing.

GNH India supplies Invirum as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Aflofarm Farmacja Polska Sp. Z O.O.

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Indications & Clinical Uses

  • Aciclovir is used to manage infections caused by herpesviruses.
  • Herpes simplex virus infections: reduces lesion duration and severity in oral and genital outbreaks.
  • Herpes zoster (shingles): alleviates pain and accelerates lesion healing in adults.
  • Varicella (chickenpox): shortens disease course in children and adults.

How It Works

  • Aciclovir is selectively taken up by infected cells and phosphorylated by viral thymidine kinase to aciclovir monophosphate, then further converted to the active triphosphate form. The triphosphate competitively inhibits viral DNA polymerase, halting viral DNA synthesis and replication while having minimal effect on host cellular DNA processes.

Side Effects

Aciclovir may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Nausea
  • Headache
  • Diarrhea
  • Fatigue
  • Dizziness
  • Abdominal discomfort

Serious or Rare Side Effects

  • Acute renal impairment
  • Severe allergic reactions (e.g., anaphylaxis)
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Bone marrow suppression
  • Seizures
  • Hepatitis

Precautions & Warnings

  • Before initiating therapy, certain precautions should be considered.
  • Renal function: adjust dose in patients with impaired renal function.
  • Hydration: maintain adequate fluid intake during treatment.
  • Pregnancy: use only if the potential benefit justifies the potential risk to the fetus.
  • Concurrent nephrotoxic drugs: monitor kidney function closely.
  • Allergy: discontinue if signs of hypersensitivity appear.
  • Store at ambient temperature: keep in the original container, protect from moisture and heat.

Avoid Interactions

Aciclovir can interact with other medicines, affecting its safety or effectiveness.

Major Interactions (Avoid)

  • Probenecid: increases aciclovir plasma concentrations, raising toxicity risk.
  • Cimetidine: reduces renal clearance, potentially leading to accumulation.
  • Nephrotoxic agents (e.g., aminoglycosides): heighten risk of renal damage.

Moderate Interactions (Monitor Closely)

  • Warfarin: may alter INR; monitor coagulation parameters.
  • Immunosuppressants (e.g., cyclosporine): increased infection susceptibility; observe clinical response.
  • Oral contraceptives: may reduce efficacy; advise additional contraceptive measures.

Frequently Asked Questions

Invirum contains the antiviral aciclovir and is indicated for the treatment of infections caused by herpesviruses, specifically herpes simplex virus (oral and genital lesions), herpes zoster (shingles), and varicella (chickenpox). It helps to reduce the severity and duration of these viral illnesses.

Aciclovir is taken up preferentially by virus‑infected cells, where viral thymidine kinase converts it to aciclovir monophosphate. Subsequent cellular kinases produce the active triphosphate, which competitively inhibits viral DNA polymerase, blocking viral DNA synthesis while sparing normal host cells.

The dose of Invirum is determined by the prescribing clinician based on the specific infection, patient age, renal function, and other clinical factors. Healthcare professionals adjust the regimen to achieve optimal antiviral effect while minimizing risk.

Data on aciclovir use in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and only under medical supervision.

To order Invirum, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Invirum (aciclovir) is a first‑generation antiviral with a well‑established safety profile. Compared with newer agents such as valacyclovir or famciclovir, aciclovir may require more frequent dosing but is effective for the same herpesvirus infections and is often less expensive.

Invirum should be stored at ambient temperature, below 25 °C. Keep the product in its original packaging, protect it from moisture and direct heat, and ensure the container is tightly closed to maintain stability.

Invirum is administered orally. The tablets (or oral formulation) should be swallowed whole with a glass of water and can be taken with or without food, unless otherwise directed by a healthcare professional.

Serious adverse events, although rare, include acute renal impairment, severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome or toxic epidermal necrolysis, bone‑marrow suppression, seizures, and hepatitis. Patients should seek immediate medical attention if any of these occur.

Invirum should be avoided in individuals with known hypersensitivity to aciclovir or any component of the formulation. Patients with severe renal impairment may require dose adjustment or alternative therapy, and those with a history of serious allergic reactions should consult a physician before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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