Product image of Invita D3 (Colecalciferol) supplied by GNH India

Invita D3

Active Ingredient:
Colecalciferol
Origin:
EU

Invita D3 (Colecalciferol)

Colecalciferol, the active ingredient in Invita D3, is a vitamin D presented as an oral tablet for oral use. It treats vitamin D deficiency and supports bone health in both adults and children by improving calcium and phosphate absorption.
GNH India supplies Invita D3 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Consilient Health Ltd

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Indications & Clinical Uses

Invita D3 (colecalciferol) is used to address conditions related to vitamin D deficiency and bone metabolism.

  • Vitamin D deficiency: restores adequate serum 25‑hydroxyvitamin D concentrations.
  • Osteoporosis: supports maintenance of bone mineral density and reduces fracture risk.
  • Rickets (children): promotes proper bone growth and mineralisation.
  • Secondary hyperparathyroidism: assists in normalising calcium balance.

How It Works

  • Colecalciferol is converted in the liver to 25‑hydroxyvitamin D and subsequently in the kidney to the active hormone 1,25‑dihydroxyvitamin D. The active form binds to intracellular vitamin D receptors, forming a complex that regulates gene transcription, thereby enhancing intestinal absorption of calcium and phosphate and facilitating bone mineralisation.

Side Effects

Adverse reactions to oral colecalciferol are generally uncommon but can occur.

Common Side Effects

  • Hypercalcaemia: elevated blood calcium levels causing nausea or weakness.
  • Hypercalciuria: increased urinary calcium excretion.
  • Gastrointestinal discomfort: mild stomach upset or constipation.
  • Headache: occasional mild headache.
  • Fatigue: transient tiredness.

Serious or Rare Side Effects

  • Severe hypercalcaemia: may lead to cardiac arrhythmia or renal impairment.
  • Allergic reaction: rash, itching, or swelling of the face, lips, or tongue.
  • Kidney stones: due to prolonged high calcium levels.
  • Hypervitaminosis D: excessive vitamin D accumulation causing systemic toxicity.

Precautions & Warnings

Before using Invita D3, consider the following safety measures.

  • Renal impairment: monitor calcium levels closely.
  • Hypercalcaemia history: avoid high doses without supervision.
  • Sarcoidosis or granulomatous disease: risk of increased vitamin D activation.
  • Pregnancy or breastfeeding: consult a healthcare professional before use.
  • Elderly patients: start with lower doses and adjust as needed.
  • Store below 25°C: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Colecalciferol may interact with several medicines, altering its effectiveness or safety.

Major Interactions (Avoid)

  • Thiazide diuretics: increase risk of hypercalcaemia.
  • Vitamin A excess: may potentiate toxicity.
  • Lithium: can raise calcium levels.

Moderate Interactions (Monitor Closely)

  • Anticonvulsants (e.g., phenytoin, phenobarbital): may reduce vitamin D activation.
  • Glucocorticoids: can impair vitamin D metabolism.
  • Orlistat: may decrease absorption of fat‑soluble vitamins.

Frequently Asked Questions

Invita D3 contains colecalciferol, a form of vitamin D, and is used to treat vitamin D deficiency, support bone health, and manage conditions such as osteoporosis, rickets, and secondary hyperparathyroidism by improving calcium and phosphate absorption.

Colecalciferol is converted first in the liver to 25‑hydroxyvitamin D and then in the kidney to the active hormone 1,25‑dihydroxyvitamin D. This active form binds to vitamin D receptors, regulating genes that increase intestinal calcium and phosphate uptake, essential for bone mineralisation.

The appropriate dose of Invita D3 is determined by a qualified healthcare professional based on the individual’s serum vitamin D level, age, weight, and clinical condition. Patients should follow the prescriber’s instructions and not self‑adjust the dosage.

Pregnant or breastfeeding individuals should only use Invita D3 if advised by their healthcare provider. Vitamin D is important for fetal development, but dosing must be carefully managed to avoid excess calcium levels that could affect both mother and child.

To order Invita D3, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and necessary import documentation.

Invita D3 provides colecalciferol, the same active ingredient found in many vitamin D supplements. Compared with ergocalciferol (vitamin D2), colecalciferol generally has a longer half‑life and may achieve more stable serum levels, making it a preferred choice for long‑term supplementation.

Invita D3 should be stored below 25 °C in its original packaging, protected from moisture and direct sunlight. Keeping the tablets in a cool, dry place helps maintain potency throughout the shelf‑life.

Invita D3 is taken orally, typically with water. It can be taken with or without food, but consistent administration with respect to meals helps maintain stable absorption. Patients should follow the dosing schedule prescribed by their clinician.

The most serious risks include severe hypercalcaemia, which can cause cardiac arrhythmias, kidney stones, or renal impairment, and rare allergic reactions such as anaphylaxis. Prompt medical attention is required if symptoms of high calcium or allergic response appear.

Individuals with known hypersensitivity to colecalciferol, those with uncontrolled hypercalcaemia, or patients with certain granulomatous diseases (e.g., sarcoidosis) should avoid using Invita D3 unless specifically directed by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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