Product image of Invitad3 (Colecalciferol) supplied by GNH India

Invitad3

Active Ingredient:
Colecalciferol
Origin:
EU

Invitad3 (Colecalciferol)

Colecalciferol, the active ingredient in Invitad3, is a Vitamin D (Colecalciferol) presented as an oral supplement for oral use. It is used to address vitamin D deficiency and to support bone health in individuals at risk of osteomalacia or rickets. By increasing intestinal absorption of calcium and phosphate, it promotes bone mineralization.

GNH India supplies Invitad3 as a licensed, GDP‑compliant international pharmaceutical supplier, providing the product to hospitals, pharmacies, transplant centres and clinics across global markets, ensuring quality and regulatory compliance.

Manufacturer / TM Owner

Consilient Health Ltd

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Indications & Clinical Uses

Invitad3 (colecalciferol) is used in the vitamin D pathway to correct deficiency and maintain skeletal health.

  • Vitamin D deficiency: restores adequate serum 25‑hydroxyvitamin D levels.
  • Osteomalacia/rickets prevention: helps prevent the development of soft bone disease in at‑risk populations.
  • Bone health support: contributes to normal bone mineralization and calcium homeostasis.

How It Works

  • Colecalciferol is converted in the liver to 25‑hydroxyvitamin D, which is further hydroxylated in the kidney to the active hormone 1,25‑dihydroxyvitamin D. The active form binds to the vitamin D receptor in intestinal cells, enhancing transcription of calcium‑binding proteins and increasing absorption of calcium and phosphate, thereby facilitating bone mineralization. This process also regulates parathyroid hormone secretion and contributes to overall calcium balance.

Side Effects

Colecalciferol may cause adverse reactions, which are generally dose‑dependent and vary in frequency.

Common Side Effects

  • Hypercalcemia: elevated blood calcium levels causing nausea or fatigue.
  • Gastrointestinal discomfort: mild abdominal pain or constipation.
  • Headache: transient mild headache.

Serious or Rare Side Effects

  • Hypercalciuria: excessive urinary calcium excretion leading to kidney stones.
  • Allergic reactions: rash, itching, or swelling of the face and throat.
  • Severe hypercalcemia: confusion, cardiac arrhythmias, or renal impairment.

Precautions & Warnings

When using Invitad3, consider the following precautions to ensure safe and effective therapy.

  • Assess baseline vitamin D status: measure serum 25‑hydroxyvitamin D before initiating therapy.
  • Monitor calcium levels: periodic testing is advised, especially in patients with renal disease.
  • Caution in hypercalcemia: avoid use in individuals with known high calcium concentrations.
  • Use with care in sarcoidosis or granulomatous diseases: these conditions may increase active vitamin D production.
  • Pregnancy and lactation: consult a healthcare professional before use, as safety data are limited.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Colecalciferol can interact with several medicines, affecting its absorption or metabolism.

Major Interactions (Avoid)

  • Thiazide diuretics: may increase risk of hypercalcemia.
  • Vitamin A excess: combined high doses can lead to hypercalcemia.
  • Calcium supplements: concurrent high doses can cause elevated calcium levels.

Moderate Interactions (Monitor Closely)

  • Anticonvulsants (e.g., phenobarbital, phenytoin): may enhance vitamin D metabolism, reducing effectiveness.
  • Glucocorticoids: can impair vitamin D activation and increase bone loss.
  • Orlistat: may decrease absorption of fat‑soluble vitamins including vitamin D.

Frequently Asked Questions

Invitad3 contains colecalciferol, a form of vitamin D, and is used to treat vitamin D deficiency, help prevent osteomalacia or rickets, and support normal bone health by ensuring adequate calcium and phosphate absorption.

Colecalciferol is converted in the liver and kidneys to the active hormone 1,25‑dihydroxyvitamin D, which binds to vitamin D receptors in the intestine, increasing the synthesis of calcium‑binding proteins and enhancing calcium and phosphate absorption for bone mineralization.

The appropriate dose of Invitad3 is determined by a qualified healthcare professional based on the patient’s serum vitamin D level, age, weight, and clinical condition. The prescriber will set the exact regimen.

Safety data for colecalciferol during pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss the use of Invitad3 with their healthcare provider to weigh potential benefits and risks.

To order Invitad3, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Invitad3 provides colecalciferol, the natural form of vitamin D3, which is generally considered more potent and longer‑acting than vitamin D2 (ergocalciferol). It is comparable to other vitamin D3 supplements but may differ in dosage strength, formulation and regulatory status.

Invitad3 should be stored at room temperature, below 25 °C, in its original packaging. Keep the container tightly closed, protect it from moisture and direct sunlight, and keep it out of reach of children.

Invitad3 is taken orally, usually with or without food, as directed by a healthcare professional. The tablet or capsule should be swallowed whole with a glass of water unless otherwise instructed.

The most serious risks include hypercalcemia and hypercalciuria, which can lead to kidney stones, cardiac arrhythmias, or renal impairment. Patients should be monitored for symptoms such as nausea, vomiting, confusion, or excessive thirst.

Invitad3 should be avoided in individuals with known hypercalcemia, severe renal impairment, or those taking high doses of calcium or vitamin A without medical supervision. Patients with sarcoidosis or other granulomatous diseases should use it only under close medical guidance.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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