Product image of Inzamoda (Enzalutamide) supplied by GNH India

Inzamoda

Active Ingredient:
Enzalutamide
Origin:
EU

Inzamoda (Enzalutamide)

Enzalutamide, the active ingredient in Inzamoda, is a nonsteroidal antiandrogen presented as a tablet for oral use. It is indicated for the treatment of metastatic castration‑resistant prostate cancer and non‑metastatic castration‑resistant prostate cancer in adult males who have progressed despite hormonal therapy.

GNH India supplies Inzamoda as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide. The company adheres to strict quality standards and provides reliable logistics for global distribution to clinical sites and retail pharmacies.

Manufacturer / TM Owner

Innovis Pharma

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Indications & Clinical Uses

  • Enzalutamide is used in the hormonal therapy pathway for prostate cancer.
  • Metastatic castration‑resistant prostate cancer: improves overall survival and delays disease progression.
  • Non‑metastatic castration‑resistant prostate cancer: delays metastasis and extends metastasis‑free survival.
  • Castration‑resistant prostate cancer (general): provides androgen‑receptor blockade when disease progresses despite androgen deprivation therapy.

How It Works

  • Enzalutamide acts as a high‑affinity androgen‑receptor antagonist. It blocks androgen binding, prevents receptor translocation to the nucleus, inhibits DNA binding and blocks recruitment of co‑activators, thereby suppressing androgen‑driven transcription and tumor growth in prostate cancer cells.

Side Effects

Adverse reactions may occur with Enzalutamide therapy.

Common Side Effects

  • Fatigue: persistent tiredness reported by many patients.
  • Hot flashes: sudden feeling of warmth and sweating.
  • Hypertension: elevated blood pressure requiring monitoring.
  • Diarrhea: loose stools that may affect hydration.
  • Nausea: mild to moderate upset stomach.
  • Decreased appetite: reduced desire to eat.

Serious or Rare Side Effects

  • Seizures: rare but potentially life‑threatening events.
  • Severe hypertension: markedly high blood pressure needing urgent care.
  • Hepatic injury: elevated liver enzymes or hepatitis.
  • Interstitial lung disease: inflammation of lung tissue.
  • Allergic reactions: rash, angioedema, or anaphylaxis.

Precautions & Warnings

  • Before initiating therapy, clinicians should consider several safety measures.
  • Monitor blood pressure: check regularly due to risk of hypertension.
  • Assess seizure history: avoid in patients with prior seizures.
  • Evaluate hepatic function: monitor liver enzymes during treatment.
  • Avoid strong CYP2C8 inhibitors: may increase enzalutamide exposure.
  • Store at ambient temperature: keep below 25°C in the original pack, protect from moisture.

Avoid Interactions

Enzalutamide may interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Strong CYP2C8 inhibitors (e.g., gemfibrozil): may raise enzalutamide plasma levels.
  • Strong CYP3A4 inducers (e.g., rifampin): may reduce therapeutic effect.

Moderate Interactions (Monitor Closely)

  • CYP2C9 substrates (e.g., warfarin): may alter anticoagulant activity.
  • Anticoagulants (e.g., apixaban, rivaroxaban): monitor for bleeding.
  • Other antiandrogens (e.g., bicalutamide): may increase toxicity risk.

Frequently Asked Questions

Inzamoda contains enzalutamide and is prescribed for adult males with metastatic or non‑metastatic castration‑resistant prostate cancer. It works as part of hormonal therapy to block androgen signaling, helping to slow tumor growth and extend survival when disease has progressed despite standard androgen‑deprivation therapy.

Enzalutamide is an androgen‑receptor antagonist. It binds to the receptor with high affinity, blocks androgen binding, prevents the receptor from moving into the cell nucleus, and stops DNA binding and co‑activator recruitment. This disrupts androgen‑driven gene transcription that fuels prostate‑cancer cell proliferation.

The dosing regimen for Inzamoda is determined by the prescribing clinician based on the patient’s clinical status, renal and hepatic function, and concomitant medications. Physicians follow approved labeling and adjust the dose as needed; patients should follow the exact instructions provided by their healthcare professional.

Enzalutamide is classified as pregnancy category unknown and is not recommended for use during pregnancy or lactation. Because it may affect fetal development and can be excreted in breast milk, women of child‑bearing potential should use effective contraception and discuss risks with their physician.

To request Inzamoda, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Inzamoda (enzalutamide) is a second‑generation nonsteroidal antiandrogen with higher affinity for the androgen receptor than older agents such as bicalutamide. Compared with alternatives like apalutamide or darolutamide, enzalutamide has a well‑established efficacy profile but may carry a higher risk of seizures, requiring individual risk assessment.

Store Inzamoda tablets at ambient temperature, preferably below 25 °C. Keep the product in its original container, protect it from moisture and direct sunlight, and ensure the packaging remains sealed until use. Do not store in a refrigerator or freezer.

Inzamoda is taken orally as a tablet. It can be swallowed whole with water, with or without food, as directed by the prescriber. Patients should not crush, split, or chew the tablet unless specifically instructed, to maintain consistent drug absorption.

The most serious adverse events associated with Inzamoda include seizures, severe hypertension, and hepatic injury. Patients should be educated to report any new seizure activity, sudden increases in blood pressure, jaundice, or unexplained abdominal pain promptly so that appropriate medical evaluation can be performed.

Inzamoda is contraindicated in patients with a known history of seizures, uncontrolled hypertension, or severe hepatic impairment. It should also be avoided in individuals taking strong CYP2C8 inhibitors or in those with hypersensitivity to enzalutamide or any tablet excipients.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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