Product image of Iodopol (Sodium Iodide (131i)) supplied by GNH India

Iodopol

Active Ingredient:
Sodium Iodide (131i)
Origin:
EU

Iodopol (Sodium Iodide (131i))

Sodium Iodide, the active ingredient in Iodopol, is a radioactive iodine presented as a radiopharmaceutical for oral use. It is employed in the management of thyroid cancer, hyperthyroidism ablation, and thyroid imaging in adult patients.
GNH India supplies Iodopol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Narodowe Centrum Badań Jądrowych

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Indications & Clinical Uses

Iodopol is used in the radioactive iodine pathway to diagnose and treat thyroid‑related conditions.

  • Thyroid cancer treatment: delivers targeted beta radiation to destroy malignant thyroid tissue.
  • Hyperthyroidism (thyroid ablation): ablates overactive thyroid cells to restore normal hormone levels.
  • Thyroid imaging and diagnostic scans: provides gamma emission for high‑resolution scintigraphy and whole‑body scans.

How It Works

  • Sodium Iodide-131 is selectively taken up by thyroid follicular cells via the sodium‑iodide symporter. Once internalized, the isotope emits beta particles that cause localized cellular destruction and gamma photons that enable external imaging, allowing both therapeutic ablation and diagnostic visualization of thyroid tissue.

Side Effects

Adverse reactions may occur following oral administration of radioactive iodine.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Dry mouth: reduced salivary flow.
  • Taste alteration: metallic or bitter sensation.
  • Transient thyroid pain: mild discomfort in the neck region.
  • Mild leukopenia: temporary reduction in white blood cells.
  • Fatigue: short‑term tiredness.

Serious or Rare Side Effects

  • Severe radiation thyroiditis: intense inflammation of the thyroid gland.
  • Bone marrow suppression: prolonged pancytopenia requiring monitoring.
  • Allergic reaction: rash, pruritus, or anaphylaxis in rare cases.
  • Pulmonary fibrosis: rare radiation‑induced lung injury.
  • Secondary malignancy: potential long‑term risk of new cancers.
  • Salivary gland dysfunction: persistent xerostomia.

Precautions & Warnings

Prior assessment and ongoing monitoring are essential when using Iodopol.

  • Baseline thyroid function: obtain serum TSH, T3, and T4 before therapy.
  • Blood count monitoring: perform complete blood counts during and after treatment.
  • Pregnancy avoidance: do not administer to pregnant women unless benefits outweigh risks.
  • Lactation caution: advise breastfeeding cessation during therapy.
  • Concomitant medication review: evaluate for drugs that affect iodine uptake.
  • Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Iodopol may interact with other agents that influence thyroid function or radiation response.

Major Interactions (Avoid)

  • Lithium: potentiates thyroid dysfunction and may alter iodine uptake.
  • Antithyroid drugs (e.g., methimazole, propylthiouracil): reduce therapeutic efficacy.
  • Amiodarone: high iodine content interferes with radioiodine distribution.

Moderate Interactions (Monitor Closely)

  • Levothyroxine: adjust dose based on thyroid function tests.
  • Anticoagulants (e.g., warfarin): monitor INR for radiation‑induced changes.
  • Diuretics: assess electrolyte balance during therapy.
  • Beta‑blockers: may mask symptoms of thyroid storm.

Frequently Asked Questions

Iodopol contains sodium iodide‑131 and is used to treat thyroid cancer, ablate hyperactive thyroid tissue in hyperthyroidism, and perform diagnostic imaging of the thyroid gland through gamma emission.

Sodium iodide‑131 is taken up by thyroid cells via the sodium‑iodide symporter. The isotope emits beta particles that destroy targeted thyroid tissue and gamma photons that allow external imaging, providing both therapeutic and diagnostic capabilities.

The prescribed dose of Iodopol is determined by the treating physician based on the specific indication, patient weight, thyroid uptake studies, and clinical guidelines. Dosing regimens are individualized and not standardized.

Iodopol is generally contraindicated in pregnancy because radioactive iodine can affect the developing fetal thyroid. Breastfeeding should be discontinued during and after treatment, as the isotope can be secreted in milk.

To order Iodopol, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and required import documentation.

Iodopol provides the same iodine‑131 isotope as other branded radiopharmaceuticals but is supplied as a GMP‑compliant oral preparation from the EU market. Clinical efficacy and safety are comparable, while pricing and supply logistics may differ.

Iodopol should be stored at temperatures below 25 °C, in its original container, protected from moisture and direct sunlight. It must be handled by qualified personnel using appropriate radiation safety measures.

Iodopol is administered orally as a single dose or series of doses, as directed by the prescribing physician. The patient may be instructed to fast before ingestion and to avoid certain foods that interfere with iodine uptake.

Serious risks include severe radiation thyroiditis, bone marrow suppression leading to pancytopenia, allergic reactions, pulmonary fibrosis, and the long‑term possibility of secondary malignancies. Patients are monitored closely for these events.

Iodopol should not be used in pregnant women, nursing mothers, patients with severe iodine allergy, or individuals with uncontrolled thyroid disorders without prior specialist evaluation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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