Product image of Iodopol (Sodium Iodide (131i)) supplied by GNH India

Iodopol

Active Ingredient:
Sodium Iodide (131i)
Origin:
EU

Iodopol (Sodium Iodide (131i))

Sodium Iodide, the active ingredient in Iodopol, is a radioactive iodine presented as a radiopharmaceutical for oral use. It is employed in diagnostic imaging and therapeutic procedures that target thyroid tissue in patients with thyroid disorders. The I‑131 isotope emits beta particles for tissue ablation and gamma radiation for imaging, enabling both treatment and functional assessment of the thyroid gland.

GNH India supplies Iodopol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Narodowe Centrum Badań Jądrowych

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Indications & Clinical Uses

Iodopol is used in the management of thyroid conditions where radioactive iodine uptake is required.

  • Thyroid cancer: ablation of residual thyroid tissue after thyroidectomy.
  • Hyperthyroidism (Graves disease, toxic nodular goitre): reduction of excess thyroid hormone production.
  • Diagnostic thyroid scan: imaging of thyroid function and iodine uptake for assessment.

How It Works

  • After oral administration, I‑131 sodium iodide is actively transported into thyroid cells via the sodium‑iodide symporter. Within the gland, the isotope emits beta particles that cause localized cellular damage, leading to tissue ablation, while emitted gamma photons allow external imaging of thyroid uptake and function.

Side Effects

Iodopol may cause a range of adverse reactions.

Common Side Effects

  • Nausea or vomiting.
  • Dry mouth or altered taste sensation.
  • Mild neck discomfort or thyroid tenderness.
  • Transient hypothyroidism.

Serious or Rare Side Effects

  • Radiation thyroiditis.
  • Severe or permanent hypothyroidism requiring hormone replacement.
  • Bone marrow suppression leading to cytopenias.
  • Allergic reactions such as rash or anaphylaxis.
  • Development of secondary malignancies due to radiation exposure.

Precautions & Warnings

Use of Iodopol requires careful consideration of several safety aspects.

  • Pregnancy: avoid unless clearly indicated, as fetal radiation exposure can be harmful.
  • Breastfeeding: discontinue treatment; iodine-131 can be secreted in breast milk.
  • Thyroid function monitoring: assess hormone levels before and after therapy.
  • Radiation safety: implement protective measures for patients, caregivers, and healthcare staff.
  • Contraindications: known iodine allergy or severe uncontrolled thyroid disease.
  • Store at ambient temperature below 25°C: keep in the original container, protect from moisture and light.

Avoid Interactions

Iodopol can interact with other medications that affect iodine metabolism or radiation response.

Major Interactions (Avoid)

  • Lithium: increases iodine uptake and may exacerbate toxicity.
  • Antithyroid drugs (propylthiouracil, methimazole): reduce the efficacy of radioactive iodine.
  • Amiodarone: high iodine load interferes with treatment outcomes.
  • Other iodine‑131 radiopharmaceuticals: cumulative radiation dose may become excessive.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: potential impact on renal clearance of iodine.
  • Diuretics: may alter iodine excretion rates.
  • Chemotherapy agents: combined bone marrow suppression risk requires monitoring.

Frequently Asked Questions

Iodopol is a radioactive iodine (I‑131) preparation used for both diagnostic imaging of thyroid function and therapeutic ablation of thyroid tissue in conditions such as thyroid cancer and hyperthyroidism. It enables clinicians to visualize iodine uptake and deliver targeted radiation to diseased thyroid cells.

Sodium Iodide (I‑131) is taken up by thyroid cells via the sodium‑iodide symporter. Once inside the gland, the isotope emits beta particles that destroy thyroid tissue and gamma photons that can be detected by imaging equipment, providing both therapeutic and diagnostic capabilities.

The dose of Iodopol is individualized and determined by the prescribing physician based on the specific indication, patient characteristics, and desired therapeutic effect. Dosing is calculated in megabecquerels (MBq) and administered under controlled conditions.

Iodopol is generally contraindicated in pregnancy because the radioactive iodine can affect fetal thyroid development. Breastfeeding should be discontinued during treatment, as iodine‑131 can be secreted in breast milk and expose the infant to radiation.

To order Iodopol, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details and necessary import documentation.

Iodopol contains the same I‑131 isotope used in other branded or generic radioactive iodine preparations. Differences may lie in formulation, regulatory approvals, and supply chain logistics. Clinicians choose a product based on availability, regulatory status, and institutional preferences.

Iodopol should be stored at ambient temperature below 25 °C in its original packaging, protected from moisture and light. As a radiopharmaceutical, it must be handled in accordance with radiation safety guidelines, using appropriate shielding and monitoring.

Iodopol is administered orally as a single dose in a capsule or liquid form, depending on the product presentation. The patient swallows the dose under medical supervision, and subsequent imaging or follow‑up is performed as directed by the treating physician.

Serious risks include radiation thyroiditis, severe or permanent hypothyroidism requiring lifelong hormone replacement, bone marrow suppression leading to cytopenias, allergic reactions, and the rare possibility of secondary malignancies due to radiation exposure.

Iodopol should not be used in patients who are pregnant, breastfeeding, have a known allergy to iodine, or have uncontrolled thyroid disease where radioactive iodine therapy is contraindicated. Physicians must evaluate each patient’s medical history before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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