Product image of Iodopol (Sodium Iodide (131i)) supplied by GNH India

Iodopol

Active Ingredient:
Sodium Iodide (131i)
Origin:
EU

Iodopol (Sodium Iodide (131i))

Sodium Iodide, the active ingredient in Iodopol, is a Radioactive iodine presented as an oral preparation for oral use. It is employed in the treatment of thyroid cancer, hyperthyroidism and for thyroid ablation in patients requiring reduction of thyroid tissue activity.
GNH India supplies Iodopol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Narodowe Centrum Badań Jądrowych

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Indications & Clinical Uses

Iodopol delivers radioactive iodine to thyroid tissue, making it useful for several thyroid‑related conditions.

  • Thyroid cancer: facilitates targeted destruction of malignant thyroid cells.
  • Hyperthyroidism: reduces excess hormone production by ablating overactive thyroid tissue.
  • Thyroid ablation: prepares patients for subsequent thyroid hormone replacement by eliminating residual thyroid tissue.

How It Works

  • Sodium Iodide (I‑131) is selectively taken up by thyroid follicular cells via the sodium‑iodide symporter. Once inside the gland, the beta emissions from I‑131 deliver localized radiation that damages cellular DNA, leading to apoptosis of hyperactive or malignant thyroid cells while sparing surrounding tissues.

Side Effects

Iodopol may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: mild gastrointestinal upset after ingestion.
  • Dry mouth: reduced salivary flow.
  • Neck tenderness: localized discomfort in the thyroid region.
  • Fatigue: transient feeling of tiredness.
  • Transient hypothyroidism: temporary reduction in thyroid hormone levels.

Serious or Rare Side Effects

  • Radiation thyroiditis: painful inflammation of the thyroid gland.
  • Salivary gland dysfunction: persistent dry mouth or swelling.
  • Bone marrow suppression: decreased blood cell counts.
  • Secondary malignancies: rare risk of other cancers due to radiation exposure.
  • Allergic reaction: rash, itching, or swelling at the site of administration.

Precautions & Warnings

Before prescribing Iodopol, clinicians should consider several safety measures.

  • Pregnancy: avoid use unless clearly needed, as fetal thyroid can be affected.
  • Breastfeeding: discontinue breastfeeding during treatment and for a period afterward.
  • Renal impairment: adjust dose or monitor closely due to altered iodine clearance.
  • Pre‑existing thyroiditis: assess risk of exacerbated inflammation.
  • Concomitant radiation therapy: coordinate to prevent overlapping radiation doses.

Store at below 25°C: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Iodopol can interact with other medications, influencing its efficacy or safety.

Major Interactions (Avoid)

  • Antithyroid drugs (e.g., methimazole, propylthiouracil): may reduce iodine uptake.
  • Lithium: can impair thyroid hormone release and alter treatment response.

Moderate Interactions (Monitor Closely)

  • Amiodarone: high iodine content may affect thyroid function.
  • Corticosteroids: may lessen radiation‑induced thyroiditis but require monitoring.
  • Diuretics: can alter renal iodine excretion, affecting dosing considerations.

Frequently Asked Questions

Iodopol is used in the management of thyroid cancer, hyperthyroidism, and for thyroid ablation procedures. It delivers radioactive iodine directly to thyroid tissue, helping to destroy malignant or overactive cells while preserving surrounding structures.

Sodium Iodide (I‑131) is taken up by thyroid cells via the sodium‑iodide symporter. Inside the cells, the beta radiation emitted by I‑131 damages DNA, leading to cell death. This targeted approach reduces or eliminates hyperactive or cancerous thyroid tissue.

The dose of Iodopol is individualized and determined by the prescribing physician based on the specific indication, disease severity, patient weight, and prior treatments. Dosage regimens are not standardized and should follow the clinician’s assessment.

Iodopol is generally contraindicated in pregnancy because radioactive iodine can affect fetal thyroid development. Breastfeeding should be discontinued during treatment and for a period afterward to avoid iodine transfer to the infant. Physicians must weigh risks and benefits before prescribing.

To order Iodopol, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials. The team then provides pricing, availability, shipping details (including any cold‑chain requirements) and assists with import documentation.

Iodopol contains Sodium Iodide (I‑131) similar to other I‑131 preparations, but formulation differences (e.g., tablet versus capsule) may affect handling and patient preference. Clinical efficacy is comparable when appropriate dosing is used, while safety profiles depend on individual patient factors and administration protocols.

Iodopol should be stored at temperatures below 25 °C, in its original packaging, protected from moisture and direct sunlight. Maintaining these conditions preserves the stability of the radioactive iodine and ensures accurate dosing.

Iodopol is taken orally as a single dose or series of doses, as directed by the treating physician. The tablet is swallowed with water, typically on an empty stomach to maximize thyroid uptake of the radioactive iodine.

Serious risks include radiation thyroiditis, salivary gland dysfunction, bone marrow suppression, and the rare possibility of secondary malignancies. Patients should be monitored for signs of severe inflammation, blood count changes, and any unexpected symptoms.

Iodopol is contraindicated in pregnant women, nursing mothers, and patients with severe iodine allergy. Individuals with uncontrolled thyroiditis or those receiving conflicting radiation therapy should also avoid its use unless a specialist determines it is safe.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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