Product image of Iodopol (Sodium Iodide (131i)) supplied by GNH India

Iodopol

Active Ingredient:
Sodium Iodide (131i)
Origin:
EU

Iodopol (Sodium Iodide (131i))

Sodium Iodide (131I), the active ingredient in Iodopol, is a radioactive iodine (radiopharmaceutical) presented as a radiopharmaceutical for oral use. It is employed to target thyroid tissue for both therapeutic ablation and diagnostic imaging in patients with thyroid disorders.

GNH India supplies Iodopol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide, adhering to stringent quality standards and providing reliable global distribution.

Manufacturer / TM Owner

Narodowe Centrum Badań Jądrowych

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Indications & Clinical Uses

Iodopol is used in the management of thyroid‑related conditions, providing both therapeutic and diagnostic capabilities.

  • Thyroid cancer: facilitates postoperative ablation of residual thyroid tissue and metastatic disease.
  • Hyperthyroidism: reduces hormone production by selectively destroying overactive thyroid cells.
  • Thyroid ablation: prepares patients for radioactive iodine therapy by eliminating functional thyroid tissue.
  • Diagnostic imaging of thyroid: enables scintigraphic visualization of thyroid uptake for functional assessment.

How It Works

  • Sodium Iodide (131I) is taken up by thyroid follicular cells via the sodium‑iodide symporter. Once inside the gland, the radioactive iodine emits beta particles that deliver localized radiation, destroying thyroid tissue while sparing surrounding structures. The same uptake allows gamma emission to be captured for diagnostic scintigraphy, providing both therapeutic and imaging functions.

Side Effects

Iodopol may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea or vomiting.
  • Metallic taste in the mouth.
  • Sore throat or mild neck discomfort.
  • Transient hypothyroidism.
  • Mild fatigue.
  • Temporary increase in thyroid pain.

Serious or Rare Side Effects

  • Aplastic anemia or severe bone‑marrow suppression.
  • Radiation‑induced thyroiditis.
  • Pulmonary fibrosis.
  • Allergic or anaphylactic reaction.
  • Secondary malignancies due to radiation exposure.
  • Severe hypothyroidism requiring lifelong hormone replacement.

Precautions & Warnings

When prescribing Iodopol, clinicians should observe several safety measures to minimize risk.

  • Pregnancy: avoid use unless benefits outweigh risks, as fetal thyroid may be affected.
  • Breastfeeding: discontinue breastfeeding before administration; iodine can be secreted in milk.
  • Renal impairment: adjust dose or monitor closely due to reduced clearance.
  • Thyroid function: assess baseline status and monitor post‑treatment.
  • Concomitant iodine: avoid other iodine‑containing drugs that may interfere with uptake.
  • Store below 25°C: keep in original container, protect from moisture and light.

Avoid Interactions

Iodopol can interact with other agents that influence iodine metabolism or radiation sensitivity.

Major Interactions (Avoid)

  • Antithyroid drugs (e.g., propylthiouracil, methimazole): block iodine uptake.
  • Lithium: impairs thyroid hormone release, altering treatment effect.
  • Amiodarone: high iodine load may reduce efficacy.

Moderate Interactions (Monitor Closely)

  • Radioactive contrast agents: compete for iodine uptake.
  • Corticosteroids: may reduce radiation‑induced inflammation.
  • Chemotherapeutic agents affecting bone marrow: increase risk of hematologic toxicity.

Frequently Asked Questions

Iodopol is a radioactive iodine preparation used to treat thyroid cancer, manage hyperthyroidism, perform thyroid ablation before definitive therapy, and provide diagnostic imaging of thyroid function. It delivers targeted radiation to thyroid cells, allowing both therapeutic destruction and scintigraphic assessment.

Sodium Iodide (131I) is actively taken up by thyroid follicular cells via the sodium‑iodide symporter. Inside the gland, the isotope emits beta particles that destroy thyroid tissue, while gamma emissions can be captured for imaging. This dual action enables both treatment of disease and visualization of thyroid uptake.

The prescribed dose of Iodopol is individualized by the treating physician based on the specific indication, patient weight, thyroid uptake studies, and clinical goals. Dosage calculations follow established nuclear medicine protocols and are not standardized across all patients.

Iodopol is generally contraindicated in pregnancy because the radioactive iodine can affect the developing fetal thyroid. Breastfeeding should be discontinued before administration, as iodine can be secreted in milk and expose the infant to radiation. Consultation with a specialist is essential.

To order Iodopol, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Iodopol contains Sodium Iodide (131I), the same isotope used in other commercial radioactive iodine products. Differences may lie in formulation, regulatory approvals, and supply chain reliability. Clinically, the therapeutic and diagnostic effects are comparable when administered at equivalent activity levels.

Iodopol should be stored below 25 °C in its original packaging, protected from moisture and light. The product must be kept out of reach of unauthorized personnel, and any handling should follow radiopharmacy safety guidelines to prevent contamination or accidental exposure.

Iodopol is administered orally as a single dose under the supervision of a qualified nuclear medicine specialist. The patient typically ingests the preparation with water after fasting, and thyroid uptake is monitored using scintigraphy to assess distribution and therapeutic effect.

Serious risks include bone‑marrow suppression (e.g., aplastic anemia), severe radiation thyroiditis, pulmonary fibrosis, allergic reactions, and the potential for secondary malignancies due to radiation exposure. Patients should be monitored closely for hematologic changes and thyroid function after treatment.

Iodopol is contraindicated in pregnant women, nursing mothers, patients with severe renal impairment who cannot clear the isotope, and individuals with known hypersensitivity to iodine or radioactive substances. It should also be avoided in patients receiving high‑dose antithyroid medications that block iodine uptake.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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