Product image of Iodopol (Sodium Iodide (131i)) supplied by GNH India

Iodopol

Active Ingredient:
Sodium Iodide (131i)
Origin:
EU

Iodopol (Sodium Iodide (131i))

Sodium Iodide, the active ingredient in Iodopol, is a radioactive iodine compound presented as an oral solution for oral use. It is employed in the diagnosis and treatment of thyroid disorders, including cancer and hyperfunctioning conditions.

GNH India supplies Iodopol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide, ensuring quality, regulatory compliance and reliable delivery across global markets. The product meets European Union pharmacopeia standards and is manufactured under strict GMP conditions.

Manufacturer / TM Owner

Narodowe Centrum Badań Jądrowych

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Indications & Clinical Uses

Iodopol, containing sodium iodide‑131, is used in therapeutic and diagnostic pathways related to thyroid tissue.

  • Thyroid cancer: facilitates ablation of residual thyroid tissue after thyroidectomy.
  • Hyperthyroidism: reduces hormone production by delivering targeted radiation to overactive thyroid cells.
  • Thyroid imaging: enables visualization of functional thyroid tissue distribution for diagnostic assessment.
  • Thyroid nodules: assists in functional evaluation to differentiate benign from malignant lesions.
  • Metastatic thyroid cancer: helps detect iodine‑avid metastatic disease throughout the body.

How It Works

  • Sodium Iodide‑131 is actively transported into thyroid follicular cells via the sodium‑iodide symporter. Once inside, the beta particles emitted by the radionuclide cause localized cytotoxic damage to thyroid tissue, while the accompanying gamma photons permit external imaging. This selective uptake allows both therapeutic ablation of diseased thyroid cells and diagnostic visualization of iodine‑avid tissue. The radiation dose is confined largely to the gland, minimizing exposure to surrounding organs.

Side Effects

Sodium Iodide‑131 may be associated with a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Nausea: mild gastrointestinal upset occurring shortly after administration.
  • Dry mouth: reduced salivary flow leading to discomfort.
  • Taste alteration: transient metallic taste sensation.
  • Neck pain: mild discomfort in the thyroid region.
  • Transient hypothyroidism: temporary reduction in thyroid hormone levels.
  • Mild leukopenia: slight decrease in white blood cell count.

Serious or Rare Side Effects

  • Bone marrow suppression: significant reduction in blood cell production.
  • Severe hypothyroidism: prolonged deficiency requiring hormone replacement.
  • Allergic reaction: rash, itching, or anaphylaxis in rare cases.
  • Radiation thyroiditis: inflammation of the thyroid gland.
  • Pulmonary fibrosis: rare scarring of lung tissue following high cumulative doses.

Precautions & Warnings

When using Iodopol, several precautions should be observed to ensure safety and efficacy.

  • Pregnancy: avoid unless benefits outweigh risks, due to fetal radiation exposure.
  • Breastfeeding: contraindicated, as iodine‑131 can be secreted in milk.
  • Renal impairment: monitor renal function and adjust monitoring frequency.
  • Thyroid function: assess baseline thyroid status before therapy.
  • Radiation safety: follow strict handling and disposal protocols to protect staff and public.
  • Store at ambient temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Sodium Iodide‑131 can interact with certain medications and substances that affect iodine uptake or radiation response.

Major Interactions (Avoid)

  • Antithyroid drugs (propylthiouracil, methimazole): block iodine uptake, reducing efficacy.
  • Lithium: decreases thyroid uptake of iodine, diminishing therapeutic effect.
  • Amiodarone: high iodine content may interfere with radioiodine distribution.

Moderate Interactions (Monitor Closely)

  • Diuretics: may alter renal excretion of iodine‑131, requiring monitoring.
  • Chemotherapy agents: can increase risk of bone marrow suppression when combined.

Frequently Asked Questions

Iodopol contains sodium iodide‑131, a radioactive form of iodine that is used both diagnostically and therapeutically in thyroid‑related conditions. It helps visualize functional thyroid tissue during imaging studies and delivers targeted radiation to treat thyroid cancer, hyperthyroidism, and iodine‑avid metastatic disease.

Sodium iodide‑131 is taken up by thyroid cells through the sodium‑iodide symporter. Inside the cells, the emitted beta particles cause localized radiation damage that destroys overactive or malignant tissue, while the accompanying gamma emissions allow external imaging of iodine‑concentrating areas.

The specific dose of Iodopol is determined by the prescribing physician based on the patient’s clinical condition, thyroid function, and imaging results. Dosing is individualized and should follow the guidance of a qualified healthcare professional.

Iodopol is generally contraindicated during pregnancy because the radioactive iodine can cross the placenta and affect the fetal thyroid. It is also contraindicated while breastfeeding, as iodine‑131 can be secreted in breast milk and expose the infant to radiation.

To order Iodopol, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Iodopol delivers radioactive iodine directly to thyroid tissue, offering a non‑surgical option for ablation and imaging. Compared with non‑radioactive antithyroid drugs, it provides a one‑time or limited‑course treatment that can permanently reduce thyroid activity. Alternative radioiodine products contain the same isotope, but formulation differences may affect handling and dosing convenience.

Iodopol should be stored at ambient temperature, below 25 °C, in its original container. Protect the product from light and moisture to maintain stability. Follow all local regulations for handling radioactive materials, including using appropriate protective equipment and disposing of waste according to radiation safety guidelines.

Iodopol is supplied as an oral solution that is swallowed whole with water. The patient should follow the prescriber’s instructions regarding fasting status, timing of the dose, and any required precautions to minimize radiation exposure to others after administration.

The most serious risks include bone marrow suppression, which can lead to significant reductions in blood cell counts, severe or prolonged hypothyroidism requiring lifelong hormone replacement, radiation‑induced thyroiditis, and, in rare cases, pulmonary fibrosis after high cumulative doses. Patients should be monitored closely for these events.

Iodopol should not be used by pregnant or breastfeeding women, individuals with severe renal impairment without appropriate monitoring, patients who have received recent large doses of other radioactive substances, and anyone with known hypersensitivity to iodine or its formulations. Contraindications must be confirmed by the treating physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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