Product image of Iodovine (Povidone, Iodinated) supplied by GNH India

Iodovine

Active Ingredient:
Povidone, Iodinated
Origin:
EU

Iodovine (Povidone, Iodinated)

Povidone‑iodine, the active ingredient in Iodovine, is an antiseptic presented as a vaginal solution for local application. It provides broad‑spectrum antimicrobial activity and is used to reduce the risk of infection during vaginal examinations and procedures in clinical settings.

GNH India supplies Iodovine as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing reliable sourcing and regulatory support for global healthcare providers.

Manufacturer / TM Owner

Pharmabelle Ltd

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Indications & Clinical Uses

Iodovine, a povidone‑iodine antiseptic, is used for vaginal antisepsis and infection prevention during procedures.

  • Vaginal antisepsis: Reduces microbial load on the vaginal mucosa before examinations.
  • Pre‑procedural preparation: Helps prevent postoperative infections during gynecological surgeries.
  • Obstetric care: Supports hygiene during labor and delivery to lower infection risk.

How It Works

  • Povidone‑iodine releases free iodine when applied to tissue. The elemental iodine penetrates microbial cell walls, oxidizing proteins, nucleic acids and lipids, which disrupts essential cellular functions and leads to rapid cell death. The iodine complex remains bound to the povidone carrier, allowing a sustained release that maintains antimicrobial concentration at the application site.

Side Effects

Iodovine may cause local and systemic reactions, most of which are mild and reversible.

Common Side Effects

  • Local irritation: Burning or stinging sensation at the application site.
  • Discoloration: Temporary brown staining of vaginal tissues or discharge.
  • Mild itching: Pruritus confined to the treated area.
  • Vaginal dryness: Transient reduction in moisture.

Serious or Rare Side Effects

  • Allergic reaction: Hives, swelling, or anaphylaxis requiring immediate medical attention.
  • Thyroid dysfunction: Iodine absorption may alter thyroid hormone levels, especially with prolonged use.
  • Severe tissue damage: Necrosis or ulceration if applied to compromised mucosa.

Precautions & Warnings

Before using Iodovine, consider the following precautions to ensure safe and effective application.

  • Contraindication: Avoid use in individuals with known iodine allergy or hypersensitivity.
  • Pregnancy: Use only if clearly needed; consult a healthcare professional due to limited safety data.
  • Breastfeeding: Caution advised; discuss risks with a clinician.
  • Thyroid disease: Patients with hyper‑ or hypothyroidism should be monitored for iodine‑induced effects.
  • Application area: Do not apply to damaged, inflamed or ulcerated vaginal mucosa.
  • Store at below 25°C: Keep the container tightly closed, protect from light and moisture, and store in a cool, dry place.

Avoid Interactions

Iodovine can interact with certain systemic medications and substances; awareness of these interactions helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Lithium: Iodine may increase lithium levels, risking toxicity.
  • Antithyroid drugs (e.g., propylthiouracil, methimazole): May reduce effectiveness of iodine‑based antiseptics.
  • Radioactive iodine therapy: Topical iodine can interfere with thyroid uptake of radioactive iodine.

Moderate Interactions (Monitor Closely)

  • Thyroid hormone replacement (levothyroxine): Excess iodine may alter hormone requirements.
  • Diuretics (thiazide type): May affect iodine excretion and serum levels.
  • ACE inhibitors: Monitor renal function as iodine load can influence electrolyte balance.

Frequently Asked Questions

Iodovine is a povidone‑iodine based vaginal solution employed to achieve antisepsis of the vaginal mucosa and to help prevent infections during gynecological examinations, surgeries, and obstetric procedures. It is applied locally to reduce microbial colonisation before or after invasive vaginal interventions.

When povidone‑iodine contacts tissue, it releases elemental iodine. The iodine penetrates microbial cell walls and oxidises essential proteins, nucleic acids and lipids, disrupting vital cellular processes and causing rapid cell death. This non‑specific mechanism provides broad‑spectrum activity against bacteria, viruses, fungi and protozoa.

The dose and frequency of Iodovine are determined by the prescribing clinician based on the specific procedure and patient needs. Healthcare professionals select the appropriate volume and application method, and patients should follow the instructions provided by their qualified provider.

Safety data for povidone‑iodine use in pregnancy and lactation are limited. It should only be used when clearly indicated and after a risk‑benefit assessment by a healthcare professional. Women who are pregnant or breastfeeding should discuss potential risks with their clinician before use.

To order Iodovine, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Iodovine delivers povidone‑iodine, a broad‑spectrum antiseptic with a well‑established safety profile, whereas many alternative agents rely on single‑target antibiotics or chlorhexidine. Povidone‑iodine offers rapid microbial kill, low resistance potential, and effectiveness against a wide range of pathogens, making it a versatile choice for vaginal preparation.

Iodovine should be stored at temperatures below 25 °C, in its original container, protected from light and moisture. Keep the product in a cool, dry place and ensure the cap is tightly closed to maintain stability and potency.

Iodovine is applied directly to the vaginal mucosa as a solution. The prescriber determines the volume and method of application, which may involve a syringe, applicator or gauze. The product is used topically and should not be ingested.

Serious risks include allergic reactions such as hives, swelling or anaphylaxis, and thyroid dysfunction due to systemic iodine absorption, especially with prolonged or extensive use. Rarely, severe tissue damage or necrosis can occur if the solution contacts already compromised mucosa.

Iodovine should be avoided by individuals with a known allergy or hypersensitivity to iodine or povidone‑iodine, those with active thyroid disease who are not under medical supervision, and patients with damaged, inflamed or ulcerated vaginal tissue. Pregnant or breastfeeding women should only use it after consulting a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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