Product image of Ioduro (123i) De Sodio Ge Healthcare (Sodium Iodide (123 I)) supplied by GNH India

Ioduro (123i) De Sodio Ge Healthcare

Active Ingredient:
Sodium Iodide (123 I)
Origin:
EU

Ioduro (123i) De Sodio Ge Healthcare (Sodium Iodide (123 I))

Sodium Iodide, the active ingredient in Ioduro (123i) De Sodio Ge Healthcare, is a radioactive diagnostic agent presented as a sterile solution for intravenous use. It is employed in nuclear medicine to image thyroid function and to locate iodine‑avid tissues in patients.
GNH India supplies Ioduro (123i) De Sodio Ge Healthcare as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ge Healthcare Bio-Sciences, S.A.U.

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Indications & Clinical Uses

Ioduro (Sodium Iodide‑123) is used in nuclear medicine procedures that target iodine‑handling tissues.

  • Thyroid imaging: provides high‑resolution scintigraphy for assessment of thyroid function and morphology.
  • Detection of ectopic thyroid tissue: helps locate residual or ectopic thyroid tissue after surgery or in congenital cases.
  • Evaluation of pheochromocytoma: used in specific protocols to image catecholamine‑producing tumors that concentrate iodine.

How It Works

  • Sodium Iodide‑123 is a gamma‑emitting radionuclide that is actively transported into thyroid and other iodine‑avid cells via the sodium‑iodide symporter. Once accumulated, its emitted photons are captured by a gamma camera, producing high‑resolution images that reflect tissue uptake and function without delivering a therapeutic radiation dose.

Side Effects

Common Side Effects

  • Nausea: mild, transient discomfort after injection.
  • Vomiting: occasional, usually self‑limiting.
  • Headache: mild to moderate, often resolves spontaneously.
  • Injection site pain: brief discomfort at the venipuncture site.
  • Transient taste alteration: metallic or iodine taste lasting minutes.
  • Mild flushing: temporary skin redness.

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis): rare but requires immediate medical attention.
  • Thyrotoxicosis: excessive thyroid hormone release in susceptible individuals.
  • Radiation‑induced thyroiditis: inflammation of the thyroid gland.
  • Pulmonary edema: extremely rare, associated with high‑dose exposure.
  • Severe hypotension: sudden drop in blood pressure post‑administration.

Precautions & Warnings

Ioduro (Sodium Iodide‑123) should be used with careful clinical assessment and adherence to radiation safety guidelines.

  • Pregnancy: avoid unless essential, as fetal thyroid uptake may occur.
  • Breastfeeding: contraindicated; iodine can be secreted in breast milk.
  • Thyroid disorders: evaluate baseline thyroid function before administration.
  • Renal impairment: monitor renal function, as clearance may be reduced.
  • Allergy to iodine: contraindicated in patients with known hypersensitivity.
  • Radiation safety: employ appropriate shielding and limit exposure time for staff.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Ioduro (Sodium Iodide‑123) may interact with drugs that affect thyroid iodine handling or imaging quality.

Major Interactions (Avoid)

  • Antithyroid drugs (e.g., methimazole, propylthiouracil): reduce iodine uptake, compromising image quality.
  • Lithium therapy: alters thyroid iodine transport, potentially affecting results.
  • High‑dose iodine supplements: compete for uptake, leading to false‑negative scans.

Moderate Interactions (Monitor Closely)

  • Thyroid hormone replacement: may modify baseline activity, requiring dose adjustment of the radiopharmaceutical.
  • Contrast agents (iodinated): can transiently block iodine uptake; schedule imaging accordingly.
  • Beta‑blockers: may mask symptoms of adverse reactions such as tachycardia.

Frequently Asked Questions

Ioduro (123i) De Sodio contains Sodium Iodide‑123, a radioactive diagnostic agent used in nuclear medicine to produce high‑resolution images of the thyroid gland and other iodine‑avid tissues. It helps clinicians assess thyroid function, locate ectopic thyroid tissue, and evaluate certain neuroendocrine tumors.

Sodium Iodide‑123 is taken up by cells that express the sodium‑iodide symporter, especially thyroid follicular cells. Once inside the cells, the gamma‑emitting iodine‑123 provides a detectable signal for a gamma camera, allowing physicians to visualize the distribution and activity of iodine‑handling tissues without delivering a therapeutic radiation dose.

The specific dose of Ioduro (123i) De Sodio is determined by the prescribing physician based on the diagnostic protocol, patient weight, and clinical indication. Dosage decisions are individualized and should follow the guidelines of the nuclear medicine department and the product’s prescribing information.

Sodium Iodide‑123 is generally avoided in pregnancy unless the diagnostic benefit outweighs the potential risk to the fetus, as the fetal thyroid can accumulate iodine. It is contraindicated during breastfeeding because iodine can be secreted in breast milk, potentially exposing the infant.

To order, submit an enquiry on the product page at gnhindia.com, providing the required quantity and your institutional credentials. GNH India supplies hospitals, pharmacies, and procurement teams worldwide, and will respond with pricing, availability, shipping details (including any cold‑chain requirements), and the necessary import documentation.

Ioduro (Sodium Iodide‑123) offers superior image quality and lower radiation dose compared with Iodine‑131, which is primarily therapeutic. Compared with Technetium‑99m pertechnetate, Sodium Iodide‑123 provides better quantitative assessment of thyroid uptake because it is actively transported via the sodium‑iodide symporter.

Ioduro should be stored at 2‑8 °C in its original sealed container, protected from light, and must not be frozen or shaken. Handling should be performed in a controlled environment with appropriate radiation safety measures to protect personnel.

Ioduro is administered intravenously by a qualified healthcare professional. The injection is typically given as a single dose, after which the patient may be positioned for imaging using a gamma camera at the appropriate time interval dictated by the imaging protocol.

The most serious risks include severe allergic reactions (anaphylaxis), radiation‑induced thyroiditis, and, in rare cases, thyrotoxicosis or pulmonary edema. Patients should be monitored for any signs of hypersensitivity or unexpected thyroid hormone changes following administration.

Ioduro should not be given to patients with known iodine allergy, pregnant or breastfeeding women unless the diagnostic benefit justifies the risk, and individuals with uncontrolled thyroid disorders where iodine uptake could exacerbate the condition. Clinical judgment is essential to determine suitability.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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