Product image of Iohexol Adoh (Iohexol) supplied by GNH India

Iohexol Adoh

Active Ingredient:
Iohexol
Origin:
EU

Iohexol Adoh (Iohexol)

Iohexol, the active ingredient in Iohexol Adoh, is an iodinated contrast agent presented as a sterile solution for intraarterial and intravenous use. It enhances radiographic imaging by increasing X‑ray attenuation in vascular and tissue spaces, facilitating diagnostic procedures.
GNH India supplies Iohexol Adoh as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Adoh B.V.

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Indications & Clinical Uses

Iohexol Adoh is employed in diagnostic radiology procedures that require enhanced vascular or tissue contrast.

  • Angiography: provides clear visualization of blood vessels for diagnostic assessment.
  • Computed tomography (CT) imaging: improves delineation of anatomical structures and lesions.
  • Urography: enhances imaging of the urinary tract for functional and structural evaluation.
  • Arthrography: facilitates detailed joint imaging to assess cartilage and soft‑tissue integrity.
  • Myelography: improves spinal canal visualization for detecting nerve‑root or disc pathology.

How It Works

  • Iohexol contains multiple iodine atoms that confer high radiodensity. After intraarterial or intravenous administration, the iodine atoms absorb X‑rays more effectively than surrounding tissues, increasing attenuation and producing a temporary contrast enhancement in vascular and extracellular spaces, thereby allowing detailed imaging of anatomical structures.

Side Effects

Adverse reactions to Iohexol Adoh may vary in frequency and severity.

Common Side Effects

  • Warmth or flushing sensation during injection.
  • Metallic taste in the mouth.
  • Mild nausea or vomiting.
  • Transient headache or dizziness.
  • Itching or mild skin rash.

Serious or Rare Side Effects

  • Severe allergic reaction or anaphylaxis.
  • Acute kidney injury, especially in patients with pre‑existing renal impairment.
  • Hypotension or cardiovascular collapse.
  • Cardiac arrhythmias.
  • Seizures or neurologic disturbances.
  • Pulmonary edema or respiratory distress.

Precautions & Warnings

Prior to using Iohexol Adoh, clinicians should assess patient‑specific risk factors and follow safe handling practices.

  • Renal function assessment: evaluate kidney function before administration.
  • Allergy history: screen for iodine or contrast media hypersensitivity.
  • Thyroid disease: monitor patients with hyperthyroidism or thyroid dysfunction.
  • Pregnancy: use only when diagnostic benefit outweighs potential fetal risk.
  • Hydration: ensure adequate fluid intake to reduce renal load.
  • Store at ambient temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Iohexol Adoh may interact with other medicines that affect renal function or iodine load.

Major Interactions (Avoid)

  • Metformin: increased risk of lactic acidosis; discontinue before contrast use.
  • Iodine‑containing medications: may raise total iodine exposure.
  • ACE inhibitors: potential for worsening renal impairment.
  • Nephrotoxic antibiotics (e.g., aminoglycosides): heightened risk of kidney injury.

Moderate Interactions (Monitor Closely)

  • Diuretics: may alter fluid balance and affect contrast clearance.
  • Beta‑blockers: can mask contrast‑induced hypertension.
  • Thyroid hormone therapy: monitor thyroid function tests during repeated studies.

Frequently Asked Questions

Iohexol Adoh is a diagnostic radiology contrast medium used to enhance imaging during procedures such as angiography, computed tomography (CT) scans, urography, arthrography, and myelography. By increasing X‑ray attenuation, it helps clinicians obtain clearer images of blood vessels, organs, and soft tissues.

Iohexol contains multiple iodine atoms that absorb X‑rays more effectively than surrounding tissues. When injected intra‑arterially or intravenously, the iodine creates a temporary increase in radiodensity, highlighting vascular and extracellular spaces on X‑ray‑based imaging modalities.

The dose of Iohexol Adoh is individualized and determined by the prescribing physician based on the specific imaging study, patient weight, renal function, and the required level of contrast enhancement. No standard dose is provided here.

Iohexol Adoh is classified as Pregnancy Category B, indicating that animal studies have not shown risk but there are no adequate human studies. It should be used in pregnancy only if the diagnostic benefit outweighs potential risks. Limited data are available for breastfeeding; clinicians should weigh benefits against possible exposure to the infant.

To order Iohexol Adoh, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide, and will request trade or institutional credentials. The sales team will then respond with pricing, availability, shipping details (including any cold‑chain requirements), and import documentation.

Iohexol is a non‑ionic, low‑osmolality iodinated contrast medium, offering a favorable safety profile compared with older high‑osmolality agents. Compared with alternatives such as iopamidol or iopromide, Iohexol provides similar image quality while generally causing fewer adverse reactions, though individual patient tolerance can vary.

Iohexol Adoh should be stored at ambient temperature, typically below 25 °C, in its original sealed container. Protect the product from direct sunlight, excessive heat, and moisture. Do not freeze the solution, and inspect the vial for particulate matter before use.

Iohexol Adoh is administered by a qualified healthcare professional via intra‑arterial or intravenous injection, usually through a peripheral or central venous line. The injection rate and volume are tailored to the imaging protocol and patient characteristics, and the procedure is performed under sterile conditions.

The most serious risks include severe allergic reactions (anaphylaxis), acute kidney injury, hypotension or cardiovascular collapse, and rare neurologic events such as seizures. Patients with pre‑existing renal impairment, known iodine allergy, or uncontrolled thyroid disease require careful assessment before use.

Iohexol Adoh is contraindicated in patients with a documented hypersensitivity to iodinated contrast media or any of its components. Caution is advised for individuals with severe renal insufficiency, uncontrolled hyperthyroidism, or a history of severe allergic reactions. Pregnant women should only receive it when the diagnostic benefit justifies potential risk.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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