Product image of Iohexol Imax (Iohexol) supplied by GNH India

Iohexol Imax

Active Ingredient:
Iohexol
Origin:
EU

Iohexol Imax (Iohexol)

Iohexol, the active ingredient in Iohexol Imax, is an iodinated contrast agent presented as a sterile solution for intra‑arterial, intrathecal, and intravenous administration. It enhances radiographic contrast by increasing X‑ray attenuation, facilitating detailed visualization during diagnostic imaging procedures such as computed tomography (CT), angiography, and urography in adult and pediatric patients.

GNH India supplies Iohexol Imax as a licensed, GDP‑compliant product, providing reliable global distribution to hospitals, imaging centres, and clinics worldwide, with support for regulatory compliance, quality assurance, and timely delivery.

Manufacturer / TM Owner

Imax Diagnostic Imaging Limited

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Indications & Clinical Uses

Iohexol is used as an iodinated radiographic contrast medium to improve X‑ray based imaging.

  • Computed Tomography (CT): Provides enhanced contrast for detailed cross‑sectional imaging.
  • Angiography: Improves vessel delineation for arterial and venous studies.
  • Urography: Highlights urinary tract structures for functional assessment.
  • Myelography (intrathecal): Supplies contrast for spinal canal visualization.

How It Works

  • Iohexol contains a high concentration of iodine atoms that absorb X‑ray photons, thereby increasing the attenuation of the X‑ray beam in the vascular and tissue compartments where it is distributed. This heightened attenuation creates a contrast between enhanced structures and surrounding tissues, allowing clearer radiographic and computed tomography images during diagnostic procedures.

Side Effects

Adverse reactions may occur following administration of iodinated contrast agents.

Common Side Effects

  • Warm sensation or flushing: Transient feeling of heat.
  • Nausea: Mild to moderate upset stomach.
  • Vomiting: Occasional emesis after injection.
  • Headache: Temporary mild headache.
  • Urticaria: Itchy skin rash.
  • Taste alteration: Metallic taste in mouth.

Serious or Rare Side Effects

  • Anaphylactic reaction: Severe allergic response requiring emergency care.
  • Renal toxicity: Acute kidney injury, especially in patients with pre‑existing renal impairment.
  • Seizures: Neurological events in rare cases.
  • Hypotension: Significant drop in blood pressure.
  • Cardiac arrest: Life‑threatening cardiac event.
  • Pulmonary edema: Fluid accumulation in lungs.

Precautions & Warnings

Prior to use, clinicians should evaluate patient risk factors and follow appropriate monitoring.

  • Renal function assessment: Check serum creatinine and eGFR before administration.
  • Allergy screening: Verify history of iodine or contrast media reactions.
  • Thyroid status: Avoid in patients with uncontrolled hyperthyroidism.
  • Hydration: Ensure adequate fluid intake to reduce renal risk.
  • Dose minimization: Use the lowest effective volume for the imaging study.
  • Store at below 25°C: Keep in original packaging, protect from moisture and light.

Avoid Interactions

Iohexol may interact with other medications, influencing safety or efficacy.

Major Interactions (Avoid)

  • Metformin: Risk of lactic acidosis; consider temporary discontinuation.
  • Thyroid hormone therapy: Excess iodine can alter hormone levels.
  • Nephrotoxic agents (e.g., aminoglycosides): Increased risk of renal injury.

Moderate Interactions (Monitor Closely)

  • NSAIDs: May compound renal stress.
  • Diuretics: Potential for volume depletion.
  • ACE inhibitors or ARBs: May affect renal perfusion.
  • Beta‑blockers: May mask tachycardia from contrast reaction.
  • Corticosteroids: May influence immune response.

Frequently Asked Questions

Iohexol Imax is an iodinated radiographic contrast medium used to enhance image quality during diagnostic procedures such as computed tomography (CT), angiography, urography, and intrathecal myelography. By increasing X‑ray attenuation, it allows clinicians to visualize vascular structures, organs, and the urinary tract with greater clarity.

Iohexol contains a high density of iodine atoms, which absorb X‑ray photons more effectively than surrounding tissues. When injected, the iodine‑rich solution circulates through the bloodstream and tissues, creating areas of increased attenuation that appear brighter on X‑ray‑based images, thereby improving the contrast between structures.

The dose of Iohexol Imax is determined by the prescribing physician based on the specific imaging study, patient weight, renal function, and the required level of contrast. Healthcare professionals calculate the appropriate volume and concentration to achieve optimal image quality while minimizing risk.

The safety of Iohexol Imax in pregnancy and lactation has not been definitively established. It should be used only if the diagnostic benefit outweighs potential risks, and the decision should be made by the treating physician in consultation with obstetric or pediatric specialists.

To order Iohexol Imax, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Iohexol Imax is comparable to other non‑ionic, low‑osmolality iodinated contrast media in terms of image enhancement and safety profile. Compared with older high‑osmolality agents, Iohexol typically offers reduced incidence of discomfort and adverse reactions, while providing similar diagnostic efficacy for CT and angiographic studies.

Iohexol Imax should be stored at temperatures below 25 °C, in its original sealed container, protected from light and moisture. Do not freeze the product. Before use, inspect the vial for particulate matter or discoloration and handle with aseptic technique.

Iohexol Imax is supplied as a sterile solution for injection and is administered by a qualified healthcare professional via intra‑arterial, intravenous, or intrathecal routes, depending on the imaging procedure. The injection is typically performed using a power injector or manual bolus under imaging guidance.

The most serious risks include severe allergic reactions such as anaphylaxis, acute kidney injury especially in patients with pre‑existing renal impairment, and rare cardiovascular events like hypotension or cardiac arrest. Immediate medical attention is required if any of these serious reactions occur.

Iohexol Imax should be avoided in patients with a known hypersensitivity to iodinated contrast media, uncontrolled hyperthyroidism, severe renal insufficiency, or in those who have experienced a prior severe reaction to a similar agent. Clinicians must evaluate each patient’s medical history before administration.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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